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公开(公告)号:US06716156B2
公开(公告)日:2004-04-06
申请号:US10066918
申请日:2002-02-04
申请人: Helmut Menuhr , Eberhard Fritz , Mark Shilton
发明人: Helmut Menuhr , Eberhard Fritz , Mark Shilton
IPC分类号: A61N500
CPC分类号: A61N5/1027 , A61N2005/1024
摘要: A radioactive or activatable seed for use in brachytherapy, and a method for producing the seed, the seed comprising a closed and self-supported casing consisting of (a) a radioactive or activatable metallic material selected from the group consisting of a metal, an alloy and a metal composite or mixtures thereof, optionally in combination with (b) a non-radioactive, non-activatable metallic material; wherein (a) comprises a radioactive nuclide selected from the group consisting of Pd-103, Tm-170, Sr-90, Y-90, Yb-169, P-32, Ge-71, Se-75, Cl-36, Ta-182, Tl-204, Re-188, W-188, Ce-144, Pr-144, Sn-123, Ru-106, Rh-106 and mixtures thereof, and/or an activatable precursor nuclide thereof selected from the group consisting of Pd-102, Rh-103, Tm-169, Y-89, Yb-168, P-31, Ge-70, Se-74, Cl-35, Ta-181, Tl-203, W-186, Sn-122 and mixtures thereof, excluding metallic Pd with natural abundance of Pd-102.
摘要翻译: 一种用于近距离放射治疗的放射性或可激活的种子,以及一种用于生产种子的方法,该种子包括一个封闭的和自支撑的壳体,该壳体由(a)放射性或可激活的金属材料组成,该金属材料选自金属,合金 和金属复合材料或其混合物,任选地与(b)非放射性不可激活的金属材料组合; 其中(a)包括选自Pd-103,Tm-170,Sr-90,Y-90,Yb-169,P-32,Ge-71,Se-75,Cl-36, Ta-182,Tl-204,Re-188,W-188,Ce-144,Pr-144,Sn-123,Ru-106,Rh-106及其混合物,和/或其可活化的前体核素, 由Pd-102,Rh-103,Tm-169,Y-89,Yb-168,P-31,Ge-70,Se-74,Cl-35,Ta-181,Tl-203,W-186组成的组 ,Sn-122及其混合物,不包括Pd-102天然丰度的金属Pd。