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1.发明授权T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US08354232B2
公开(公告)日：2013-01-15
申请号：US12840015
申请日：2010-07-20
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor I. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor I. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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2.发明授权T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US07759062B2
公开(公告)日：2010-07-20
申请号：US11811544
申请日：2007-06-11
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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3.发明申请T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US20080131870A1
公开(公告)日：2008-06-05
申请号：US11811544
申请日：2007-06-11
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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4.发明申请公开(公告)号：US20100285488A1
公开(公告)日：2010-11-11
申请号：US12840015
申请日：2010-07-20
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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公开(公告)号：US08071750B2
公开(公告)日：2011-12-06
申请号：US12346322
申请日：2008-12-30
申请人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
发明人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
IPC分类号： C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.
摘要翻译： 本发明提供用于检测和表征HCV序列的组合物和方法。 更具体地，本发明提供了用于使用侵入性切割结构测定（例如INVADER测定）来筛选例如来自患者的核酸样品以确定HCV基因型的组合物，方法和试剂盒。
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公开(公告)号：US20090111092A1
公开(公告)日：2009-04-30
申请号：US12346322
申请日：2008-12-30
申请人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
发明人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.
摘要翻译： 本发明提供用于检测和表征HCV序列的组合物和方法。 更具体地，本发明提供了用于使用侵入性切割结构测定（例如INVADER测定）来筛选例如来自患者的核酸样品以确定HCV基因型的组合物，方法和试剂盒。
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公开(公告)号：US07473773B2
公开(公告)日：2009-01-06
申请号：US11031487
申请日：2005-01-07
申请人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
发明人： Vecheslav A. Elagin , Scott M. Law , Bjork Hill
IPC分类号： C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.
摘要翻译： 本发明提供用于检测和表征HCV序列的组合物和方法。 更具体地，本发明提供了用于使用侵入性切割结构测定（例如INVADER测定）来筛选例如来自患者的核酸样品以确定HCV基因型的组合物，方法和试剂盒。
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公开(公告)号：US09249455B2
公开(公告)日：2016-02-02
申请号：US12425088
申请日：2009-04-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6818 , C12Q2525/207 , C12Q2525/117
摘要： Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.
摘要翻译： 公开了用于检测样品中的小RNA分子如微RNA和siRNA的方法，试剂盒和组分。 该方法利用包含非天然碱基的引物和报道分子。 所公开的套件可以包括用于执行所公开的方法的一个或多个组件。
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公开(公告)号：US20090275039A1
公开(公告)日：2009-11-05
申请号：US12425088
申请日：2009-04-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6818 , C12Q2525/207 , C12Q2525/117
摘要： Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.
摘要翻译： 公开了用于检测样品中的小RNA分子如微RNA和siRNA的方法，试剂盒和组分。 该方法利用包含非天然碱基的引物和报道分子。 所公开的套件可以包括用于执行所公开的方法的一个或多个组件。
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