-
1.发明公开公开(公告)号：US20240238479A1
公开(公告)日：2024-07-18
申请号：US18135733
申请日：2023-04-17
发明人： Qingzhi Deng , Zhihong Zhang , Yufei Xiong , Wei Huang , Quan Zhang , Bair Zu
IPC分类号： A61L27/26
CPC分类号： A61L27/26 , A61L2400/06 , A61L2430/34
摘要： The present disclosure provides a collagen and sodium hyaluronate cross-linked composite filler for injection and a preparation method thereof. The collagen and sodium hyaluronate cross-linked composite filler is obtained by a cross-linking reaction of collagen and sodium hyaluronate with a 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) cross-linking system. As the EDC/NHS is used as a cross-linking agent in the present disclosure, the resulting product has no biological toxicity, so that the injury caused by a final product to an injection site and the human body is reduced. Meanwhile, due to intramolecular and intermolecular cross-linking, the degradation rate of the collagen and the sodium hyaluronate is reduced, and the retention time of the two in the body is prolonged. Therefore, the collagen and sodium hyaluronate cross-linked composite filler for injection in the present disclosure can be used in plastic surgery in the medical industry.
-
2.发明公开公开(公告)号：US20230414844A1
公开(公告)日：2023-12-28
申请号：US17899612
申请日：2022-08-31
发明人： Zhihong Zhang , Qingzhi Deng , Yufei Xiong , Wei Huang
CPC分类号： A61L31/145 , A61L31/042 , A61L31/048
摘要： The present disclosure discloses a cross-linked hydrogel microneedle for transdermal drug delivery and a method for preparing the same. The preparation method includes the following steps: mixing a polyvinyl alcohol solution and a hyaluronic acid solution; freeze-thawing the mixed solution in a mold to obtain a gel with no fluidity; and demolding the gel and further performing irradiation cross-linking to obtain the cross-linked hydrogel microneedle. The preparation method described in the present disclosure overcomes the problem of poor stability that exists in the preparation by a freeze-thaw method and the problem of easy introduction of air bubbles that exists in the preparation by an irradiation method, and can increase the yield of the microneedles, which is conducive to mass production. The prepared microneedles can be transported and stored for a long time and have wide application prospects.
-
搜索结果
2 条记录 (耗时 0.015 秒)
