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    TRPV1 + SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES
    1.
    发明申请
    TRPV1 + SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES 审中-公开
    TRPV1 +感觉神经元控制糖尿病患者的细胞应力和血小板渗透

    公开(公告)号：US20090221511A1

    公开(公告)日：2009-09-03

    申请号：US12394261

    申请日：2009-02-27

    申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K38/08 ,  A61K31/165 ,  A61P3/10

    CPC分类号： A61K38/046 ,  Y10S514/866

    摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

    摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

    STIMULATION OF TRPV1+ SENSORY NEURONS TO CONTROL BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES
    2.
    发明申请
    STIMULATION OF TRPV1+ SENSORY NEURONS TO CONTROL BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES 审中-公开
    刺激TRPV1 +感觉神经元以控制糖尿病中的细胞应力和血小板渗透

    公开(公告)号：US20090312255A1

    公开(公告)日：2009-12-17

    申请号：US12478898

    申请日：2009-06-05

    申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K31/165 ,  A61P3/10 ,  A61K38/17

    CPC分类号： A61K38/046 ,  A61K31/165

    摘要： The present invention provides a method of altering the function of TRPV1+ sensory afferent neurons in the pancreas as a way of treating, managing, alleviating, etc., the symptoms and/or underlying causes of diabetes or abnormal glucose metabolism by increasing the release of neuropeptides, such as substance P (sP) or other tachykinin peptide, in the pancreas. This may be achieved by injecting a TRPV1 agonist, such as a capsaicinoid compound or capsaicin analog, or a neuropeptide, such as sP or other tachykinin peptide, directly into the pancreas, or alternatively, by stimulating one or more intercostal and/or subcostal nerves of spinal nerves derived from one or more thoracic segments T8 through T12 by chemical, electrical, surgical, mechanical, etc., methods.

    摘要翻译： 本发明提供了一种通过增加神经肽的释放来改变胰腺中TRPV1 +感觉传入神经元的功能的方法，作为治疗，控制，缓解等症状和/或糖尿病异常或糖代谢异常的原因的方法 ，例如胰岛中的物质P（sP）或其他速激肽肽。 这可以通过将TRPV1激动剂如辣椒素化合物或辣椒素类似物或神经肽如sP或其它速激肽肽直接注射到胰腺中，或者通过刺激一种或多种肋间和/或肋下神经来实现 通过化学，电气，手术，机械等方法从一个或多个胸段T8至T12衍生的脊神经。

    METHOD FOR REVERSING RECENT-ONSET TYPE 1 DIABETES (T1D) BY ADMINISTERING SUBSTANCE P (sP)
    3.
    发明申请
    METHOD FOR REVERSING RECENT-ONSET TYPE 1 DIABETES (T1D) BY ADMINISTERING SUBSTANCE P (sP) 审中-公开
    通过管理物质P（sP）反转最近一型糖尿病（T1D）的方法

    公开(公告)号：US20150099697A1

    公开(公告)日：2015-04-09

    申请号：US14244990

    申请日：2014-04-04

    申请人： Hans-Michael DOSCH

    发明人： Hans-Michael DOSCH

    IPC分类号： A61K38/08 ,  C12Q1/68 ,  A61K9/00

    CPC分类号： C12Q1/6883 ,  A61K9/0019 ,  A61K38/046 ,  A61K38/08 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： Described herein is a treatment comprising the following step: (a) injecting a therapeutically effective amount of a pharmaceutical composition into the celiac artery of an individual, wherein the pharmaceutical composition reverses recent onset Type 1 Diabetes (T1D). Also described is a method for identifying an individual who will be responsive to this treatment. In addition there is described a device containing the pharmaceutical composition for injecting the pharmaceutical composition into the celiac artery.

    摘要翻译： 本文描述的治疗包括以下步骤：（a）将治疗有效量的药物组合物注射到个体的腹腔动脉中，其中药物组合物逆转最近发病的1型糖尿病（T1D）。 还描述了一种用于识别对这种治疗有反应的个体的方法。 此外，还描述了含有用于将药物组合物注入腹腔动脉的药物组合物的装置。