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39 条记录 (耗时 0.036 秒)

    Immortalized mouse fibroblast cell lines deficient in Bax and/or Bak
    3.
    发明授权
    Immortalized mouse fibroblast cell lines deficient in Bax and/or Bak 有权
    在Bax和/或Bak缺乏的永生化小鼠成纤维细胞系

    公开(公告)号：US08389276B2

    公开(公告)日：2013-03-05

    申请号：US10291549

    申请日：2002-11-12

    申请人： Wei-Xing Zong ,  Craig B. Thompson ,  Tullia Lindsten

    发明人： Wei-Xing Zong ,  Craig B. Thompson ,  Tullia Lindsten

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/07 ,  C12N5/09

    CPC分类号： G01N33/5044 ,  C12N5/0652 ,  C12N2510/04 ,  G01N33/5008 ,  G01N33/5011 ,  G01N2510/00

    摘要： The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.

    摘要翻译： 本发明涉及包含永久性细胞系的组合物，所述永生化细胞系缺乏一种或多种选自Bax，Bak及其混合物的内在凋亡途径基因的表达。 本发明还涉及一种不育Bax，Bak及其混合物的永生化小鼠成纤维细胞系的制备方法的产物。 最后，本发明涉及用于鉴定诱导或阻断外源性凋亡途径的化合物或组合物的方法和试剂盒。

    Vertebrate apoptosis gene: compositions and methods
    7.
    发明授权
    Vertebrate apoptosis gene: compositions and methods 失效
    脊椎动物凋亡基因：组成和方法

    公开(公告)号：US06303331B1

    公开(公告)日：2001-10-16

    申请号：US08461511

    申请日：1995-06-05

    申请人： Craig B. Thompson ,  Lawrence H. Boise ,  Gabriel Nuñez

    发明人： Craig B. Thompson ,  Lawrence H. Boise ,  Gabriel Nuñez

    IPC分类号： C12N1563

    CPC分类号： C07K14/4747 ,  C07K14/465

    摘要： The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

    摘要翻译： 本发明一般涉及获得和使用影响程序性脊椎动物细胞死亡的BCL-2以外的多肽的组合物和方法。 本发明还涉及编码那些多肽的多核苷酸，携带那些序列的重组载体，包含序列或载体的重组宿主细胞和重组多肽。 本发明还提供了在分析设计用于选择和改善能够改变程序性细胞死亡的物质用于诊断，药物设计和治疗应用的测定中使用分离的重组多肽的方法。

    Taco shell manufacturing equipment using a low pressure steam chamber
    8.
    发明授权
    Taco shell manufacturing equipment using a low pressure steam chamber 失效
    塔克贝壳制造设备采用低压蒸汽室

    公开(公告)号：US4197793A

    公开(公告)日：1980-04-15

    申请号：US822737

    申请日：1977-08-08

    申请人： Sheldon H. Hanson ,  Craig B. Thompson ,  James E. Olson

    发明人： Sheldon H. Hanson ,  Craig B. Thompson ,  James E. Olson

    IPC分类号： A21B5/08 ,  A47J37/12

    CPC分类号： A47J37/1214 ,  A21B5/08

    摘要： Taco shell manufacturing equipment that comprises in combination with suitable means to form and bake disk tortillas, certain means to equilibrate moisture throughout such baked tortillas in a relatively short tempering time of the general order of a few minutes as they are passed in successive longitudinally-spaced groups of substantially transversely aligned disks continuously through an elongated lateral steam chamber upon traveling lateral open web belting means as received from baking means and while being subjected in this chamber to relatively low pressure steam until discharged by this belting means through an exit end opening of the steam chamber as tempered tortillas. Driven lateral transfer means receive the tempered tortillas in the longitudinally-spaced transverse groups from the exit end of the steam chamber and transports them laterally forward to the entrance end of tortillas folding and frying apparatus. The equipment includes means for transporting the tortillas in lap-folded form through a hot fat bath in the frying apparatus, and means to deliver the fried tortillas as lap-folded taco shells from the frying apparatus to suitable packing means for ultimate marketing.

    摘要翻译： 塔科壳制造设备包括与合适的手段相结合以形成和烘烤圆盘玉米粉圆饼，某些方法是在相当短的回火时间内平衡这些烘烤的玉米粉圆饼的水分，通常在几分钟的时间内连续地纵向间隔 一组基本上横向对准的盘连续地穿过细长的侧向蒸汽室，当从烘烤装置接收到的行进的侧开式卷筒纸捆绑装置时，并且在该室中经受相对低压的蒸汽，直到由该捆扎装置通过出口端开口排出 蒸汽室作为回火玉米饼。 驱动的侧向转移装置从蒸汽室的出口端沿纵向间隔开的横向组中接收回火的玉米粉圆饼，并将它们横向前进到玉米饼圆饼折叠和煎炸装置的入口端。 该设备包括用于通过煎炸设备中的热脂肪浴将折叠形式的玉米粉圆饼运送的装置，以及将油炸玉米饼作为卷边折叠的玉米饼壳从煎炸设备输送到用于最终营销的合适的包装装置的装置。

    Compositions and methods for treating cancer
    9.
    发明授权
    Compositions and methods for treating cancer 有权
    用于治疗癌症的组合物和方法

    公开(公告)号：US09060993B2

    公开(公告)日：2015-06-23

    申请号：US10556220

    申请日：2004-05-07

    申请人： Craig B. Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

    发明人： Craig B. Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

    IPC分类号： A61K31/34 ,  A61K51/04

    CPC分类号： A61K31/34 ,  A61K51/0491

    摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

    摘要翻译： 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸酯转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的步骤，所述方法包括以下步骤：将癌症识别为具有高比例的需氧糖酵解，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。