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公开(公告)号：US12121562B2
公开(公告)日：2024-10-22
申请号：US18067940
申请日：2022-12-19
申请人： SANOFI
发明人： Gary J. Nabel , Chih-Jen Wei , Laura Nguyen , Kurt Swanson , Te-Hui Chou
IPC分类号： A61K39/245 , A61K38/16 , A61K39/12 , A61K47/00 , C07K14/05
CPC分类号： A61K38/162 , A61K47/00 , C07K14/05 , C07K2319/00
摘要： This disclosure relates to antigenic EBV polypeptides and their use in eliciting antibodies against EBV. Also disclosed are antigenic polypeptides comprising an EBV polypeptide and a ferritin protein.
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公开(公告)号：US20240207365A1
公开(公告)日：2024-06-27
申请号：US18598577
申请日：2024-03-07
IPC分类号： A61K38/26 , A61K9/00 , A61K9/08 , A61K38/00 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/26 , A61M5/142 , A61M5/32
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/08 , A61K38/00 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K47/20 , A61K47/26 , A61M5/142 , A61M5/32
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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公开(公告)号：US20240041984A1
公开(公告)日：2024-02-08
申请号：US18180002
申请日：2023-03-07
IPC分类号： A61K38/26 , A61M5/142 , A61K47/12 , A61K9/08 , A61K47/18 , A61M5/32 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/20 , A61K47/26 , A61K38/00 , A61K47/00
CPC分类号： A61K38/26 , A61M5/142 , A61K47/12 , A61K9/08 , A61K47/186 , A61K47/183 , A61M5/32 , A61K9/0019 , A61K47/02 , A61K47/10 , A61K47/20 , A61K47/26 , A61K38/00 , A61K47/00
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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4.发明公开公开(公告)号：US20240016796A1
公开(公告)日：2024-01-18
申请号：US18372968
申请日：2023-09-26
发明人： Zhenhua Huang , Xiaocui Guo
IPC分类号： A61K31/4745 , A61K47/10 , A61K9/00 , A61K47/20 , A61K47/26 , A61K47/32 , A61P13/12 , A61K47/18 , A61K47/00
CPC分类号： A61K31/4745 , A61K47/10 , A61K9/0053 , A61K47/20 , A61K47/26 , A61K47/32 , A61P13/12 , A61K47/186 , A61K9/00 , A61K47/00 , A61K45/06
摘要： Provided are a pharmaceutical composition comprising a mineralocorticoid receptor antagonist and use thereof. When the pharmaceutical composition is orally administered to a patient having chronic kidney disease in need thereof, the effective and safe AUC ranges from 188 ng*h/mL to 3173 ng*h/mL, with bioavailability of 50% or more in mammals. When the pharmaceutical composition is orally administered at a daily dose of 0.1 to 1.0 mg to treat chronic kidney disease, the AUC is controlled at a safe and effective level.
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公开(公告)号：US20230147683A1
公开(公告)日：2023-05-11
申请号：US17995079
申请日：2021-03-26
发明人： Morten SOMMER , Rasmus TOFT-KEHLER , Anne Katrine TOFT-KEHLER , Mads JELLINGSOE , Philippe ANDRES
IPC分类号： A61K31/609 , A61K47/10 , A61K47/22 , A61K31/167 , A61K9/00 , A61P31/14 , A61K47/32 , A61K47/40 , A61K47/20 , A61K47/00 , A61K9/08
CPC分类号： A61K31/609 , A61K47/10 , A61K47/22 , A61K31/167 , A61K9/0078 , A61P31/14 , A61K47/32 , A61K47/40 , A61K47/20 , A61K47/00 , A61K9/08 , A61K9/0043
摘要： Inhalable compositions comprising niclosamide, or a pharmaceutically acceptable salt thereof, and polyethylene glycol; aerosols of the compositions; and the pulmonary administrations for use in the treatment of viral infections, for example respiratory viral infections.
