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公开(公告)号：US20120229791A1
公开(公告)日：2012-09-13
申请号：US13498062
申请日：2010-09-17
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/006 , G02B21/0064 , G02B21/0076 , G02B21/367 , G02B26/0891
摘要： A microscope including an illumination device providing a light sheet illuminating a sample region, said sheet having a planar extension along an illumination axis of an illumination beam path and a transverse axis lying normal to the illumination axis. A detection device detects light emitted from the sample region on a detection axis the illumination axis and detection axis as well as the transverse axis and the detection axis being oriented relative each other at an angle unequal zero. The detection device has a detection lens system arranged in the detection beam path and splitting means for splitting the detection beam path into two beam sub-paths. A dichroic beam splitter in the infinity region of the surface detectors is about 3 mm thick. Wobble plate(s) disposed orthogonal to each other relative to the detection axis arranged in one of the two beam sub-paths so measured values can be automatically superimposed.
摘要翻译： 一种显微镜，包括提供照射样品区域的光片的照明装置，所述片材沿着照明光束路径的照明轴线和垂直于照明轴线的横轴线具有平面延伸。 检测装置检测在检测轴上从样本区域发出的光，照明轴和检测轴以及横轴和检测轴相对于彼此以不等于零的角度取向。 检测装置具有设置在检测光束路径中的检测透镜系统和用于将检测光束路径分割成两个光束子路径的分离装置。 表面检测器的无限区域中的二向色分束器约为3mm厚。 摇摆板相对于布置在两个光束子路径之一中的检测轴线彼此正交配置，因此可以自动叠加测量值。
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公开(公告)号：US09239454B2
公开(公告)日：2016-01-19
申请号：US13498062
申请日：2010-09-17
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/006 , G02B21/0064 , G02B21/0076 , G02B21/367 , G02B26/0891
摘要： A microscope including an illumination device providing a light sheet illuminating a sample region, said sheet having a planar extension along an illumination axis of an illumination beam path and a transverse axis lying normal to the illumination axis. A detection device detects light emitted from the sample region on a detection axis the illumination axis and detection axis as well as the transverse axis and the detection axis being oriented relative each other at an angle unequal zero. The detection device has a detection lens system arranged in the detection beam path and splitting means for splitting the detection beam path into two beam sub-paths. A dichroic beam splitter in the infinity region of the surface detectors is about 3 mm thick. Wobble plate(s) disposed orthogonal to each other relative to the detection axis arranged in one of the two beam sub-paths so measured values can be automatically superimposed.
摘要翻译： 一种显微镜，包括提供照射样品区域的光片的照明装置，所述片材沿着照明光束路径的照明轴线和垂直于照明轴线的横轴线具有平面延伸。 检测装置检测在检测轴上从样本区域发出的光，照明轴和检测轴以及横轴和检测轴相对于彼此以不等于零的角度取向。 检测装置具有设置在检测光束路径中的检测透镜系统和用于将检测光束路径分割成两个光束子路径的分离装置。 表面检测器的无限区域中的二向色分束器约为3mm厚。 摇摆板相对于布置在两个光束子路径之一中的检测轴线彼此正交配置，因此可以自动叠加测量值。
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公开(公告)号：US20120281264A1
公开(公告)日：2012-11-08
申请号：US13498095
申请日：2010-09-17
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B26/08 , G02B27/0911
摘要： A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.
摘要翻译： 显微镜系列包括照明装置，其沿着照明光束路径的照明轴线和垂直于照明轴线的横轴产生平面光片。 检测装置沿着检测光束路径的检测轴检测从样本区域发射的光。 照明和检测轴以及横轴和检测轴线以不等于零的角度相对定向。 光片发生器还产生旋转对称的光，并且包括用于沿横轴快速扫描样品区域的结构和控制。 照明装置包括具有第一散光活性光学元件的第二光片发生器，该光学元件具有用于产生静态光的至少一个散光透镜。 用于选择第一或第二光照片或两者的选择元件一起产生光线。
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公开(公告)号：US08848268B2
公开(公告)日：2014-09-30
申请号：US13498095
申请日：2010-09-17
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B26/08 , G02B27/0911
摘要： A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.
摘要翻译： 显微镜系列包括照明装置，其沿着照明光束路径的照明轴线和垂直于照明轴线的横轴产生平面光片。 检测装置沿着检测光束路径的检测轴检测从样本区域发射的光。 照明和检测轴以及横轴和检测轴线以不等于零的角度相对定向。 光片发生器还产生旋转对称的光，并且包括用于沿横轴快速扫描样品区域的结构和控制。 照明装置包括具有第一散光活性光学元件的第二光片发生器，该光学元件具有用于产生静态光的至少一个散光透镜。 用于选择第一或第二光照片或两者的选择元件一起产生光线。
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公开(公告)号：US07787179B2
公开(公告)日：2010-08-31
申请号：US11946232
申请日：2007-11-28
申请人： Helmut Lippert , Matthias Wald , Benno Radt
发明人： Helmut Lippert , Matthias Wald , Benno Radt
CPC分类号： G02B21/16 , G02B21/06 , G02B26/08 , G02B27/0911
摘要： The invention is directed to an optical arrangement with a light source for emitting a light bundle and with optical elements for transforming this light bundle into the shape of a light sheet, particularly suitable for illuminating individual planes of a three-dimensional specimen in selective plane illumination microscopy (SPIM). According to the invention, means are provided for varying the cross section of the light sheet, for varying the length of the light sheet and/or for influencing the direction in which individual beam components extending within the light sheet are directed to the specimen substance. This makes it possible to adapt the geometry of the light sheet to the illumination requirements for observing one and the same specimen plane with a plurality of different objectives and, if required, to reduce shadows occurring within the observed specimen plane as a result of the illumination.
