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公开(公告)号：US07598231B2
公开(公告)日：2009-10-06
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07F9/58
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US07786097B2
公开(公告)日：2010-08-31
申请号：US12506825
申请日：2009-07-21
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080188443A1
公开(公告)日：2008-08-07
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07D213/72 , A61K31/44 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/28 , A61P29/00 , A61P11/06 , C07K14/72 , C07F9/09
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20100286214A1
公开(公告)日：2010-11-11
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20120088802A9
公开(公告)日：2012-04-12
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080312294A1
公开(公告)日：2008-12-18
申请号：US12023323
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/44 , C07D213/72 , C07K14/705 , A61P29/00 , A61P25/28
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US08158660B2
公开(公告)日：2012-04-17
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao Cheng , Xiao Hu , Kevin D. Jerome , Mark G. Obukowicz , Lisa Maria Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao Cheng , Xiao Hu , Kevin D. Jerome , Mark G. Obukowicz , Lisa Maria Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US08445520B2
公开(公告)日：2013-05-21
申请号：US13333104
申请日：2011-12-21
申请人： Hengmiao Cheng , Xiao Hu , Kevin D. Jerome , Mark G. Obukowicz , Lisa Maria Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao Cheng , Xiao Hu , Kevin D. Jerome , Mark G. Obukowicz , Lisa Maria Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/44 , C07D211/68 , C12N5/00
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
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公开(公告)号：US07067540B2
公开(公告)日：2006-06-27
申请号：US10367987
申请日：2003-02-14
申请人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
发明人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
IPC分类号： A61K31/44 , C07D213/02 , C07D401/02
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译： 公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。
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公开(公告)号：US07629363B2
公开(公告)日：2009-12-08
申请号：US11226556
申请日：2005-09-14
申请人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
发明人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
IPC分类号： A61K31/44 , C07D211/02
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译： 公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3 / R 4和R 5在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。
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