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1.发明申请USE OF FLAT PANEL MICROCHANNEL PHOTOMULTIPLIERS IN SAMPLING CALORIMETERS WITH TIMING 有权平板微电子照相机在采样计时器中的使用公开(公告)号：US20110220802A1
公开(公告)日：2011-09-15
申请号：US13044442
申请日：2011-03-09
申请人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang
发明人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang
CPC分类号： G01T1/208 , G01T1/2928 , G01T1/2985 , G01T1/363
摘要： Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of sampling calorimeters with, for example, enhanced capability to measure local energy deposition, depth-of-interaction, time-of-flight, and/or directionality of showers. In certain embodiments, sub-nanosecond timing resolution supplies correlated position and time measurements over large areas. The use of thin flat-panel viewing radiators on both sides of a radiation-creating medium allows simultaneous measurement of Cherenkov and scintillation radiation in each layer of the calorimeter. The detectors may be used in a variety of applications including, for example, medical imaging, security, and particle and nuclear physics.
摘要翻译： 提供了基于微通道板的亚纳秒时间分辨率的大面积平板光电探测器。 大面积的平板光电探测器能够对采样量热仪进行经济建设，例如增强测量局部能量沉积，相互作用深度，飞行时间和/或淋浴方向性的能力。 在某些实施例中，亚纳秒定时分辨率在大面积上提供相关位置和时间测量。 在辐射产生介质的两侧使用薄的平板观察辐射器允许同时测量量热计的每层中的切伦科夫和闪烁辐射。 检测器可以用于各种应用，包括例如医学成像，安全性，粒子和核物理学。
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2.发明授权Use of flat panel microchannel photomultipliers in sampling calorimeters with timing 有权平板微通道光电倍增器在采样量热仪中的使用公开(公告)号：US08604440B2
公开(公告)日：2013-12-10
申请号：US13044442
申请日：2011-03-09
申请人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang , Jeffrey W. Elam , Anil U. Mane
发明人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang , Jeffrey W. Elam , Anil U. Mane
IPC分类号： G01T1/164
CPC分类号： G01T1/208 , G01T1/2928 , G01T1/2985 , G01T1/363
摘要： Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of sampling calorimeters with, for example, enhanced capability to measure local energy deposition, depth-of-interaction, time-of-flight, and/or directionality of showers. In certain embodiments, sub-nanosecond timing resolution supplies correlated position and time measurements over large areas. The use of thin flat-panel viewing radiators on both sides of a radiation-creating medium allows simultaneous measurement of Cherenkov and scintillation radiation in each layer of the calorimeter. The detectors may be used in a variety of applications including, for example, medical imaging, security, and particle and nuclear physics.
摘要翻译： 提供了基于微通道板的亚纳秒时间分辨率的大面积平板光电探测器。 大面积的平板光电探测器能够对采样量热仪进行经济建设，例如增强测量局部能量沉积，相互作用深度，飞行时间和/或淋浴方向性的能力。 在某些实施例中，亚纳秒定时分辨率在大面积上提供相关位置和时间测量。 在辐射产生介质的两侧使用薄的平板观察辐射器允许同时测量量热计的每层中的切伦科夫和闪烁辐射。 检测器可以用于各种应用，包括例如医学成像，安全性，粒子和核物理学。
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公开(公告)号：US07342232B2
公开(公告)日：2008-03-11
申请号：US11097153
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
IPC分类号： G01T1/164
CPC分类号： G01T1/17 , A61B6/037 , G01T1/1647 , G01T1/2985
摘要： A device and method used in the high resolution Positron Emission Tomography (PET) systems for digitizing radiation events for a scintillation camera and a data acquisition system. The device comprises a scintillation digitizer, including a plurality of comparators and amplifiers, two ADCs, and an analyzer for resolving the digital values of radiation events. The method comprises comparing a plurality of analog electric pulses generated upon radiation event detections with a reference voltage corresponding to an energy level of interest, amplifying all of the signals with two groups of coefficients, summing the two groups of amplified signals, digitizing the summed signals, and analyzing the digitized sums to determine digital values corresponding to a plurality of the radiation events.
