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14 条记录 (耗时 0.015 秒)

    Triazene compounds for the treatment of cancer
    1.
    发明授权
    Triazene compounds for the treatment of cancer 有权
    用于治疗癌症的三氮烯化合物

    公开(公告)号：US08034797B2

    公开(公告)日：2011-10-11

    申请号：US12296475

    申请日：2008-07-03

    申请人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    发明人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    IPC分类号： A61K31/655

    CPC分类号： C07C245/24 ,  C07C309/15 ,  C07D233/64

    摘要： The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

    摘要翻译： 本发明涉及新的三氮烯化合物，其制备方法，包含它们的药物组合物及其在治疗人类癌症疾病中的用途。 与已知的三氮烯化合物相比，新的三氮烯化合物通过改善活性而同时具有降低的毒性，也就是说副作用较少。

    Novel Triazene Compounds For The Treatment Of Cancer
    3.
    发明申请
    Novel Triazene Compounds For The Treatment Of Cancer 有权
    新型三氮烯化合物治疗癌症

    公开(公告)号：US20100234327A1

    公开(公告)日：2010-09-16

    申请号：US12296475

    申请日：2008-07-03

    申请人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    发明人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    IPC分类号： A61K31/655 ,  C07C245/06 ,  A61P35/00

    CPC分类号： C07C245/24 ,  C07C309/15 ,  C07D233/64

    摘要： The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

    摘要翻译： 本发明涉及新的三氮烯化合物，其制备方法，包含它们的药物组合物及其在治疗人类癌症疾病中的用途。 与已知的三氮烯化合物相比，新的三氮烯化合物通过改善活性而同时具有降低的毒性，也就是说副作用较少。

    Automatic-assembly bridge, ramp and the like
    6.
    发明授权
    Automatic-assembly bridge, ramp and the like 失效
    自动装配桥，坡道等

    公开(公告)号：US4972539A

    公开(公告)日：1990-11-27

    申请号：US385017

    申请日：1989-07-25

    申请人： Rudolf Reiter

    发明人： Rudolf Reiter

    IPC分类号： E01D15/127

    CPC分类号： E01D15/127

    摘要： The automatic-assembly bridge, ramp and the like comprises a base segment which has, on one face, two sets of wheels provided with positioning means for disengaging from the ground when the bridge, ramp and the like is installed, as well as an articulation for releasably coupling to a tractor. A second segment is articulated at one end of the base segment and is constituted by a first track and a second track which can be arranged mutually side by side and can be rotated independently from one another so as to be arranged in a transport position, wherein the tracks of the second segment are superimposed on the base segment, and in an installation position, wherein the tracks are arranged substantially along the extension of the base segment. One of the tracks acts as ballast during the rotation of the other track.

    Pharmaceutical Compositions for the Treatment of Capillary Arteriopathy
    7.
    发明申请
    Pharmaceutical Compositions for the Treatment of Capillary Arteriopathy 有权
    用于治疗毛细血管病变的药物组合物

    公开(公告)号：US20140045879A1

    公开(公告)日：2014-02-13

    申请号：US13354832

    申请日：2012-01-20

    申请人： Rudolf Reiter ,  Johannes Tack ,  Reinhard Horowski

    发明人： Rudolf Reiter ,  Johannes Tack ,  Reinhard Horowski

    IPC分类号： C07D471/06

    CPC分类号： C07D471/06 ,  A61K31/00 ,  A61K31/48

    摘要： The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomeruloscleroses as well as secondary Raynaud's syndrome.

    摘要翻译： 本发明涉及麦角衍生物或麦角蛋白，特别是利鲁司特和替麦格德用于预防和治疗缩窄性毛细血管病变的用途。 狭窄性毛细血管动脉病是指肺动脉高压，内源诱导或外源性诱导的肾小球硬化以及继发性雷诺综合征的疾病。

    Novel Triazene Compounds For The Treatment Of Cancer
    8.
    发明申请
    Novel Triazene Compounds For The Treatment Of Cancer 失效
    新型三氮烯化合物治疗癌症

    公开(公告)号：US20120028927A1

    公开(公告)日：2012-02-02

    申请号：US13205831

    申请日：2011-08-09

    申请人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    发明人： Rudolf Reiter ,  Jochen Kalbe ,  Heinz Forster

    IPC分类号： A61K31/655 ,  C07C229/44 ,  A61P35/00 ,  C07C245/24

    CPC分类号： C07C245/24 ,  C07C309/15 ,  C07D233/64

    摘要： The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

    摘要翻译： 本发明涉及新的三氮烯化合物，其制备方法，包含它们的药物组合物及其在治疗人类癌症疾病中的用途。 与已知的三氮烯化合物相比，新的三氮烯化合物通过改善活性而同时具有降低的毒性，也就是说副作用较少。

    Tif1-Beta Peptides and Nucleic Acids for Diagnosis and Therapy of Cancer and Colorectal Cancerous Disorders
    9.
    发明申请
    Tif1-Beta Peptides and Nucleic Acids for Diagnosis and Therapy of Cancer and Colorectal Cancerous Disorders 审中-公开
    Tif1-β肽和核酸用于癌症和结肠直肠癌的诊断和治疗

    公开(公告)号：US20080118929A1

    公开(公告)日：2008-05-22

    申请号：US11883133

    申请日：2006-01-24

    申请人： Harald Tammen ,  Rudiger Hess ,  Karl Schorn ,  Rudolf Reiter ,  Susanne Neitz ,  Norbert Lamping

    发明人： Harald Tammen ,  Rudiger Hess ,  Karl Schorn ,  Rudolf Reiter ,  Susanne Neitz ,  Norbert Lamping

    IPC分类号： G01N33/574 ,  C07K14/00 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12Q1/68

    CPC分类号： G01N33/57419

    摘要： Many disorders, especially neoplastic disorders such as cancer and polyps, are the result of hyperproliferative cells or of cells with differentiation disorders. For these types of disorders early detection is of pivotal importance and reliable and early biomarkers for common types of cancers such as colorectal cancer are still not available. Thus, there is a need for new markers and for methods for identifying such new markers. The invention provides peptides and proteins and derivatives thereof originating from transcription intermediary factor-1 beta (TIF1-beta) suitable as markers and therapeutics for disorders such as cancer, preferably colorectal cancerous or related disorders such as polyps.

    摘要翻译： 许多疾病，特别是肿瘤性疾病如癌症和息肉，是过度增殖细胞或具有分化障碍的细胞的结果。 对于这些类型的疾病，早期检测是至关重要的，并且常见类型的癌症如结肠直肠癌的可靠和早期生物标志物仍然不可用。 因此，需要新的标记和用于鉴定这种新标记的方法。 本发明提供源自转录中介因子-1β（TIF1-β）的肽和蛋白质及其衍生物，其适用于诸如癌症，优选结肠直肠癌或相关疾病如息肉的疾病的标记物和治疗剂。