公开(公告)号：US09512087B2

公开(公告)日：2016-12-06

申请号：US13994323

申请日：2012-04-04

申请人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Subhash Prataprao Chavan ,  Mohan Anand Chandavarkar ,  Ramkrishnan Ramachaandran Iyer ,  Amit Chandrakant Tawte ,  Deepali Damodar Rao

发明人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Subhash Prataprao Chavan ,  Mohan Anand Chandavarkar ,  Ramkrishnan Ramachaandran Iyer ,  Amit Chandrakant Tawte ,  Deepali Damodar Rao

IPC分类号： C07D249/08 ,  C07D249/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07D249/08 ,  C07D249/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed herein are novel antifungal compounds of Formula 1, containing fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones and pharmaceutically acceptable salts thereof, methods for preparing these compounds and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections.

公开(公告)号：US20130303579A1

公开(公告)日：2013-11-14

申请号：US13994323

申请日：2012-04-04

申请人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Subhash Prataprao Chavan ,  Mohan Anand Chandavarkar ,  Ramkrishnan Ramachaandran Iyer ,  Amit Chandrakant Tawte ,  Deepali Damodar Rao

发明人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Subhash Prataprao Chavan ,  Mohan Anand Chandavarkar ,  Ramkrishnan Ramachaandran Iyer ,  Amit Chandrakant Tawte ,  Deepali Damodar Rao

IPC分类号： C07D249/08 ,  C07D403/12 ,  C07D409/12

CPC分类号： C07D249/08 ,  C07D249/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed herein are novel antifungal compounds of Formula 1, containing fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones and pharmaceutically acceptable salts thereof, methods for preparing these compounds and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections.

摘要翻译： 本文公开了新颖的式1的抗真菌化合物，其含有与其它部分（包括芳基酮和查尔酮及其药学上可接受的盐）偶联的氟康唑药效团部分，制备这些化合物的方法和含有这些用于预防和治疗真菌感染的新化合物的药物制剂。

公开(公告)号：US08236840B2

公开(公告)日：2012-08-07

申请号：US13058358

申请日：2009-10-01

申请人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Suleman Riyajsaheb Maujan ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

发明人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Suleman Riyajsaheb Maujan ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

IPC分类号： A61K31/41 ,  A61K31/4196 ,  A61P31/10 ,  C07D409/12

CPC分类号： C07D409/12

摘要： The present invention discloses novel compounds of the Formula (1), containing thiophene moieties and pharmaceutically acceptable salts thereof, methods for preparing these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these novel compounds.

摘要翻译： 本发明公开了含有噻吩部分及其药学上可接受的盐的式（1）的新化合物，制备这些化合物的方法，这些化合物在预防和治疗真菌感染中的用途，以及含有这些新化合物的药物制剂。

公开(公告)号：US20110144171A1

公开(公告)日：2011-06-16

申请号：US13058358

申请日：2009-10-01

申请人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Suleman Ruyajsaheb Maujan ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

发明人： Hanumant Bapurao Borate ,  Sangmeshwer Prabhakar Sawargave ,  Suleman Ruyajsaheb Maujan ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

IPC分类号： A61K31/4196 ,  C07D409/12 ,  A61P31/10

CPC分类号： C07D409/12

摘要： The present invention discloses novel compounds of the Formula (1), containing thiophene moieties and pharmaceutically acceptable salts thereof, methods for preparing these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these novel compounds.

摘要翻译： 本发明公开了含有噻吩部分及其药学上可接受的盐的式（1）的新化合物，制备这些化合物的方法，这些化合物在预防和治疗真菌感染中的用途，以及含有这些新化合物的药物制剂。

公开(公告)号：US08129369B2

公开(公告)日：2012-03-06

申请号：US13121730

申请日：2009-10-16

申请人： Hanumant Bapurao Borate ,  Suleman Riyasaheb Maujan ,  Sangmeshwer Prabhakar Sawargave ,  Ramesh Ganesh Kelkar ,  Radhika Dilip Wakharkar ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

发明人： Hanumant Bapurao Borate ,  Suleman Riyasaheb Maujan ,  Sangmeshwer Prabhakar Sawargave ,  Ramesh Ganesh Kelkar ,  Radhika Dilip Wakharkar ,  Mohan Anand Chandavarkar ,  Sharangi Ravinda Vaiude ,  Vinay Anant Joshi

IPC分类号： C07D413/06 ,  C07D417/06 ,  A61K31/423 ,  A61K31/536

CPC分类号： C07D417/06 ,  C07D413/06

摘要： The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal activity, method for preparing these compounds and the use of these compounds as antifungal agents in prevention and treatment of fungal infections, and pharmaceutical preparations containing these novel compounds.

摘要翻译： 本发明公开了具有抗真菌活性的苯并噻嗪酮，苯并恶嗪酮或苯并恶唑啉酮部分的新型式（1）化合物，其制备方法以及这些化合物作为抗真菌剂在预防和治疗真菌感染中的用途，以及含有 这些新化合物。