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公开(公告)号：US20230321123A1
公开(公告)日：2023-10-12
申请号：US18042907
申请日：2021-08-24
发明人： Christian Ducho , Rolf W. Hartmann , Jörg Haupenthal , Anna K. H. Hirsch , Andreas Kany , Cansu Kaya , Jelena Konstantinovic , Katrin Voos , Isabell Walter , Samir Yahiaoui , Ahmed Saad Abdelsamine , Christian Schütz , Ravindra Jumde , Alexander Kiefer
IPC分类号： A61K31/675 , A61K45/06 , A61K31/662 , A61K31/428 , A61K31/426 , A61K31/381 , A61K31/4406 , A61K31/4184
CPC分类号： A61K31/675 , A61K45/06 , A61K31/662 , A61K31/428 , A61K31/426 , A61K31/381 , A61K31/4406 , A61K31/4184
摘要： The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.
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公开(公告)号：US20210353606A1
公开(公告)日：2021-11-18
申请号：US17257804
申请日：2019-07-03
发明人： Ahmed S.A. Ahmed , Martin Empting , Mostafa Hamed , Rolf W. Hartmann , Jörg Haupenthal , Thomas Hesterkamp , Ahmed A.M. Kamal , Christine K. Maurer , Teresa Röhrig , Christian Schütz , Samir Yahiaoui , Michael Zender
IPC分类号： A61K31/4439 , C07D401/12 , C07D401/14 , C07D471/04 , C07D403/12 , C07D417/12 , C07D417/14 , C07D413/12 , C07D405/14 , A61P31/04 , A61K31/444 , A61K31/506 , A61K45/06
摘要： The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
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公开(公告)号：US11883387B2
公开(公告)日：2024-01-30
申请号：US17257804
申请日：2019-07-03
发明人： Ahmed S. A. Ahmed , Martin Empting , Mostafa Hamed , Rolf W. Hartmann , Jörg Haupenthal , Thomas Hesterkamp , Ahmed A. M. Kamal , Christine K. Maurer , Teresa Röhrig , Christian Schütz , Samir Yahiaoui , Michael Zender
IPC分类号： A61K31/4439 , A61P31/04 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , A61P31/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
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