公开(公告)号：US20220119474A1

公开(公告)日：2022-04-21

申请号：US17431867

申请日：2020-02-19

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Rachel BAR-SHAVIT ,  Chaim GILON ,  Amnon HOFFMAN

IPC: C07K14/705 ,  A61P35/00

Abstract: The present invention provides peptides derived from the cytoplasmic region of protease-activated receptors 4 (PAR4) as well as analogs and cyclic analogs, such as backbone cyclic analogs, of these peptides. Pharmaceutical compositions comprising said peptides, analog, cyclic analogs and well as conjugates thereof are provides as well. The peptides, analogs and conjugates of the present invention and pharmaceutical composition comprising thereof have several uses including treating cancer and inhibiting interactions between PARs and protein comprising PH-domain.

公开(公告)号：US20230331781A1

公开(公告)日：2023-10-19

申请号：US18323210

申请日：2023-05-24

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Rachel BAR-SHAVIT ,  Chaim GILON ,  Amnon HOFFMAN ,  Beatrice UZIELY

IPC: C07K7/64 ,  A61P35/00

CPC classification number: C07K7/64 ,  A61P35/00

Abstract: The present invention provides peptides derived from the cytoplasmic region of protease-activated receptors 4 (PAR4) as well as analogs and cyclic analogs, such as backbone cyclic analogs, of these peptides. Pharmaceutical compositions comprising said peptides, analog, cyclic analogs and well as conjugates thereof are provided as well. The peptides, analogs and conjugates of the present invention and pharmaceutical composition comprising thereof have several uses including treating cancer such as cancer expressing PAR proteins such as cancer expressing ErbB protein and triple negative cancer. and inhibiting interactions between PARs and protein comprising PH-domain.

公开(公告)号：US20180134752A1

公开(公告)日：2018-05-17

申请号：US15682057

申请日：2017-08-21

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Rachel BAR-SHAVIT

IPC: C07K7/08 ,  C07K14/72 ,  C07K14/705 ,  A61K38/08 ,  C07K7/06 ,  A61K38/10 ,  A61K38/17

CPC classification number: C07K7/08 ,  A61K38/08 ,  A61K38/10 ,  A61K38/177 ,  C07K7/06 ,  C07K14/705 ,  C07K14/723

Abstract: The present invention concerns isolated PAR1 cytoplasmic tail (c-tail) peptides and isolated PAR2 cytoplasmic tail (c-tail) peptides, as well as compositions comprising these peptides, uses thereof and methods of treating various diseases, in particular cancer.