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1.发明申请APPARATUS, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR THERAPY PLANNING IN TREATMENT OF A PATIENT 失效装置，方法，计算机可读介质和用于治疗患者的治疗方案公开(公告)号：US20090292481A1
公开(公告)日：2009-11-26
申请号：US12446989
申请日：2007-11-06
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , G06F19/00
摘要： An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.
摘要翻译： 提供了一种装置，方法，系统，计算机可读介质以及用于各种患者治疗计划疾病如癌症的不同治疗方式（如放射治疗和化疗）的用途。 本发明的新方面是患者的骨髓抑制程度与每次治疗前测量的未成熟血小板计数有关。 本发明的一些实施方案提供了一种优点，可以降低预测骨髓抑制风险的不确定性水平，从而能够通过增加单个患者的辐射剂量和/或化学剂量来安全地改善治疗效果 而骨髓抑制的风险最小化。
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2.发明授权Apparatus, method, computer-readable medium, and use for therapy planning in treatment of a patient 失效装置，方法，计算机可读介质，以及用于治疗患者的治疗计划公开(公告)号：US08315810B2
公开(公告)日：2012-11-20
申请号：US12446989
申请日：2007-11-06
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , G06F19/00
摘要： An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.
摘要翻译： 提供了一种装置，方法，系统，计算机可读介质以及用于各种患者治疗计划疾病如癌症的不同治疗方式（如放射治疗和化疗）的用途。 本发明的新方面是患者的骨髓抑制程度与每次治疗前测量的未成熟血小板计数有关。 本发明的一些实施方案提供了一种优点，可以降低预测骨髓抑制风险的不确定性水平，从而能够通过增加单个患者的辐射剂量和/或化学剂量来安全地改善治疗效果 而骨髓抑制的风险最小化。
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公开(公告)号：US09248313B2
公开(公告)日：2016-02-02
申请号：US13256767
申请日：2010-02-18
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译： 治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。 规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物生成患者特异性自适应放射治疗计划。 确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。 辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。 确定第二组患者特异性生物标志物。 使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。 辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。
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公开(公告)号：US20120004492A1
公开(公告)日：2012-01-05
申请号：US13256767
申请日：2010-02-18
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译： 治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。 规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物生成患者特异性自适应放射治疗计划。 确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。 辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。 确定第二组患者特异性生物标志物。 使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。 辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。
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