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1.发明授权T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US07759062B2
公开(公告)日：2010-07-20
申请号：US11811544
申请日：2007-06-11
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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2.发明申请T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US20080131870A1
公开(公告)日：2008-06-05
申请号：US11811544
申请日：2007-06-11
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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3.发明申请公开(公告)号：US20100285488A1
公开(公告)日：2010-11-11
申请号：US12840015
申请日：2010-07-20
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor A. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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4.发明授权T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection 有权T结构侵入性切割测定，一致的核酸分配和低水平靶核酸检测公开(公告)号：US08354232B2
公开(公告)日：2013-01-15
申请号：US12840015
申请日：2010-07-20
申请人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor I. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
发明人： Hatim Taysir Allawi , Vecheslav A. Elagin , Victor I. Lyamichev , Kwok Wu , Walter Iszczyszyn , Chris Fleming , LuAnne Chehak , Scott M. Law
CPC分类号： C12Q1/6823 , C12Q1/70 , C12Q2521/301 , C12Q2525/301
摘要： The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.
摘要翻译： 本发明涉及用于低水平检测核酸的系统，方法和试剂盒，在单个反应容器中检测至少两种不同的病毒序列，并增加样品中病毒靶核酸的动态检测范围。 本发明还涉及T结构侵入性切割测定，以及T结构相关靶依赖性非靶扩增方法和组合物。 本发明还涉及用于将一致的核酸分配到表面上的方法，组合物，装置和系统。
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5.发明申请Nucleic Acid Accessible Hybridization Site Identification Using Mass Spectrometry 审中-公开使用质谱的核酸可接近杂交现场鉴定公开(公告)号：US20090075256A1
公开(公告)日：2009-03-19
申请号：US11763742
申请日：2007-06-15
CPC分类号： C12Q1/6832 , C12Q1/6811 , C12Q1/6848 , Y10T436/143333 , C12Q2565/627 , C12Q2565/133
摘要： The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure using mass spectrometry.
摘要翻译： 本发明涉及用于分析核酸的方法和组合物，特别涉及使用质谱法检测和表征核酸序列和序列变化的方法和组合物。 本发明还提供用于使用质谱法鉴定含有二级结构的核酸靶的具有期望的杂交性质的寡核苷酸的方法和组合物。
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公开(公告)号：US06759226B1
公开(公告)日：2004-07-06
申请号：US09577304
申请日：2000-05-24
申请人： Wu-Po Ma , Victor I. Lyamichev , Michael W. Kaiser , Natalie E. Lyamicheva , Hatim Taysir Allawi , James J. Schaefer , Bruce P. Neri
发明人： Wu-Po Ma , Victor I. Lyamichev , Michael W. Kaiser , Natalie E. Lyamicheva , Hatim Taysir Allawi , James J. Schaefer , Bruce P. Neri
IPC分类号： C12N922
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that cleave the nucleic acid cleavage structure in a site-specific manner to produce non-target cleavage products. The present invention provides enzymes having an improved ability to specifically cleave a DNA member of a complex comprising DNA and RNA nucleic acid strands.
摘要翻译： 本发明涉及设计用于直接检测，表征和定量核酸，特别是RNA的新型酶。 本发明提供了识别在靶RNA序列上形成的特异性核酸切割结构并以位点特异性方式切割核酸切割结构以产生非靶切割产物的酶。 本发明提供具有改进的能够特异性切割包含DNA和RNA核酸链的复合物的DNA成员的酶的酶。
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公开(公告)号：US06635463B2
公开(公告)日：2003-10-21
申请号：US09758282
申请日：2001-01-11
申请人： Wu-Po Ma , Victor I. Lyamichev , Michael W. Kaiser , Natalie E. Lyamicheva , Hatim Taysir Allawi , James J. Schaefer , Bruce P. Neri
发明人： Wu-Po Ma , Victor I. Lyamichev , Michael W. Kaiser , Natalie E. Lyamicheva , Hatim Taysir Allawi , James J. Schaefer , Bruce P. Neri
IPC分类号： C12N922
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that cleave the nucleic acid cleavage structure in a site-specific manner to produce non-target cleavage products. The present invention provides enzymes having an improved ability to specifically cleave a DNA member of a complex comprising DNA and RNA nucleic acid strands.
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