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公开(公告)号：US20180303944A1
公开(公告)日：2018-10-25
申请号：US15984261
申请日：2018-05-18
发明人： Oleh Taratula , Canan Schumann , Olena Taratula , Adam W.G. Alani
IPC分类号： A61K47/34 , A61K48/00 , A61K31/7105 , C08L77/04 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K31/7105 , A61K38/16 , A61K38/24 , A61K45/06 , A61K47/00 , A61K48/0058 , A61P21/00 , C07K14/473 , C08L77/04 , C08L2203/02
摘要： mRNA polymer complexes and drug delivery systems are disclosed herein that include a cationic polymer electrostatically complexed to an mRNA molecule that encodes a desired protein. Also disclosed herein are methods of treating as well as methods of slowing the loss of, increasing, and/or maintaining lean muscle mass in a subject, such as using mRNA polymer complexes and drug delivery systems.
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公开(公告)号：US20180104353A1
公开(公告)日：2018-04-19
申请号：US15844232
申请日：2017-12-15
IPC分类号： C07F15/00 , A61K47/00 , A61K31/282
CPC分类号： A61K47/60 , A61K31/282 , A61K47/00 , A61K47/50 , A61K47/58 , A61K47/64 , A61K47/641 , A61K47/68 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07F15/0086
摘要： The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, with in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O—*Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.
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公开(公告)号：US09941034B2
公开(公告)日：2018-04-10
申请号：US15151165
申请日：2016-05-10
发明人： Barbara Young
IPC分类号： H01B13/02 , B05D1/02 , H01B13/06 , H01B13/00 , A61K47/00 , D04H1/00 , D01D5/00 , A61K9/00 , G03G15/00 , A61K38/00
CPC分类号： H01B13/0271 , A61K9/00 , A61K38/00 , A61K47/00 , B05D1/02 , B29D1/00 , D01D5/00 , D04H1/00 , G03G15/00 , H01B13/0003 , H01B13/06
摘要： A direct write dispensing nozzle assembly and method of forming traces and twisted pairs via direct write dispensing. The method includes dispensing conductive material via an inner nozzle so as to form a conductive core. Non-conductive material may be dispensed via a peripheral nozzle surrounding the inner nozzle so as to form a non-conductive casing surrounding the conductive core. The first conductive core and the non-conductive casing may then be deposited on a substrate or other surface. The trace may be positioned on the substrate such that the non-conductive casing contacts a previously deposited trace. An additional conductive core may be dispensed within the non-conductive casing and the direct write dispensing nozzle assembly may be rotated so as to form a twisted pair.
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9.发明申请公开(公告)号：US20180049978A1
公开(公告)日：2018-02-22
申请号：US15797641
申请日：2017-10-30
发明人： Heather N. Mendenhall , Richard W. Hartel , JoAnne Robbins , Jacqueline A. Hind , Zata M. Vickers
CPC分类号： A61K9/0053 , A23L2/38 , A23L33/10 , A23L33/30 , A23L33/40 , A61B5/038 , A61B5/4205 , A61K9/0056 , A61K9/0095 , A61K47/00 , A61K49/0404
摘要： An edible composition of matter having an apparent viscosity of from about 150 cP to about 2000 cP at about 30 s−1; a yield stress of from 0 Pa to about 20 Pa at 1 s−1; and a flow index of from about 0.2 to about 0.6. The composition may include an imaging agent. The compositions are useful for providing sustenance to dysphagic subjects and for evalualuating dysphagia.
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公开(公告)号：US09884123B2
公开(公告)日：2018-02-06
申请号：US14370524
申请日：2013-01-03
CPC分类号： A61K47/60 , A61K31/282 , A61K47/00 , A61K47/50 , A61K47/58 , A61K47/64 , A61K47/641 , A61K47/68 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07F15/0086
摘要： The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, which in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O→Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.
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