公开(公告)号：US06818908B2

公开(公告)日：2004-11-16

申请号：US10478531

申请日：2003-11-20

申请人： Tetsuya Makimura

发明人： Tetsuya Makimura

IPC分类号： A61N500

CPC分类号： C03C23/00 ,  B23K26/0661 ,  B23K26/60 ,  G03F7/203 ,  G03F7/70375 ,  G03F7/70383

摘要： Discloses a photo machining apparatus and a photo-fabrication method to perform two-dimensional or three-dimensional fabrication of an inorganic transparent material with a precision of 10 nm. Soft X-ray (2) emitted from a soft X-ray source (1) is focally applied by an optical system 3 comprising a combination of a concave mirror and convex mirrors onto an inorganic transparent material (4) in a predetermined pattern to generate new absorption in a irradiated region of the inorganic transparent material, which is then irradiated with a machining laser beam (5) so that a visible or ultraviolet machining laser beam (5) having a high energy density is absorbed exclusively in the part of the patterned inorganic transparent material (4) to fabricate the inorganic transparent material (4).

摘要翻译： 公开了一种以10nm的精度执行无机透明材料的二维或三维制造的光加工装置和光制造方法。 从软X射线源（1）发射的软X射线（2）通过包括凹面镜和凸面镜的组合的光学系统3以预定图案被物理地施加到无机透明材料（4）上，以产生 在无机透明材料的照射区域中的新吸收，然后用机械激光束（5）照射，使得具有高能量密度的可见或紫外线加工激光束（5）仅被吸收在图案化部分 无机透明材料（4），以制造无机透明材料（4）。

公开(公告)号：US06805701B1

公开(公告)日：2004-10-19

申请号：US09362231

申请日：1999-07-28

申请人： Marta Cortes

发明人： Marta Cortes

IPC分类号： A61N500

CPC分类号： A61N5/06 ,  A61N2005/067

摘要： The present invention generally relates to a method for the site specific enhancement of cytokine release (through chemotaxis) namely beta chemokines and enhance healing via an enhanced overall immune response. The site specific enhancement of cytokine release is achieved by initiating an inflamatory response by laser therapy.

摘要翻译： 本发明一般涉及通过增强的整体免疫应答增强细胞因子释放（通过趋化性）即β趋化因子并增强愈合的位点特异性增强的方法。 通过激光治疗引发炎症反应来实现细胞因子释放的位点特异性增强。

公开(公告)号：US06800866B2

公开(公告)日：2004-10-05

申请号：US10101214

申请日：2002-03-20

申请人： Kensuke Amemiya ,  Kazuo Hiramoto ,  Masanobu Tanaka ,  Shigemitsu Hara

发明人： Kensuke Amemiya ,  Kazuo Hiramoto ,  Masanobu Tanaka ,  Shigemitsu Hara

IPC分类号： A61N500

CPC分类号： H05H13/04 ,  G21K5/04 ,  H05H7/00

摘要： To provide an accelerator system having a wide ion beam current control range, being capable of operating with low power consumption and a long maintenance interval and being capable of preventing unnecessarily large dose of the ion beam for irradiation from erroneously being supplied to the downstream side of the system. In an accelerator system designed to treat the patient with irradiation of a high-energy ion beam accelerated by a post-accelerator 4 comprising a synchrotron in irradiation rooms 6 to 8, a value of ion beam current to be supplied to the post-accelerator 4 is controlled by a pre-accelerator comprising an ion source 10, quadrupole electromagnet 15, radio frequency quadrupole accelerator 17 and a drift tube type accelerator 19. The accelerator system featuring low power consumption, a long maintenance interval and high reliability can be made available.

摘要翻译： 为了提供具有宽的离子束电流控制范围的加速器系统，能够以低功耗和长维护间隔进行操作，并且能够防止不必要的大剂量的离子束被照射错误地供给到下游侧 该系统设计用于通过在包括照射室6至8中的同步加速器的后加速器4加速的高能离子束的照射来治疗患者的加速器系统中，提供给柱的离子束电流的值 加速器4由包括离子源10，四极电磁体15，射频四极加速器17和漂移管型加速器19的预加速器控制。具有低功耗，长维护间隔和高可靠性的加速器系统可以是 提供。