摘要翻译： 用于数字化用于闪烁照相机和数据采集系统的辐射事件的高分辨率正电子发射断层扫描（PET）系统中的装置和方法。 该装置包括闪烁数字转换器，包括多个比较器和放大器，两个ADC和用于分辨辐射事件的数字值的分析器。 该方法包括将辐射事件检测所产生的多个模拟电脉冲与对应于感兴趣能级的参考电压进行比较，用两组系数放大所有信号，对两组放大信号求和，对相加的信号进行数字化 并且分析数字化和以确定对应于多个辐射事件的数字值。
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4.发明授权Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC 有权用于数字化伽马射线能量并表征峰值时间和衰减时间常数而不使用ADC的装置和方法公开(公告)号：US07199370B2
公开(公告)日：2007-04-03
申请号：US11097121
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A device and method used in high resolution positron emission tomography (PET) systems for digitizing gamma ray energy and characterizing peak time and decay time constant, models a voltage pulse generated upon a PET event detection as a fast linearly rising edge followed by a slower exponential decay. The model includes parameters of the voltage pulse that are relevant for PET event detection including a decay constant, a peak voltage value, and a peak time, which are determined from time interval measurements of the voltage pulse. The time interval measurements are made using comparators and counters in an exemplary electronic implementation.
摘要翻译： 在用于数字化伽马射线能量并表征峰值时间和衰减时间常数的高分辨率正电子发射断层摄影（PET）系统中使用的装置和方法，将在PET事件检测时产生的电压脉冲建模为快速线性上升沿，随后是较慢的指数 衰变。 该模型包括与包括衰减常数，峰值电压值和峰值时间相关的PET事件检测的电压脉冲的参数，其由电压脉冲的时间间隔测量确定。 在示例性电子实现中使用比较器和计数器进行时间间隔测量。
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公开(公告)号：US20060000979A1
公开(公告)日：2006-01-05
申请号：US11097153
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
IPC分类号： G01T1/164
CPC分类号： G01T1/17 , A61B6/037 , G01T1/1647 , G01T1/2985
摘要： A device and method used in the high resolution Positron Emission Tomography (PET) systems for digitizing radiation events for a scintillation camera and a data acquisition system. The device comprises a scintillation digitizer, including a plurality of comparators and amplifiers, two ADCs, and an analyzer for resolving the digital values of radiation events. The method comprises comparing a plurality of analog electric pulses generated upon radiation event detections with a reference voltage corresponding to an energy level of interest, amplifying all of the signals with two groups of coefficients, summing the two groups of amplified signals, digitizing the summed signals, and analyzing the digitized sums to determine digital values corresponding to a plurality of the radiation events.
摘要翻译： 用于数字化用于闪烁照相机和数据采集系统的辐射事件的高分辨率正电子发射断层扫描（PET）系统中的装置和方法。 该装置包括闪烁数字转换器，包括多个比较器和放大器，两个ADC和用于分辨辐射事件的数字值的分析器。 该方法包括将辐射事件检测所产生的多个模拟电脉冲与对应于感兴趣能级的参考电压进行比较，用两组系数放大所有信号，对两组放大信号求和，对相加的信号进行数字化 并且分析数字化和以确定对应于多个辐射事件的数字值。
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6.发明申请Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC 有权用于数字化伽马射线能量并表征峰值时间和衰减时间常数而不使用ADC的装置和方法公开(公告)号：US20050247879A1
公开(公告)日：2005-11-10
申请号：US11097121
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
CPC分类号： G01T1/2985 , A61B6/037
摘要： A device and method used in high resolution positron emission tomography (PET) systems for digitizing gamma ray energy and characterizing peak time and decay time constant, models a voltage pulse generated upon a PET event detection as a fast linearly rising edge followed by a slower exponential decay. The model includes parameters of the voltage pulse that are relevant for PET event detection including a decay constant, a peak voltage value, and a peak time, which are determined from time interval measurements of the voltage pulse. The time interval measurements are made using comparators and counters in an exemplary electronic implementation.
