公开(公告)号：US09084570B2

公开(公告)日：2015-07-21

申请号：US12901078

申请日：2010-10-08

申请人： Harvey Buck ,  Georgeta Lica ,  Karl-Heinz Koelker ,  Ewald Rieger

发明人： Harvey Buck ,  Georgeta Lica ,  Karl-Heinz Koelker ,  Ewald Rieger

IPC分类号： A61B5/05 ,  A61B5/04 ,  A61B5/1473 ,  G01N27/327

CPC分类号： A61B5/1477 ,  A61B5/1473 ,  A61B2560/0468 ,  A61B2562/043 ,  G01N27/327

摘要： The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

摘要翻译： 本发明提供一种电化学传感器，其采用暴露于与体液接触的多个电极区域，例如当传感器被皮下插入患者皮肤时。 暴露的电极区域对称地布置，使得当将AC信号施加到传感器时产生对称的电位分布。 根据这些教导的传感器可以有利地与AC信号一起使用以确定传感器的特性，从而提高传感器性能。 这些教导还提供具有暴露于体液接触的多个参考电极区域的生物相容性传感器。

公开(公告)号：US20120088993A1

公开(公告)日：2012-04-12

申请号：US12901078

申请日：2010-10-08

申请人： Harvey Buck ,  Georgeta Lica ,  Karl-Heinz Koelker ,  Ewald Rieger

发明人： Harvey Buck ,  Georgeta Lica ,  Karl-Heinz Koelker ,  Ewald Rieger

IPC分类号： A61B5/1468

CPC分类号： A61B5/1477 ,  A61B5/1473 ,  A61B2560/0468 ,  A61B2562/043 ,  G01N27/327

摘要： The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

摘要翻译： 本发明提供一种电化学传感器，其采用暴露于与体液接触的多个电极区域，例如当传感器被皮下插入患者皮肤时。 暴露的电极区域对称地布置，使得当将AC信号施加到传感器时产生对称的电位分布。 根据这些教导的传感器可以有利地与AC信号一起使用以确定传感器的特性，从而提高传感器性能。 这些教导还提供具有暴露于体液接触的多个参考电极区域的生物相容性传感器。

公开(公告)号：US20110168575A1

公开(公告)日：2011-07-14

申请号：US12684277

申请日：2010-01-08

申请人： Georgeta Lica ,  Harvey B. Buck ,  Henning Groll

发明人： Georgeta Lica ,  Harvey B. Buck ,  Henning Groll

IPC分类号： G01N27/26

CPC分类号： G01N27/3274

摘要： One aspect concerns a technique for detecting analyte concentrations, such as glucose concentrations, in blood or other bodily fluids. This technique utilizes an electrochemical test strip that includes a mediator system that generates a linear faradic response at relatively low applied potential differences. An alternating current excitation signal is applied to blood in the test strip. The alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal. The glucose concentration is determined by measuring a low frequency response to the low frequency signal, measuring a high frequency response to the high frequency signal, estimating the glucose concentration based on the low frequency response, and correcting the glucose concentration for one or more error-causing variables based on the high frequency response.

摘要翻译： 一方面涉及用于检测血液或其他体液中的分析物浓度，例如葡萄糖浓度的技术。 该技术利用电化学测试条，其包括在相对低的施加电位差下产生线性法拉第响应的介体系统。 交流电激励信号被施加到测试条中的血液。 交流励磁信号包括低频信号和具有比低频信号更高频率的高频信号。 葡萄糖浓度通过测量对低频信号的低频响应，测量对高频信号的高频响应，基于低频响应估计葡萄糖浓度，以及校正一个或多个误差信号的葡萄糖浓度， 导致基于高频响应的变量。

公开(公告)号：US08691075B2

公开(公告)日：2014-04-08

申请号：US12649929

申请日：2009-12-30

申请人： Georgeta Lica

发明人： Georgeta Lica

IPC分类号： G01N33/487

CPC分类号： G01N27/3273

摘要： The blood glucose analysis technique and system described herein address the issue of hematocrit interference when rapidly detecting glucose concentrations. It addresses this issue by using a differential pulse voltammetry technique in which short high, frequency voltage pulses are applied to keep the diffusion layer within the reagent of the working electrode, and the pulses are applied in a limited voltage window (or range) that is below the peak, diffusion-limited current. The readings below the peak are then used to determine glucose concentrations. With this technique, glucose concentrations can be determined relatively fast (e.g., within 5 seconds) and independently of the hematocrit levels of the fluid being analyzed.

摘要翻译： 本文所述的血糖分析技术和系统在快速检测葡萄糖浓度时解决了血细胞比容干扰的问题。 它通过使用差分脉冲伏安法技术来解决这个问题，其中施加短高的频率电压脉冲以将扩散层保持在工作电极的试剂内，并且脉冲被施加在有限的电压窗口（或范围） 低于峰值，扩散受限电流。 然后将低于峰值的读数用于测定葡萄糖浓度。 利用这种技术，葡萄糖浓度可以相对快速地（例如在5秒内）来确定，并且与被分析的流体的血细胞比容水平无关。

公开(公告)号：US20110155588A1

公开(公告)日：2011-06-30

申请号：US12649929

申请日：2009-12-30

申请人： Georgeta Lica

发明人： Georgeta Lica

IPC分类号： G01N27/327

CPC分类号： G01N27/3273

摘要： The blood glucose analysis technique and system described herein address the issue of hematocrit interference when rapidly detecting glucose concentrations. It addresses this issue by using a differential pulse voltammetry technique in which short high, frequency voltage pulses are applied to keep the diffusion layer within the reagent of the working electrode, and the pulses are applied in a limited voltage window (or range) that is below the peak, diffusion-limited current. The readings below the peak are then used to determine glucose concentrations. With this technique, glucose concentrations can be determined relatively fast (e.g., within 5 seconds) and independently of the hematocrit levels of the fluid being analyzed.

摘要翻译： 本文所述的血糖分析技术和系统在快速检测葡萄糖浓度时解决了血细胞比容干扰的问题。 它通过使用差分脉冲伏安法技术来解决这个问题，其中施加短高的频率电压脉冲以将扩散层保持在工作电极的试剂内，并且脉冲被施加在有限的电压窗口（或范围） 低于峰值，扩散受限电流。 然后将低于峰值的读数用于测定葡萄糖浓度。 利用这种技术，葡萄糖浓度可以相对快速地（例如在5秒内）来确定，并且与被分析的流体的血细胞比容水平无关。