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    Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation
    3.
    发明授权
    Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation 失效
    检测固体癌细胞和组织不典型的方法以及用于骨髓移植和外周血干细胞移植的组织检测方法

    公开(公告)号：US06225051B1

    公开(公告)日：2001-05-01

    申请号：US08973967

    申请日：1998-06-26

    申请人： Haruo Sugiyama ,  Kazushi Inoue

    发明人： Haruo Sugiyama ,  Kazushi Inoue

    IPC分类号： C12Q168

    CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407

    摘要： The invention provides a method of detecting solid cancer cells which comprises determining the level of expression of WT1 gene in a test tissue, a method of detecting the atypia of a tissue which comprises determining the level of expression of WT1 gene in the tissue, and a method of testing a graft material tissue for bone marrow or peripheral blood stem cell transplantation which comprises determining the level of expression of WT1 gene in a CD34− cell fraction of the tissue to detect leukemic cells and solid cancer cells in the tissue.

    摘要翻译： 本发明提供一种检测固体癌细胞的方法，其包括测定测试组织中WT1基因的表达水平，检测组织非典型性的方法，其包括测定组织中WT1基因的表达水平，以及 测试用于骨髓或外周血干细胞移植的移植材料组织的方法，其包括确定组织的CD34-细胞级分中WT1基因的表达水平以检测组织中的白血病细胞和固体癌细胞。

    Sewing data modifying apparatus
    4.
    发明授权
    Sewing data modifying apparatus 失效
    缝制数据修改装置

    公开(公告)号：US5537945A

    公开(公告)日：1996-07-23

    申请号：US380515

    申请日：1995-01-30

    申请人： Yoshihide Sugihara ,  Kazushi Inoue ,  Takashi Kondo ,  Jun Gamano ,  Yoshihiro Hara

    发明人： Yoshihide Sugihara ,  Kazushi Inoue ,  Takashi Kondo ,  Jun Gamano ,  Yoshihiro Hara

    IPC分类号： D05B19/16 ,  D05B19/02 ,  D05B21/00 ,  D05B39/00

    CPC分类号： D05B19/02

    摘要： An apparatus for modifying sewing data to control a sewing machine including (a) a stitch-forming device for forming stitches on at least one work sheet, (b) a work-holding device for holding the work sheet, and (c) a displacing device for displacing at least one of the stitch-forming device and the work-holding device, relative to each other, according to the sewing data, the sewing machine having a prescribed coordinate system, the apparatus including a plurality of detectable objects located at a plurality of fixed positions spaced apart from each other on the work-holding device, respectively; a position detector which detects an actual position of each of the detectable objects in the prescribed coordinate system of the sewing machine; and a data modifying device for modifying the sewing data based on a difference of the detected actual position of the each of the detectable objects from a corresponding one of respective reference positions of the detectable objects in the prescribed coordinate system of the sewing machine.

    摘要翻译： 一种用于修改缝制数据以控制缝纫机的装置，包括：（a）用于在至少一个工作片上形成针迹的线圈形成装置，（b）用于保持工作片的工件保持装置，以及（c） 缝纫机具有规定的坐标系，根据缝制数据相对于彼此移动至少一个针织成形装置和工件保持装置的装置，该装置包括多个可检测物体，位于 分别在工作保持装置上彼此间隔开的多个固定位置; 位置检测器，其检测缝纫机的规定坐标系中的每个可检测物体的实际位置; 以及数据修改装置，用于基于所检测到的每个可检测物体的实际位置与缝纫机的规定坐标系中可检测物体的相应参考位置中的相应一个的差异来修改缝制数据。

    Programmable electronic sewing machine
    5.
    发明授权
    Programmable electronic sewing machine 失效
    可编程电子缝纫机

    公开(公告)号：US6024037A

    公开(公告)日：2000-02-15

    申请号：US84214

    申请日：1998-05-26

    申请人： Shinji Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    发明人： Shinji Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    IPC分类号： D05B19/08 ,  D05C5/06

    CPC分类号： D05B19/085

    摘要： A programmable electronic sewing machine includes input means for supplying input data when operated by a user, and sewing program composing means for composing a sewing program for the sewing machine on the basis of the input data supplied from the input means. The sewing program composing means composes the same sewing program on the basis of the input data supplied from the input means when the input means is operated in two or more different operating procedures.