公开(公告)号：US06800861B2

公开(公告)日：2004-10-05

申请号：US10140666

申请日：2002-05-08

申请人： Josephus J. M. Braat

发明人： Josephus J. M. Braat

IPC分类号： A61N500

CPC分类号： G03F7/70233 ,  G02B17/0657 ,  G03F7/70275 ,  G03F7/70358

摘要： A mirror projection system for use in a step-and-scan lithographic projection apparatus, in which a mask pattern (15) is repetitively scan-imaged on a number of areas of a substrate (20) by means of a beam (b) of EUV radiation having a cross-section shaped as a segment of a ring, has six imaging mirrors (5-10). The design is such that no intermediate image is formed and the system has a negative magnification. When using this projection system in a scanning apparatus, the mask and the substrate move in opposite directions during scanning, which is advantageous from a mechanical point of view.

摘要翻译： 一种用于步进和扫描光刻投影装置的镜面投影系统，其中通过光束（b）在掩模图案（15）的多个区域上重复地扫描成像在基板（20）的多个区域上， 具有成形为环的段的横截面的EUV辐射具有六个成像镜（5-10）。 该设计使得不形成中间图像，并且系统具有负放大率。 当在扫描装置中使用该投影系统时，掩模和基板在扫描期间沿相反的方向移动，这从机械的观点来看是有利的。

公开(公告)号：US06761680B2

公开(公告)日：2004-07-13

申请号：US10162548

申请日：2002-06-04

申请人： Richard A. Terwilliger ,  Gary A. Lamoureux

发明人： Richard A. Terwilliger ,  Gary A. Lamoureux

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024 ,  B29C47/0023 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08

摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.

摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和径向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 还提供了用于制造自动制作种子股的间质放射线种子股的系统。 递送系统和方法基于处方进一步定制成员。

公开(公告)号：US06749553B2

公开(公告)日：2004-06-15

申请号：US09858816

申请日：2001-05-16

申请人： Richard A. Brauckman ,  Jack C. White ,  Glenn A. Dill ,  Michael R. Moody

发明人： Richard A. Brauckman ,  Jack C. White ,  Glenn A. Dill ,  Michael R. Moody

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1025

摘要： Radiation delivery devices useful in brachytherapy which employ radioactive palladium-103 as the radiation source material are disclosed. Certain embodiments of the disclosed radiation delivery devices have the advantages that they can be fabricated with the desired specific activity, that the self-shielding effects of the devices are minimized, that the radioactive source material is bonded to a substrate in a manner which substantially prevents it from becoming detached, and that a variety of customizable radiation delivery devices can be made using the concepts of the invention. Also disclosed are processes for bonding radiation source material to various substrates using electroless plating, chemical vapor deposition and polymer matrices. These processes have the advantage that they can be applied to bond the radiation source material to a wide variety of substrates including different substrate materials and differently shaped substrates, thereby providing the ability to tailor the radiation delivery devices to the specific requirements of a particular brachytherapy treatment.

摘要翻译： 公开了使用放射性钯-103作为辐射源材料的用于近距离放射治疗的辐射递送装置。 所公开的辐射递送装置的某些实施例具有这样的优点：它们可以以期望的比活度制造，使得装置的自屏蔽作用最小化，放射源材料以基本上防止的方式结合到基底 它变得分离，并且可以使用本发明的概念制造各种可定制的辐射递送装置。 还公开了使用化学镀，化学气相沉积和聚合物基质将辐射源材料粘合到各种基底的方法。 这些方法具有这样的优点：它们可以用于将辐射源材料粘合到包括不同基底材料和不同形状的基底的各种基底上，从而提供根据特定近距离放射疗法治疗的具体要求来定制辐射递送装置的能力 。

公开(公告)号：US06716156B2

公开(公告)日：2004-04-06

申请号：US10066918

申请日：2002-02-04

申请人： Helmut Menuhr ,  Eberhard Fritz ,  Mark Shilton

发明人： Helmut Menuhr ,  Eberhard Fritz ,  Mark Shilton

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1024

摘要： A radioactive or activatable seed for use in brachytherapy, and a method for producing the seed, the seed comprising a closed and self-supported casing consisting of (a) a radioactive or activatable metallic material selected from the group consisting of a metal, an alloy and a metal composite or mixtures thereof, optionally in combination with (b) a non-radioactive, non-activatable metallic material; wherein (a) comprises a radioactive nuclide selected from the group consisting of Pd-103, Tm-170, Sr-90, Y-90, Yb-169, P-32, Ge-71, Se-75, Cl-36, Ta-182, Tl-204, Re-188, W-188, Ce-144, Pr-144, Sn-123, Ru-106, Rh-106 and mixtures thereof, and/or an activatable precursor nuclide thereof selected from the group consisting of Pd-102, Rh-103, Tm-169, Y-89, Yb-168, P-31, Ge-70, Se-74, Cl-35, Ta-181, Tl-203, W-186, Sn-122 and mixtures thereof, excluding metallic Pd with natural abundance of Pd-102.