摘要翻译： 本发明涉及一种光学装置，其具有用于发射光束的光源和用于将该光束变换为光片的形状的光学元件，特别适用于在选择性平面照明中照射三维样本的各个平面 显微镜（SPIM）。 根据本发明，提供了用于改变光片的横截面的装置，用于改变光片的长度和/或用于影响在光片内延伸的各个光束分量被引导到样本物质的方向。 这使得可以使光片的几何尺寸适应于用于观察具有多个不同物镜的同一样本平面的照明要求，并且如果需要，可以减少作为照明的结果在观察到的样本平面内发生的阴影 。
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公开(公告)号：US09110301B2
公开(公告)日：2015-08-18
申请号：US13497996
申请日：2010-09-17
CPC分类号： G02B21/241 , G02B21/002 , G02B21/06
摘要： A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region.
摘要翻译： 具有照明系统的一系列显微镜，其在照明光束路径的照明轴线和垂直于照明轴线的横向轴线上引导具有近似平面延伸的光线。 显微镜具有用于检测由样品区域发射的光的检测装置。 检测装置包括设置在检测光束路径中的检测透镜系统和与检测透镜系统的前透镜间隔开的光学检测元件，并且可独立调节。 光检测元件连续地改变检测图像场的大小和/或连续地移位P区域中的检测焦平面。
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公开(公告)号：US20090237765A1
公开(公告)日：2009-09-24
申请号：US11946232
申请日：2007-11-28
申请人： Helmut Lippert , Matthias Wald , Benno Radt
发明人： Helmut Lippert , Matthias Wald , Benno Radt
CPC分类号： G02B21/16 , G02B21/06 , G02B26/08 , G02B27/0911
摘要： The invention is directed to an optical arrangement with a light source for emitting a light bundle and with optical elements for transforming this light bundle into the shape of a light sheet, particularly suitable for illuminating individual planes of a three-dimensional specimen in selective plane illumination microscopy (SPIM). According to the invention, means are provided for varying the cross section of the light sheet, for varying the length of the light sheet and/or for influencing the direction in which individual beam components extending within the light sheet are directed to the specimen substance. This makes it possible to adapt the geometry of the light sheet to the illumination requirements for observing one and the same specimen plane with a plurality of different objectives and, if required, to reduce shadows occurring within the observed specimen plane as a result of the illumination.
摘要翻译： 本发明涉及一种光学装置，其具有用于发射光束的光源和用于将该光束变换为光片的形状的光学元件，特别适用于在选择性平面照明中照射三维样本的各个平面 显微镜（SPIM）。 根据本发明，提供了用于改变光片的横截面的装置，用于改变光片的长度和/或用于影响在光片内延伸的各个光束分量被引导到样本物质的方向。 这使得可以使光片的几何尺寸适应于用于观察具有多个不同物镜的同一样本平面的照明要求，并且如果需要，可以减少作为照明的结果在观察到的样本平面内发生的阴影 。
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公开(公告)号：US20120200693A1
公开(公告)日：2012-08-09
申请号：US13497996
申请日：2010-09-17
IPC分类号： H04N7/18
CPC分类号： G02B21/241 , G02B21/002 , G02B21/06
摘要： A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region.
摘要翻译： 具有照明系统的一系列显微镜，其在照明光束路径的照明轴线和垂直于照明轴线的横向轴线上引导具有近似平面延伸的光线。 显微镜具有用于检测由样品区域发射的光的检测装置。 检测装置包括设置在检测光束路径中的检测透镜系统和与检测透镜系统的前透镜间隔开的光学检测元件，并且可独立调节。 光检测元件连续地改变检测图像场的大小和/或连续地移位P区域中的检测焦平面。
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公开(公告)号：US08228499B2
公开(公告)日：2012-07-24
申请号：US12682234
申请日：2008-09-18
CPC分类号： G02B21/34
摘要： The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices are proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation.
摘要翻译： 本发明涉及将显影装置的样本空间中至少一个优选生物样本定位的方法以及用于实施这些方法的装置。 提出了相对于检测对象的光轴的试样的取向可以反复改变的方法和装置，并且在这样做的同时，保持试样，使得从每个检测方向确保了样本的基本无阻碍的视图。 在不同的结构变型中，试样通过粘合力或流动介质保持在支撑装置上，通过毛细管作用将样品保持在毛细管开口处，或者至少一个样品嵌入透明凝胶体中， 凝胶体通过可旋转保持装置固定在样本空间中，并且通过使保持装置旋转给定的旋转角度来改变检测方向。
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公开(公告)号：US08042782B2
公开(公告)日：2011-10-25
申请号：US12034374
申请日：2008-02-20
申请人： Helmut Lippert , Peter Reichert
发明人： Helmut Lippert , Peter Reichert
IPC分类号： A47H1/10
CPC分类号： H04R1/026
摘要： Loudspeaker wall holder and method of mounting a loudspeaker box. The loudspeaker wall holder includes a base mountable on a wall surface, an arm coupled to the base, and a holder comprising a clamping device. The holder is mounted on the arm and is structured and arranged to receive a portion of a loudspeaker box. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
摘要翻译： 扬声器墙架和安装扬声器盒的方法。 扬声器壁保持器包括可安装在壁表面上的基座，联接到基座的臂和包括夹紧装置的保持器。 保持器安装在臂上并且被构造和布置成接收扬声器箱的一部分。 本摘要既不旨在限定本说明书中公开的发明，也不旨在以任何方式限制本发明的范围。
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