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公开(公告)号：US20090004213A1
公开(公告)日：2009-01-01
申请号：US12055151
申请日：2008-03-25
CPC分类号： A61K39/0011 , A61K31/404 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55561
摘要： The present invention relates to methods of treating cancer in a mammal comprising administering to the mammal a combination therapy comprising a vaccine and a multi-kinase inhibitor, wherein the vaccine comprises an isolated tumor associated peptide having the ability to bind to a molecule of the human major histocompatibility complex (MHC) class-I or class-II. Preferably the multi-kinase inhibitor is sunitinib malate and/or sorafenib tosylate or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及在哺乳动物中治疗癌症的方法，包括向哺乳动物施用包含疫苗和多激酶抑制剂的组合疗法，其中所述疫苗包含具有结合人类分子的能力的分离的肿瘤相关肽 主要组织相容性复合体（MHC）I类或II类。 优选地，多激酶抑制剂是苹果酸舒尼替尼和/或甲苯磺酸索拉菲尼或其药学上可接受的盐。
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公开(公告)号：US08669230B2
公开(公告)日：2014-03-11
申请号：US12915473
申请日：2010-10-29
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： C07K7/00
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells which can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的新型肽序列及其变体。
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3.发明授权Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers 有权用于治疗胶质母细胞瘤（GBM）和其他癌症的肿瘤相关肽和相关抗癌疫苗的组成公开(公告)号：US08318677B2
公开(公告)日：2012-11-27
申请号：US12571602
申请日：2009-10-01
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.
摘要翻译： 本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。 本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 特别地，本发明的肽的组合物可用于引发针对胶质瘤的抗肿瘤免疫应答的疫苗组合物中。
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公开(公告)号：US08080634B2
公开(公告)日：2011-12-20
申请号：US12180045
申请日：2008-07-25
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： C07K5/00
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells which can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的新型肽序列及其变体。
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5.发明授权公开(公告)号：US07994276B2
公开(公告)日：2011-08-09
申请号：US12180113
申请日：2008-07-25
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Trautwein , Peter Lewandrowski
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Trautwein , Peter Lewandrowski
CPC分类号： A61K39/0011 , A61K38/193 , A61K45/06 , A61K2039/5158 , A61K2039/53 , A61K2039/572 , C07K14/4748 , A61K2300/00
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against colorectal cancer.
摘要翻译： 本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。 本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 特别地，本发明的肽的组合物可用于引发针对结肠直肠癌的抗肿瘤免疫应答的疫苗组合物中。
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公开(公告)号：US20110117117A1
公开(公告)日：2011-05-19
申请号：US12915473
申请日：2010-10-29
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： A61K39/00 , C07K14/47 , C07K7/08 , C07K7/06 , C07K19/00 , C07H21/04 , C07H21/02 , A61K35/26 , A61P35/00 , C12N15/63 , C12N5/10 , C12P21/02 , C12N5/0783
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumour cells which can be used in vaccine compositions for eliciting anti-tumour immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的新型肽序列及其变体。
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公开(公告)号：US20090148400A1
公开(公告)日：2009-06-11
申请号：US12180113
申请日：2008-07-25
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： A61K39/00 , A61K38/08 , A61K38/10 , A61K38/16 , A61P35/00 , A61K38/17 , A61K39/106 , A61K38/19
CPC分类号： A61K39/0011 , A61K38/193 , A61K45/06 , A61K2039/5158 , A61K2039/53 , A61K2039/572 , C07K14/4748 , A61K2300/00
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumour immune responses against colorectal cancer.
摘要翻译： 本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。 本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 特别地，本发明的肽的组合物可用于引发针对结肠直肠癌的抗肿瘤免疫应答的疫苗组合物中。
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8.发明申请TUMOUR-ASSOCIATED PEPTIDES BINDING TO HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I OR II MOLECULES AND RELATED ANTI-CANCER VACCINE 审中-公开肿瘤相关肽与人类白细胞抗原（HLA）I类或II类分子和相关抗癌药物结合公开(公告)号：US20090274714A1
公开(公告)日：2009-11-05
申请号：US12065725
申请日：2006-09-05
IPC分类号： A61K39/00 , C07K7/08 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/10 , A61K31/711 , C12P21/02 , C12N5/06 , C07K14/725 , A61K35/26 , A61P37/02 , C07K7/06 , C07H21/02 , A61K38/08
CPC分类号： C07K14/4748
摘要： The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class II molecules of human tumour cell lines, which can be used in vaccine compositions for eliciting anti-tumour immune responses.
摘要翻译： 本发明涉及免疫治疗方法，以及用于免疫治疗方法的分子和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的单独或与其它肿瘤相关肽组合的肿瘤相关T辅助细胞肽表位。 特别地，本发明涉及衍生自人类肿瘤细胞系的HLA II类分子的两种新型肽序列，其可用于引发抗肿瘤免疫应答的疫苗组合物。
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9.发明授权Immunotherapeutic peptides against neuronal and brain tumors and related methods and compositions 有权针对神经元和脑肿瘤的免疫治疗肽及相关方法和组合物公开(公告)号：US09175040B2
公开(公告)日：2015-11-03
申请号：US12180170
申请日：2008-07-25
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
CPC分类号： A61K35/17 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C12N5/0638
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 11 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的11种新型肽序列及其衍生自人类肿瘤细胞的HLA I类和II类分子的变体。
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10.发明授权公开(公告)号：US08119139B2
公开(公告)日：2012-02-21
申请号：US12571776
申请日：2009-10-01
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可以用于引发抗肿瘤免疫应答的疫苗组合物中的来自人类肿瘤细胞的HLA I类和II类分子的30个肽序列及其变体。
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