摘要翻译： 在用于数字化伽马射线能量并表征峰值时间和衰减时间常数的高分辨率正电子发射断层摄影（PET）系统中使用的装置和方法，将在PET事件检测时产生的电压脉冲建模为快速线性上升沿，随后是较慢的指数 衰变。 该模型包括与包括衰减常数，峰值电压值和峰值时间相关的PET事件检测的电压脉冲的参数，其由电压脉冲的时间间隔测量确定。 在示例性电子实现中使用比较器和计数器进行时间间隔测量。
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公开(公告)号：US06528793B1
公开(公告)日：2003-03-04
申请号：US09693478
申请日：2000-10-20
申请人： Chin-Tu Chen , Xiaochuan Pan , Chien-Min Kao
发明人： Chin-Tu Chen , Xiaochuan Pan , Chien-Min Kao
IPC分类号： G01T1164
CPC分类号： G01V5/0008 , A61B6/037 , G01T1/2985 , G06T11/005
摘要： A method and apparatus are provided for reconstructing images from data obtained from scintillation events occurring within a projection space of a depth-of-interaction positron emission tomography system. The method includes the steps of identifying a segment of each depth-of-interaction detector of respective pairs of depth-of-interaction detectors detecting the scintillation-events of the data obtained within the projection space and estimating a set of sinograms from the data based upon a set of depth-independent point spread functions of the identified segments of the respective pairs of depth-of-interaction detectors.
摘要翻译： 提供了一种方法和装置，用于根据在相互作用的深度正电子发射断层摄影系统的投影空间内发生的闪烁事件获得的数据重建图像。 该方法包括以下步骤：识别检测在投影空间内获得的数据的闪烁事件的相互对的深度相互作用检测器的每个相互作用检测器的一段，并从基于数据的基础上估计一组中心图 在相应的相互作用深度检测器对的所识别的段的一组与深度无关的点扩展函数上。
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公开(公告)号：US20060113482A1
公开(公告)日：2006-06-01
申请号：US10998509
申请日：2004-11-29
IPC分类号： G01T1/24
CPC分类号： G01T1/1641 , A61N5/1049 , A61N5/1065 , A61N2005/1052 , A61N2005/1061 , G01T1/166
摘要： In some embodiments, an image-guided radiotherapy apparatus and method is provided in which a radiotherapy radiation source and a gamma ray photon imaging device are positioned with respect to a patient area so that a patient can be treated by a beam emitted from the radiotherapy apparatus and can have images taken by the gamma ray photon imaging device. Radiotherapy treatment and imaging can be performed substantially simultaneously and/or can be performed without moving the patient in some embodiments. The gamma ray photon imaging device can be coupled and movable with respect to any part of a building structure, can be located on a portable frame movable to and from the radiotherapy radiation source and patient, or can take other forms. In some embodiments, the gamma ray photon imaging device can be used for imaging in connection with other types of medical interventions.