    摘要翻译： 可编程电子缝纫机包括用于在用户操作时提供输入数据的输入装置和用于根据从输入装置提供的输入数据构成缝纫机缝纫程序的缝制程序组合装置。 当输入装置在两个或多个不同的操作过程中操作时，缝制程序组合装置基于从输入装置提供的输入数据构成相同的缝制程序。

    Main-presser driving apparatus for automatic binding sewing machine
    6.
    发明授权
    Main-presser driving apparatus for automatic binding sewing machine 失效
    自动缝纫机主压机驱动装置

    公开(公告)号：US5211119A

    公开(公告)日：1993-05-18

    申请号：US955273

    申请日：1992-10-01

    申请人： Yuji Tagawa ,  Takashi Kondou ,  Shigeru Abe ,  Kazushi Inoue

    发明人： Yuji Tagawa ,  Takashi Kondou ,  Shigeru Abe ,  Kazushi Inoue

    IPC分类号： D05B3/10 ,  D05B21/00 ,  D05B35/04

    CPC分类号： D05B35/04

    摘要： A main-presser driving apparatus for an automatic binding sewing machine including two sewing needles for carrying out a binding sewing operation and a pair of main pressers for pressing a base cloth on which a binding cloth is to be sewn, the main pressers being supported by a frame of the sewing machine such that the two pressers are opposed to each other and are movable independently of each other along a directional line in which the two pressers advance toward, and retract away from, each other, the driving apparatus including a pair of drive devices each of which includes an actuator for displacing a corresponding one of the main pressers in the above-indicated direction independently of the other of the main pressers, each actuator being controllable to be stopped at a desired operational position; a needle distance specifying device specifying a distance between the two sewing needles; a control command producing device producing, based on the specified needle distance, a control command for each of the two actuators of said pair of drive means; and a control device driving each of the two actuators according to the produced control command and thereby displacing a corresponding one of the two main pressers along said directional line to a position corresponding to the produced control command.

    摘要翻译： 一种用于自动装订缝纫机的主压力驱动装置，包括用于执行装订缝合操作的两个缝纫针和用于对要缝制布料的基布进行按压的一对主压脚，主压脚由 所述缝纫机的框架使得所述两个按压件彼此相对并且可沿着所述两个压脚彼此前进并从其缩回的方向线彼此独立地移动，所述驱动装置包括一对 驱动装置，每个驱动装置包括用于独立于主压件中的另一个而沿上述方向移动相应的一个主压脚的致动器，每个致动器可控制地停在期望的操作位置; 针距离指定装置，其指定两个缝针之间的距离; 控制指令产生装置，根据指定的针距产生用于所述一对驱动装置的两个致动器中的每一个的控制命令; 以及控制装置，根据所产生的控制命令驱动两个致动器中的每一个，从而使沿着所述方向线的两个主压力机中的对应的一个位移到与所产生的控制命令相对应的位置。

    Cyclin D binding factor, and uses thereof
    7.
    发明授权
    Cyclin D binding factor, and uses thereof 失效
    细胞周期蛋白D结合因子及其用途

    公开(公告)号：US06180763B2

    公开(公告)日：2001-01-30

    申请号：US08928941

    申请日：1997-09-12

    申请人： Charles J. Sherr ,  Hiroshi Hirai ,  Kazushi Inoue ,  Sara M. Bodner

    发明人： Charles J. Sherr ,  Hiroshi Hirai ,  Kazushi Inoue ,  Sara M. Bodner

    IPC分类号： C07K122

    CPC分类号： C07K14/4705 ,  A01K2217/05 ,  A01K2217/075 ,  C07K2319/00

    摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

    摘要翻译： 本发明公开了D型细胞周期蛋白与与细胞周期蛋白D2特异性相互作用的新型myb样转录因子DMP1之间的直接相互作用。 本发明还提供了D型细胞周期蛋白以不依赖RB的方式调节基因表达的证据。 还包括DMP1，转录因子由包含三个非典型myb重复的中心DNA结合结构域组成，其侧翼为位于其氨基末端和羧基末端的高度酸性的片段。 本发明包括编码DMP1的氨基酸序列，以及编码氨基酸序列的DNA和RNA核苷酸序列。 公开了DMP1作为转录因子的用途，因为它在与含有非标记共有序列CCCG（G / T）ATGT的寡核苷酸的结合中具有特异性。 在本发明的这个方面，当转染到哺乳动物细胞中时，DMP1激活由含有连接的DMP1结合位点的最小启动子驱动的报道基因的转录。

