公开(公告)号：US20050147624A1

公开(公告)日：2005-07-07

申请号：US10505276

申请日：2003-02-24

申请人： Harold Jennings ,  Malgorzata Mieszala ,  Grigorij Kogan ,  Wei Zou ,  James Richards ,  Andrew Cox

发明人： Harold Jennings ,  Malgorzata Mieszala ,  Grigorij Kogan ,  Wei Zou ,  James Richards ,  Andrew Cox

IPC分类号： A61K39/02 ,  A61K47/48 ,  C07K14/195

CPC分类号： A61K47/646

摘要： This invention relates to lipopolysaccharide-protein conjugate vaccines with appropriate presentation of conserved inner core oligosaccharide epitopes having improved immunogenic properties. These are based upon antigenic, detoxified bacterial lipopolysaccharides which optimally present an inner core oligosaccharide epitope following removal of at least a glycosidic phosphate of the lipid A region. These partially or completely dephosphorylated antigenic, detoxified bacterial lipopolysaccharides are linkable to an immunologically acceptable carrier and can be used in polyvalent or multivalent vaccines.

摘要翻译： 本发明涉及具有改善的免疫原性的保守的内核寡糖表位的适当呈递的脂多糖 - 蛋白质结合疫苗。 这些是基于抗原性，解毒的细菌脂多糖，其在去除脂质A区域的至少糖苷磷酸酯之后最佳地呈现内核寡糖表位。 这些部分或完全去磷酸化的抗原性，解毒的细菌脂多糖可与免疫学上可接受的载体连接，可用于多价或多价疫苗。