公开(公告)号：US20080118929A1

公开(公告)日：2008-05-22

申请号：US11883133

申请日：2006-01-24

申请人： Harald Tammen ,  Rudiger Hess ,  Karl Schorn ,  Rudolf Reiter ,  Susanne Neitz ,  Norbert Lamping

发明人： Harald Tammen ,  Rudiger Hess ,  Karl Schorn ,  Rudolf Reiter ,  Susanne Neitz ,  Norbert Lamping

IPC分类号： G01N33/574 ,  C07K14/00 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12Q1/68

CPC分类号： G01N33/57419

摘要： Many disorders, especially neoplastic disorders such as cancer and polyps, are the result of hyperproliferative cells or of cells with differentiation disorders. For these types of disorders early detection is of pivotal importance and reliable and early biomarkers for common types of cancers such as colorectal cancer are still not available. Thus, there is a need for new markers and for methods for identifying such new markers. The invention provides peptides and proteins and derivatives thereof originating from transcription intermediary factor-1 beta (TIF1-beta) suitable as markers and therapeutics for disorders such as cancer, preferably colorectal cancerous or related disorders such as polyps.

摘要翻译： 许多疾病，特别是肿瘤性疾病如癌症和息肉，是过度增殖细胞或具有分化障碍的细胞的结果。 对于这些类型的疾病，早期检测是至关重要的，并且常见类型的癌症如结肠直肠癌的可靠和早期生物标志物仍然不可用。 因此，需要新的标记和用于鉴定这种新标记的方法。 本发明提供源自转录中介因子-1β（TIF1-β）的肽和蛋白质及其衍生物，其适用于诸如癌症，优选结肠直肠癌或相关疾病如息肉的疾病的标记物和治疗剂。