摘要翻译： 在一些实施例中，提供了一种图像引导放射治疗装置和方法，其中放射治疗辐射源和伽马射线光子成像装置相对于患者区域定位，使得可以通过从放射治疗装置发射的束来对患者进行治疗 并且可以具有由伽马射线光子成像装置拍摄的图像。 在一些实施例中，放射治疗和成像可以基本上同时进行和/或执行而不移动患者。 伽马射线光子成像装置可以相对于建筑结构的任何部分联接和移动，可以位于可移动到放射治疗辐射源和患者的便携式框架上，或者可以采取其他形式。 在一些实施例中，伽马射线光子成像装置可用于与其他类型的医疗干预相结合的成像。
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9.发明授权Automated method and system for the alignment and correlation of images from two different modalities 失效用于两种不同模式的图像对准和相关的自动方法和系统
公开(公告)号：US5974165A
公开(公告)日：1999-10-26
申请号：US523210
申请日：1995-09-05
申请人： Maryellen L. Giger , Chin-Tu Chen , Samuel Armato , Kunio Doi
发明人： Maryellen L. Giger , Chin-Tu Chen , Samuel Armato , Kunio Doi
CPC分类号： G06T7/0012 , G06T3/0075 , G06T7/0083 , G06T7/0091 , G06T7/606 , G06T2207/10116 , G06T2207/30061
摘要： A method and system for the computerized registration of radionuclide images with radiographic images, including generating image data from radiographic and radionuclide images of the thorax. Techniques include contouring the lung regions in each type of chest image, scaling and registration of the contours based on location of lung apices, and superimposition after appropriate shifting of the images. Specific applications are given for the automated registration of radionuclide lungs scans with chest radiographs. The method in the example given yields a system that spatially registers and correlates digitized chest radiographs with V/Q scans in order to correlate V/Q functional information with the greater structural detail of chest radiographs. Final output could be the computer-determined contours from each type of image superimposed on any of the original images, or superimposition of the radionuclide image data, which contains high activity, onto the radiographic chest image.
摘要翻译： 一种用放射性图像计算机化注册放射线图像的方法和系统，包括从放射照相和胸部放射性核素图像生成图像数据。 技术包括在每种类型的胸部图像中轮廓化肺部区域，基于肺顶点的位置缩放和对准轮廓，以及在适当移动图像之后叠加。 给出了用于放射性核素肺扫描的胸部X光照片的自动登记的具体应用。 在给出的示例中的方法产生一个系统，其将数字化胸部X光片与V / Q扫描空间寄存和相关联，以便将V / Q功能信息与胸部X光片的较大结构细节相关联。 最终输出可以是来自叠加在任何原始图像上的每种类型的图像的计算机确定的轮廓，或者包含高活性的放射性核素图像数据叠加到放射照相胸部图像上。
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公开(公告)号：US07265356B2
公开(公告)日：2007-09-04
申请号：US10998509
申请日：2004-11-29
IPC分类号： G01T1/24
CPC分类号： G01T1/1641 , A61N5/1049 , A61N5/1065 , A61N2005/1052 , A61N2005/1061 , G01T1/166
摘要： In some embodiments, an image-guided radiotherapy apparatus and method is provided in which a radiotherapy radiation source and a gamma ray photon imaging device are positioned with respect to a patient area so that a patient can be treated by a beam emitted from the radiotherapy apparatus and can have images taken by the gamma ray photon imaging device. Radiotherapy treatment and imaging can be performed substantially simultaneously and/or can be performed without moving the patient in some embodiments. The gamma ray photon imaging device can be coupled and movable with respect to any part of a building structure, can be located on a portable frame movable to and from the radiotherapy radiation source and patient, or can take other forms. In some embodiments, the gamma ray photon imaging device can be used for imaging in connection with other types of medical interventions.
摘要翻译： 在一些实施例中，提供了一种图像引导放射治疗装置和方法，其中放射治疗辐射源和伽马射线光子成像装置相对于患者区域定位，使得可以通过从放射治疗装置发射的束来对患者进行治疗 并且可以具有由伽马射线光子成像装置拍摄的图像。 在一些实施例中，放射治疗和成像可以基本上同时进行和/或执行而不移动患者。 伽马射线光子成像装置可以相对于建筑结构的任何部分联接和移动，可以位于可移动到放射治疗辐射源和患者的便携式框架上，或者可以采取其他形式。 在一些实施例中，伽马射线光子成像装置可用于与其他类型的医疗干预相结合的成像。
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