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1.发明申请DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 审中-公开二苯醚衍生物及其用于结合和成像淀粉样物质的用途公开(公告)号：US20110158907A1
公开(公告)日：2011-06-30
申请号：US12595131
申请日：2008-04-18
申请人： Hank F. Kung , Mei-Ping Kung , Wenchao Qu
发明人： Hank F. Kung , Mei-Ping Kung , Wenchao Qu
IPC分类号： A61K51/00 , C07D249/06 , C07F13/00 , A61K31/4192 , A61P25/28
CPC分类号： C07D249/06
摘要： This invention relates to a method of imaging amyloid deposits and to diphenyl-heteroaryl compounds, and methods of making radiolabeled diphenyl-heteroaryl compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及淀粉样蛋白沉积物和二苯基 - 杂芳基化合物的成像方法，以及制备用于成像淀粉样沉积物的放射性标记的二苯基 - 杂芳基化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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2.发明授权Single diastereomers of 4-fluoroglutamine and methods of their preparation and use 有权4-氟谷氨酰胺的单一非对映异构体及其制备和使用方法公开(公告)号：US08747809B2
公开(公告)日：2014-06-10
申请号：US13389521
申请日：2010-08-13
申请人： Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
发明人： Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
IPC分类号： A61K51/00 , C07D209/48
CPC分类号： C07C309/73 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C231/12 , C07C237/06 , C07C271/22
摘要： The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
摘要翻译： 本发明涉及具有至少80％的非对映异构体过量的4-氟谷氨酰胺的单一非对映异构体。 还描述了制备单一非对映体的方法，以及使用放射性标记的4-氟谷氨酰胺的单一非对映异构体作为成像剂的方法。
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3.发明申请SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS OF THEIR PREPARATION AND USE 有权四氟胺的单一反应物及其制备和使用方法公开(公告)号：US20120288444A1
公开(公告)日：2012-11-15
申请号：US13389521
申请日：2010-08-13
申请人： Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
发明人： Hank F. Kung , Craig B. Thompson , Wenchao Qu , Karl Ploessl
IPC分类号： C07C237/06 , C07C231/12 , C07C271/22 , A61K51/04 , C07C309/73
CPC分类号： C07C309/73 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C231/12 , C07C237/06 , C07C271/22
摘要： The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
摘要翻译： 本发明涉及具有至少80％的非对映异构体过量的4-氟谷氨酰胺的单一非对映异构体。 还描述了制备单一非对映体的方法，以及使用放射性标记的4-氟谷氨酰胺的单一非对映异构体作为成像剂的方法。
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