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公开(公告)号:US06225052B1
公开(公告)日:2001-05-01
申请号:US08975894
申请日:1997-11-21
申请人: Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Schuster , Bruce A. Armitage , Danith Ly
发明人: Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Schuster , Bruce A. Armitage , Danith Ly
IPC分类号: C12Q168
CPC分类号: C07H21/00 , C07K14/003 , C12Q1/6818 , Y10S435/81
摘要: New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.
摘要翻译: 提供了新的电子转移部分标记的核酸类似物探针,其可用于测定样品中核酸的方法。 可以在化学合成途径中使用新型单体亚单位制备新的探针。 核酸可以通过将探针分子与核酸结合并在形成的复合物内诱导电子转移来确定。 电子转移的发生被确定为核酸的量度。
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公开(公告)号:US6117973A
公开(公告)日:2000-09-12
申请号:US805411
申请日:1997-02-24
申请人: Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Shuster , Bruce A. Armitage
发明人: Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Shuster , Bruce A. Armitage
CPC分类号: C07H21/00 , C07K14/003 , C12Q1/6818 , Y10S435/81
摘要: New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.
摘要翻译: 提供了新的电子转移部分标记的核酸类似物探针,其可用于测定样品中核酸的方法。 可以在化学合成途径中使用新型单体亚单位制备新的探针。 核酸可以通过将探针分子与核酸结合并在形成的复合物内诱导电子转移来确定。 电子转移的发生被确定为核酸的量度。
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