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公开(公告)号：US20150306032A1
公开(公告)日：2015-10-29
申请号：US14793233
申请日：2015-07-07
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射治疗诱发呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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公开(公告)号：US08729094B2
公开(公告)日：2014-05-20
申请号：US13902132
申请日：2013-05-24
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A61K47/00
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射治疗诱发呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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公开(公告)号：US09457021B1
公开(公告)日：2016-10-04
申请号：US15190019
申请日：2016-06-22
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US09125905B2
公开(公告)日：2015-09-08
申请号：US14597489
申请日：2015-01-15
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A61K31/47 , A61K47/26 , A61K31/473 , B65B55/02 , B65B7/16
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射疗法诱导呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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公开(公告)号：US20150141454A1
公开(公告)日：2015-05-21
申请号：US14597489
申请日：2015-01-15
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A61K31/473 , B65B7/16 , B65B55/02
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20180193262A1
公开(公告)日：2018-07-12
申请号：US15708440
申请日：2017-09-19
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee , Carmine Panuccio
IPC分类号： A61K9/08 , A61K47/10 , B65B7/16 , B65B55/02 , A61K9/00 , A61K47/26 , A61K47/00 , A61K31/473 , A61K47/12 , A61K47/18 , A61K47/02
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20160317440A1
公开(公告)日：2016-11-03
申请号：US15209995
申请日：2016-07-14
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US09439854B2
公开(公告)日：2016-09-13
申请号：US14793233
申请日：2015-07-07
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A61K31/47 , A61K47/26 , A61K31/473 , A61K9/08 , A61K47/18 , A61K47/12 , A61K47/00 , A61K47/02 , A61K9/00 , B65B7/16 , B65B55/02 , A61K47/10
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20170042807A1
公开(公告)日：2017-02-16
申请号：US15240485
申请日：2016-08-18
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A61K9/08 , A61K47/18 , A61K47/26 , A61K31/473
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射治疗诱发呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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10.发明申请DOSAGE FORMS OF PALONOSETRON HYDROCHLORIDE HAVING IMPROVED STABILITY AND BIOAVAILABILITY 审中-公开具有改善稳定性和生物利用度的PALONOSETRON HYDROCHLIDE的剂型公开(公告)号：US20170035748A1
公开(公告)日：2017-02-09
申请号：US15298630
申请日：2016-10-20
发明人： Daniele Bonadeo , Giorgio Calderari
IPC分类号： A61K31/473 , A61K9/48 , A61K9/00
CPC分类号： A61K31/473 , A61K9/0053 , A61K9/4825 , A61K9/4858
摘要： Provided are solid oral dosage forms of palonosetron hydrochloride, methods of using the dosage forms to treat emesis, and methods of making the dosage forms. The dosage forms have improved stability and bioavailability, and are preferably in the form of liquid filled capsules.
摘要翻译： 提供了盐酸帕洛诺司琼的固体口服剂型，使用剂型治疗呕吐的方法，以及制备剂型的方法。 剂型具有改善的稳定性和生物利用度，并且优选为液体填充胶囊的形式。
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