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公开(公告)号：US20200261486A1
公开(公告)日：2020-08-20
申请号：US16275531
申请日：2019-02-14
IPC分类号： A61K31/7048 , A61P35/00 , A61K35/30
摘要： Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-β-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-β-D-glucopyranoside derivatives. Tricin 7-O-β-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-β-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.
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公开(公告)号：US09426950B2
公开(公告)日：2016-08-30
申请号：US13694381
申请日：2012-11-27
申请人： Manuel Gidekel
发明人： Manuel Gidekel
CPC分类号： A01G31/06 , Y02P60/216
摘要： This invention discloses a process for the propagation and survival of Deschampsia antarctica suitable for industrial scale production. In particular, the process defines selected bioreactor conditions whereby morphologically high quality plants are obtained at high rates. This invention further discloses a bioreactor design which includes a design for automated temporary immersion of explants in a culture medium.
摘要翻译： 本发明公开了适用于工业规模生产的南极洲南极洲的传播和存活方法。 特别地，该方法定义了选择的生物反应器条件，从而以高速率获得形态上高质量的植物。 本发明还公开了一种生物反应器设计，其包括用于在培养基中自动临时浸入外植体的设计。
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公开(公告)号：US07273931B2
公开(公告)日：2007-09-25
申请号：US11639474
申请日：2006-12-15
申请人： Manuel Gidekel , Ana Gutierrez , Leal Pamela , Luis Destefano-Beltran , Jorge Dinamarca , Emilio Guerra
发明人： Manuel Gidekel , Ana Gutierrez , Leal Pamela , Luis Destefano-Beltran , Jorge Dinamarca , Emilio Guerra
CPC分类号： C12N15/8237 , C07K14/415 , C12N15/8273
摘要： This disclosure provides gene sequence of a novel gene DaRub1 of Deschampsia antarctica expressed at low temperatures. The promoter sequence of this gene is identified and characterized. The promoter is inducible at low temperature, upon wounding and after auxin-treatment. Additionally this disclosure shows improved low temperature tolerance of transgenic Eucalyptus plants expressing DaRub1 gene.
摘要翻译： 本公开提供了在低温下表达的南极洲南极Des a新基因DaRub1的基因序列。 鉴定和表征该基因的启动子序列。 启动子可在低温，伤口和生长素处理后诱导。 此外，该公开内容显示了表达DaRub1基因的转基因桉树植物的低温耐受性的改善。
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4.发明申请公开(公告)号：US20110177178A1
公开(公告)日：2011-07-21
申请号：US12928317
申请日：2010-12-08
申请人： Manuel Gidekel , Helga Weber , Gustavo Cabrera , Ana Gutierrez , Jennifer Osorio , Osvaldo Podhajcer , Eduardo Cafferata , Carlos Sunkel , Ivan Mihovilovic
发明人： Manuel Gidekel , Helga Weber , Gustavo Cabrera , Ana Gutierrez , Jennifer Osorio , Osvaldo Podhajcer , Eduardo Cafferata , Carlos Sunkel , Ivan Mihovilovic
IPC分类号： A61K36/899 , A61P35/00
CPC分类号： A61K36/899
摘要： This invention describes antineoplastic compound derived from Deschampsia antarctica plants. The biologically active compounds are further characterized. The described compounds are demonstrated to have a capacity to inhibit cancer cell proliferation.
摘要翻译： 本发明描述了源自南极洲南极洲植物的抗肿瘤化合物。 进一步表征生物活性化合物。 所述化合物被证明具有抑制癌细胞增殖的能力。
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公开(公告)号：US07622109B2
公开(公告)日：2009-11-24
申请号：US12316988
申请日：2008-12-18
申请人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
发明人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
IPC分类号： A61K38/46
摘要： A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as use for the enzyme in sunscreen.
摘要翻译： 公开了从编码脂肪酶类蛋白质的南极洲南极洲分离的新基因。 还公开了用于生产重组酶的系统以及用于防晒剂中的酶。
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公开(公告)号：US20090117062A1
公开(公告)日：2009-05-07
申请号：US12316988
申请日：2008-12-18
申请人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
发明人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
IPC分类号： A61Q17/04
摘要： A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as use for the enzyme in sunscreen.
摘要翻译： 公开了从编码脂肪酶类蛋白质的南极洲南极洲分离的新基因。 还公开了用于生产重组酶的系统以及用于防晒剂中的酶。
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公开(公告)号：US20080253977A1
公开(公告)日：2008-10-16
申请号：US11787383
申请日：2007-04-16
申请人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
发明人： Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
摘要： A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as uses for the enzyme.
摘要翻译： 公开了从编码脂肪酶类蛋白质的南极洲南极洲分离的新基因。 还公开了用于生产重组酶的系统以及该酶的用途。
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公开(公告)号：US10190181B2
公开(公告)日：2019-01-29
申请号：US15289103
申请日：2016-10-07
申请人： Manuel Gidekel
发明人： Manuel Gidekel
IPC分类号： A61K36/00 , C12R1/02 , A01N63/02 , C12N1/20 , C12R1/01 , B27K3/00 , A01N63/00 , C12R1/00 , A01N25/00
摘要： The present invention provides for a bio-nematocide for repairing damage to wood and related cellulosic products caused by nematodes.
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公开(公告)号：US20160174568A1
公开(公告)日：2016-06-23
申请号：US14120777
申请日：2014-06-26
申请人： Manuel Gidekel
发明人： Manuel Gidekel
摘要： The present invention provides for the first time a biological system which provides the dual function of killing termites and other wood damaging insects while also producing a by-product substance having the capability of repairing damage by termites and other insects to wood and related cellulosic products.The present invention, a biological system, toxic to termites, is provided which produces a means by which damage caused by termites is repaired, said means comprising a by-product produced by a modification of the bacteria of the genus Gluconacetobacter. Preferably, the biological system is in the form of toxic bait.
摘要翻译： 本发明首次提供了提供杀死白蚁和其他木材损伤昆虫的双重功能的生物系统，同时还生产具有修复白蚁和其他昆虫对木材和相关纤维素产品的损害能力的副产物物质。 提供了本发明的对白蚁有毒的生物系统，其产生了由白蚁引起的损伤被修复的手段，所述装置包括通过葡糖乙酸杆菌属细菌的修饰产生的副产物。 优选地，生物系统是有毒诱饵的形式。
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公开(公告)号：US20140328944A1
公开(公告)日：2014-11-06
申请号：US13986437
申请日：2013-05-02
IPC分类号： C12N15/113 , A61K33/24 , A61K31/704 , A61K31/7072
CPC分类号： C12N15/113 , A61K31/513 , A61K31/704 , A61K33/24 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要： This invention encompasses a novel composition comprising silenced CTBP-1 combined with a compound selected from among 5-FU, Cisplatin and Epirubicin. The invention further relates to a method of treating gastric cancer with a combination of siRNA silenced CTBP-1 and a compound selected from among 5-FU, Cisplatin and Epirubicin.
摘要翻译： 本发明包括一种包含沉默的CTBP-1与选自5-FU，顺铂和表柔比星的化合物的组合物。 本发明还涉及一种用siRNA沉默的CTBP-1和选自5-FU，顺铂和表柔比星的化合物组合治疗胃癌的方法。
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