公开(公告)号：US4666911A

公开(公告)日：1987-05-19

申请号：US281343

申请日：1981-07-08

申请人： Hajime Fujimura ,  Yasuzo Hiramatu ,  Takahiro Yabuuchi ,  Masakatu Hisaki ,  Katsuo Takikawa ,  Takaji Honna ,  Hidekazu Miyake ,  Makoto Kajitani

发明人： Hajime Fujimura ,  Yasuzo Hiramatu ,  Takahiro Yabuuchi ,  Masakatu Hisaki ,  Katsuo Takikawa ,  Takaji Honna ,  Hidekazu Miyake ,  Makoto Kajitani

IPC分类号： C07D213/74 ,  C07D239/42 ,  C07D277/42 ,  C07D295/215 ,  C07D317/68 ,  A61K31/495 ,  C07D295/10 ,  C07D295/14 ,  C07D295/16

CPC分类号： C07D213/74 ,  C07D239/42 ,  C07D277/42 ,  C07D295/215 ,  C07D317/68

摘要： An analgesic compositon containing as active ingredient an allophanoylpiperazine compound represented by the general formula ##STR1## wherein R.sup.1 represents a lower alkyl group or phenyl group; R.sup.2 and R.sup.3 each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a phenyl group or a substituted phenyl group having as substituent a halogen atom or methyl, trifluoromethyl, hydroxyl, methoxy, methylenedioxy, nitro, or carboxyl group; pyridyl group, pyrimidyl group, thiazolyl group, benzyl group, cinnamyl group, cyclohexyl group, a lower alkyl group, a substituted lower alkyl group having chlorine atom or hydroxyl group as substituent; or a lower alkenyl group.

摘要翻译： 一种止痛组合物，含有作为活性成分的由通式为“IMAGE”表示的脲基甲酰基哌嗪化合物，其中R1表示低级烷基或苯基; R2和R3各自表示氢原子或低级烷基; R4表示苯基或具有卤素原子取代基的取代苯基或甲基，三氟甲基，羟基，甲氧基，亚甲二氧基，硝基或羧基; 吡啶基，嘧啶基，噻唑基，苄基，肉桂基，环己基，低级烷基，具有氯原子或羟基的取代的低级烷基作为取代基; 或低级烯基。