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公开(公告)号：US07786097B2
公开(公告)日：2010-08-31
申请号：US12506825
申请日：2009-07-21
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080188443A1
公开(公告)日：2008-08-07
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07D213/72 , A61K31/44 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/28 , A61P29/00 , A61P11/06 , C07K14/72 , C07F9/09
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US07598231B2
公开(公告)日：2009-10-06
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07F9/58
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20090281148A1
公开(公告)日：2009-11-12
申请号：US12506825
申请日：2009-07-21
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Ronald Keith Webber
IPC分类号： A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20100286214A1
公开(公告)日：2010-11-11
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20120088802A9
公开(公告)日：2012-04-12
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080312294A1
公开(公告)日：2008-12-18
申请号：US12023323
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/44 , C07D213/72 , C07K14/705 , A61P29/00 , A61P25/28
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US07547714B2
公开(公告)日：2009-06-16
申请号：US12023323
申请日：2008-01-31
IPC分类号： A61K31/44 , C07D213/72
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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