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    Composition for improving calcium metabolism
    6.
    发明授权
    Composition for improving calcium metabolism 失效
    用于改善钙代谢的组合物

    公开(公告)号：US5756488A

    公开(公告)日：1998-05-26

    申请号：US655973

    申请日：1996-05-31

    申请人： Sachiko Yamada

    发明人： Sachiko Yamada

    IPC分类号： A61K31/59 ,  A61P3/02 ,  A61P3/14 ,  C07C401/00

    CPC分类号： A61K31/593

    摘要： A composition for improving calcium metabolism comprising, as an active ingredient, (20S,22R)-22-methyl-1.alpha.,25-dihydroxyvitamin D.sub.3 ; and a method of treating a calcium metabolism disorder in a mammal comprising administering a therapeutically effective amount of (20S,22R)-22-methyl-1.alpha.,25-dihydroxyvitamin D.sub.3.

    摘要翻译： 一种用于改善钙代谢的组合物，其包含作为活性成分的（20S，22R）-22-甲基-1α，25-二羟基维生素D 3; 和治疗哺乳动物钙代谢紊乱的方法，包括给予治疗有效量的（20S，22R）-22-甲基-1α，25-二羟基维生素D3。

    Labelled vitamin D.sub.3 derivative and production process thereof
    7.
    发明授权
    Labelled vitamin D.sub.3 derivative and production process thereof 失效
    标签维生素D3衍生物及其生产方法

    公开(公告)号：US5116573A

    公开(公告)日：1992-05-26

    申请号：US403466

    申请日：1989-09-07

    申请人： Sachiko Yamada ,  Koichi Niimura ,  Kenji Fukushima ,  Yuji Maeda

    发明人： Sachiko Yamada ,  Koichi Niimura ,  Kenji Fukushima ,  Yuji Maeda

    IPC分类号： A61K31/59 ,  A61P3/02 ,  A61P19/10 ,  A61P43/00 ,  C07B59/00 ,  C07C67/00 ,  C07C401/00

    CPC分类号： C07C401/00

    摘要： The present invention discloses a novel, labelled vitamin D.sub.3 derivative in which hydrogen atoms on the skeleton portion, i.e. 6- and 19-positions, are substituted with a deuterium atom or a tritium atom, as well as a novel production process of the labelled vitamin D.sub.3 derivative carried out by way of sulfur dioxide addition reaction of a vitamin D.sub.3 derivative. The labelled portion of the novel vitamin D.sub.3 is resistant against in vivo metabolism and make a long period tracing of its pharmacodynamics in a living body possible.

    摘要翻译： 本发明公开了一种新颖的标记的维生素D3衍生物，其中骨架部分上的氢原子，即6位和19位被氘原子或氚原子取代，以及标记维生素的新生产方法 D3衍生物通过维生素D3衍生物的二氧化硫加成反应进行。 新维生素D3的标记部分对体内代谢具有抗性，并且可以长时间地追踪其活体内的药效学。

    Novel vitamin D.sub.3 derivatives and process for producing the same
    8.
    发明授权
    Novel vitamin D.sub.3 derivatives and process for producing the same 失效
    新型维生素D3衍生物及其制备方法

    公开(公告)号：US4517125A

    公开(公告)日：1985-05-14

    申请号：US463616

    申请日：1983-02-03

    申请人： Hiroaki Takayama ,  Sachiko Yamada ,  Keiko Nakayama ,  Tatsuo Suda

    发明人： Hiroaki Takayama ,  Sachiko Yamada ,  Keiko Nakayama ,  Tatsuo Suda

    IPC分类号： C07C401/00 ,  C07D319/02 ,  C07J9/00

    CPC分类号： C07D319/02 ,  C07C401/00

    摘要： There are disclosed 6,19-epidioxyvitamin D.sub.3 derivatives which are represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom or a hydroxyl group; when R.sub.1 is a hydrogen atom, R.sub.2 represents a hydroxyl group and R.sub.3 is a hydrogen atom or a hydroxyl group; when both R.sub.1 and R.sub.2 represent a hydroxyl group, R.sub.3 is a hydrogen atom or a hydroxyl group; and when R.sub.1 is a hydroxyl group and R.sub.2 is a hydrogen atom, R.sub.3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.

    摘要翻译： 公开了由式（1）表示的6,19-表维生素D3衍生物，其中R1，R2和R3各自为氢原子或羟基; 当R 1是氢原子时，R 2表示羟基，R 3是氢原子或羟基; 当R1和R2都表示羟基时，R3是氢原子或羟基; 当R 1为羟基且R 2为氢原子时，R 3表示羟基。 该化合物能够以最小的钙代谢作用诱导人类骨髓性白血病细胞的分化，并且可用作治疗白血病的药剂。