公开(公告)号：US20100310686A1

公开(公告)日：2010-12-09

申请号：US12734597

申请日：2008-11-14

Applicant: Manuel Gidegel ,  Helga Weber ,  Gustavo Cabrera ,  Ana Gutierrez ,  Jennifer Osorio ,  Jose Becera ,  Osvaldo Podhajcer ,  Eduardo Cafferata ,  Carlos Sunkel ,  Ivan Mihovilovic

Inventor： Manuel Gidegel ,  Helga Weber ,  Gustavo Cabrera ,  Ana Gutierrez ,  Jennifer Osorio ,  Jose Becera ,  Osvaldo Podhajcer ,  Eduardo Cafferata ,  Carlos Sunkel ,  Ivan Mihovilovic

IPC: A61K36/899

CPC classification number: A61K36/899

Abstract: The present disclosure provides a novel antineoplastic extract obtained from Deschampsia antarctica plant. Active components of the antineoplastic extract are also disclosed and a method to prevent proliferation of cancerous or tumorous cells with the extract or with components thereof is disclosed. Furthermore, a method to induce production of active ingredients in in vitro grown plants by submitting the plants to physical or chemical treatements before preparing the antineoplastic extract is disclosed. This disclosure provides compostions of tablets and pellets for treating patients with cancer or for prevention of occurence of cancerous diseases.

Abstract translation: 本公开提供从南极洲南极洲植物获得的新型抗肿瘤提取物。 还公开了抗肿瘤提取物的活性成分，并公开了用提取物或其组分防止癌细胞或肿瘤细胞增殖的方法。 此外，公开了在制备抗肿瘤提取物之前通过将植物提交给物理或化学处理来诱导在体外生长的植物中生产活性成分的方法。 本公开提供用于治疗癌症患者或预防癌性疾病发生的片剂和小丸的组合物。

公开(公告)号：US07013189B2

公开(公告)日：2006-03-14

申请号：US10297975

申请日：2001-06-02

Applicant: Helga Weber

Inventor： Helga Weber

IPC: G06F19/00 ,  G06F17/50

CPC classification number: G05B19/40937 ,  G05B2219/31325 ,  G05B2219/32175 ,  G05B2219/32248 ,  G05B2219/36284 ,  G05B2219/36302 ,  Y02P90/20 ,  Y02P90/265

Abstract: A method for automatically preparing a working plan for producing a product having several components. The method involves the following steps: a) providing a product data model of the product, in which each component is described by a partial data set containing a classification characteristic; b) preparing a database, whereby the data sets contained therein are divided into classes according to the classification characteristic, whereby each class contains one or more selection rules, whereby a manufacturing partial process provided with an index is assigned to each selection rule, and each manufacturing partial process contains one or more working cycles; c) automatically selecting the class applying to the component by using the classification characteristic; d) automatically selecting a manufacturing partial process suited for producing the component by using the selection rule; e) automatically establishing the sequence of the manufacturing partial processes by using the respective index.

Abstract translation: 一种用于自动准备用于生产具有多个部件的产品的工作计划的方法。 该方法包括以下步骤：a）提供产品的产品数据模型，其中每个组件由包含分类特征的部分数据集描述; b）准备数据库，由此根据分类特征将其中包含的数据集划分为类，由此每个类包含一个或多个选择规则，由此向每个选择规则分配具有索引的制造部分处理，并且每个 制造部分过程包含一个或多个工作循环; c）使用分类特征自动选择应用于组件的类; d）通过使用选择规则自动选择适合于生产部件的制造部分过程; e）通过使用相应的索引自动建立制造部分过程的序列。

公开(公告)号：US09056133B2

公开(公告)日：2015-06-16

申请号：US13506865

申请日：2012-05-21

Applicant: Osvaldo Podhajcer ,  Manuel Gidekel ,  Eduardo Cafferata ,  Helga Weber

Inventor： Osvaldo Podhajcer ,  Manuel Gidekel ,  Eduardo Cafferata ,  Helga Weber

IPC: A61K48/00 ,  A61K31/7068 ,  A61K38/46 ,  A61K35/761

CPC classification number: A61K48/0058 ,  A61K31/7068 ,  A61K35/761 ,  A61K38/465 ,  A61K2300/00

Abstract: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.

Abstract translation: 本发明涉及癌症治疗领域，更具体地涉及与合适的化学治疗剂组合的基因疗法。 本发明涉及能够抑制恶性肿瘤生长或者是过度增殖性哺乳动物细胞的治疗或者是癌症治疗的新的溶瘤病毒。 溶瘤病毒与合适的化学治疗剂组合起作用。 更具体地，本发明提供了包含溶瘤腺病毒和化学治疗剂的药物试剂盒，以及用于治疗癌症的方法。

公开(公告)号：US20110177178A1

公开(公告)日：2011-07-21

申请号：US12928317

申请日：2010-12-08

Applicant: Manuel Gidekel ,  Helga Weber ,  Gustavo Cabrera ,  Ana Gutierrez ,  Jennifer Osorio ,  Osvaldo Podhajcer ,  Eduardo Cafferata ,  Carlos Sunkel ,  Ivan Mihovilovic

Inventor： Manuel Gidekel ,  Helga Weber ,  Gustavo Cabrera ,  Ana Gutierrez ,  Jennifer Osorio ,  Osvaldo Podhajcer ,  Eduardo Cafferata ,  Carlos Sunkel ,  Ivan Mihovilovic

IPC: A61K36/899 ,  A61P35/00

CPC classification number: A61K36/899

Abstract: This invention describes antineoplastic compound derived from Deschampsia antarctica plants. The biologically active compounds are further characterized. The described compounds are demonstrated to have a capacity to inhibit cancer cell proliferation.

Abstract translation: 本发明描述了源自南极洲南极洲植物的抗肿瘤化合物。 进一步表征生物活性化合物。 所述化合物被证明具有抑制癌细胞增殖的能力。