摘要翻译： 一种用于近距离放射治疗的放射性或可激活的种子，以及一种用于生产种子的方法，该种子包括一个封闭的和自支撑的壳体，该壳体由（a）放射性或可激活的金属材料组成，该金属材料选自金属，合金 和金属复合材料或其混合物，任选地与（b）非放射性不可激活的金属材料组合; 其中（a）包括选自Pd-103，Tm-170，Sr-90，Y-90，Yb-169，P-32，Ge-71，Se-75，Cl-36， Ta-182，Tl-204，Re-188，W-188，Ce-144，Pr-144，Sn-123，Ru-106，Rh-106及其混合物，和/或其可活化的前体核素， 由Pd-102，Rh-103，Tm-169，Y-89，Yb-168，P-31，Ge-70，Se-74，Cl-35，Ta-181，Tl-203，W-186组成的组 ，Sn-122及其混合物，不包括Pd-102天然丰度的金属Pd。

公开(公告)号：US06709381B2

公开(公告)日：2004-03-23

申请号：US10160881

申请日：2002-05-31

申请人： John J. Munro, III

发明人： John J. Munro, III

IPC分类号： A61N500

CPC分类号： A61N5/1001 ,  A61N5/1027 ,  A61N2005/1011 ,  A61N2005/1023

摘要： A system for brachytherapy is provided. The system includes an implantation device having a tubular member, a radioactive source within the member, and a socket at opposing ends of the tubular member. A plurality of implantation devices may be joined into an assembly by use of a spacer positioned within the sockets of adjoining devices. The device may be deployed at an implantation site by use of a delivery mechanism, such as needle. The presence of the tubular members and spacers minimizes movement of the radioactive source subsequent to deployment, so as not to alter dose distribution for subsequent irradiation.

摘要翻译： 提供一种近距离放射治疗系统。 该系统包括具有管状构件，构件内的放射源和在管状构件的相对端处的插座的植入装置。 多个植入装置可以通过使用位于相邻装置的插座内的间隔件连接到组件中。 该装置可以通过使用诸如针的递送机构来部署在植入位置。 管状构件和隔离物的存在使放射源在展开后的移动最小化，以便不改变随后照射的剂量分布。

公开(公告)号：US06699171B2

公开(公告)日：2004-03-02

申请号：US10073078

申请日：2002-02-12

申请人： Michael B. Harmon

发明人： Michael B. Harmon

IPC分类号： A61N500

CPC分类号： A61N5/1016

摘要： A modified Fletcher-Suit tandem tube applicator includes a balloon which can be inflated to both positionally secure the applicator within the vaginal canal and to distend the confronting vaginal wall thereby increasing the distance of such tissue from the radioactive source contained in the tandem tube of applicator and correspondingly reducing radiation damage to nearby tissues and organs such as the rectum and bladder.

摘要翻译： 改进的Fletcher-Suit串联管施放器包括可膨胀的气囊，以将施放器位于阴道内的位置上固定，并使相应的阴道壁膨胀，从而增加这种组织与包含在施放器串联管中的放射源的距离 并相应减少对附近组织和器官（如直肠和膀胱）的辐射损伤。

公开(公告)号：US06695760B1

公开(公告)日：2004-02-24

申请号：US10269555

申请日：2002-10-11

申请人： Rance A. Winkler ,  Timothy J. Patrick ,  Carribeth B. Ramey

发明人： Rance A. Winkler ,  Timothy J. Patrick ,  Carribeth B. Ramey

IPC分类号： A61N500

CPC分类号： A61F2/446 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30858 ,  A61F2002/4475 ,  A61M25/10 ,  A61M29/02 ,  A61M2210/1003 ,  A61N5/1027 ,  A61N2005/1005 ,  A61N2005/1021

摘要： A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.