公开(公告)号：US06726926B2

公开(公告)日：2004-04-27

申请号：US09790727

申请日：2001-02-23

申请人： Haruyoshi Yajima ,  Keizo Sakuda ,  Hideshi Ideno ,  Kunio Yagi ,  Nobuko Ohishi ,  Jun Yoshida

发明人： Haruyoshi Yajima ,  Keizo Sakuda ,  Hideshi Ideno ,  Kunio Yagi ,  Nobuko Ohishi ,  Jun Yoshida

IPC分类号： A61K9127

CPC分类号： A61K31/711 ,  A61K9/1271 ,  A61K9/1272 ,  C12N15/88

摘要： It provides a gene-entrapping liposome preparation which can be preserved over a long period of time, and a process for the preparation of the same. The preparation can be prepared by adding an aqueous solution of disaccharide to gene-entrapping liposomes. The frozen preparation can be preserved for 6 months or more at preservation temperature of −20° C., and the preparation shows excellent restoration ability in water and does not show reduction in biological activity. In the case of the lyophilized preparation, it can be preserved for longer time of about 1 year, shows excellent restoration ability in water, and does not show reduction in biological activity.

摘要翻译： 它提供了可以长期保存的基因捕获脂质体制剂及其制备方法。 该制剂可以通过将二糖水溶液加入到基因捕获的脂质体中来制备。 冷冻制剂可在-20℃的保存温度下保存6个月以上，该制剂在水中显示出优异的恢复能力，并且不显示出生物活性的降低。 在冻干制剂的情况下，其可以保存较长时间约1年，在水中显示出优异的恢复能力，并且不显示生物活性的降低。