    Sewing machine system
    8.
    发明授权
    Sewing machine system 失效
    缝纫机系统

    公开(公告)号：US6000351A

    公开(公告)日：1999-12-14

    申请号：US87110

    申请日：1998-05-29

    申请人： Shinii Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    发明人： Shinii Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    IPC分类号： D05B19/08 ,  D05B21/00

    CPC分类号： D05B19/085

    摘要： A sewing machine system provided with an electronically controlled sewing machine and a programmer, which is electronically connected to the sewing machine, for creating a sewing data in cooperation with the sewing machine. A selecting switch is provided and, when sewing data is being created, a user can switch a display condition of a displaying device of the programmer between a first mode for displaying numerical data related to currently created sewing data, and a second mode for displaying an image of the pattern in accordance with the sewing data which is being created.

    摘要翻译： 一种缝纫机系统，其具有与缝纫机电子连接的电子控制缝纫机和编程器，用于与缝纫机协作创建缝制数据。 提供选择开关，并且当缝制数据被创建时，用户可以在用于显示与当前创建的缝制数据相关的数字数据的第一模式和用于显示当前创建的缝合数据的第二模式之间切换编程器的显示装置的显示状态 根据正在创建的缝制数据的图案的图像。

    Programmable electronic sewing machine
    9.
    发明授权
    Programmable electronic sewing machine 失效
    可编程电子缝纫机

    公开(公告)号：US5899158A

    公开(公告)日：1999-05-04

    申请号：US84226

    申请日：1998-05-26

    申请人： Shinji Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    发明人： Shinji Yoshida ,  Kazushi Inoue ,  Yoshihiro Hara ,  Minoru Yamaguchi

    IPC分类号： D05B19/02 ,  D05B19/08 ,  D05B19/12 ,  D05B69/18

    CPC分类号： D05B19/085 ,  D05B19/12

    摘要： A programmable electronic sewing machine includes sewing control means for controlling sections of the machine including a main shaft on the basis of a preset program so that a sewing operation is executed, rotational speed setting means for setting a rotational speed of the main shaft according to an amount of operation thereof, upper limit calculating means for calculating an upper limit settable as the rotational speed of the main shaft on the basis of the preset program, and displaying means for displaying the rotational speed of the main shaft currently set by the rotational speed setting means with the upper limit calculated by the upper limit calculating means serving as an upper limit of the displayed rotational speed.

    摘要翻译： 一种可编程电子缝纫机包括缝制控制装置，用于基于预设程序控制包括主轴的机器的部分，从而执行缝纫操作;转速设定装置，用于根据主轴设置主轴的转速; 其操作量，上限计算装置，用于基于预设程序计算可设定为主轴的转速的上限;以及显示装置，用于显示当前由转速设定设定的主轴的转速 具有由上限计算装置计算的上限作为显示的旋转速度的上限的装置。

    Cyclin D binding factor, and uses thereof
    10.
    发明授权
    Cyclin D binding factor, and uses thereof 有权

    公开(公告)号：US06303772B1

    公开(公告)日：2001-10-16

    申请号：US09280590

    申请日：1999-03-29

    申请人： Charles J. Sherr ,  Hiroshi Hirai ,  Sara M. Bodner ,  Kazushi Inoue

    发明人： Charles J. Sherr ,  Hiroshi Hirai ,  Sara M. Bodner ,  Kazushi Inoue

    IPC分类号： C07K122

    CPC分类号： C07K14/4705 ,  A01K2217/05 ,  A01K2217/075 ,  C07K2319/00

    摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.