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公开(公告)号：US20120277458A1
公开(公告)日：2012-11-01
申请号：US13520691
申请日：2010-10-26
IPC分类号： C07C17/281 , C07C67/347 , C07F5/04 , C07F7/18
CPC分类号： C07F7/1892 , C07C17/272 , C07C49/235 , C07C49/567 , C07C67/293 , C07C67/347 , C07C2601/02 , C07C2602/20 , C07C23/28 , C07C23/04 , C07C23/18 , C07C25/18 , C07C69/63 , C07C69/007 , C07C69/74
摘要： Provided is a method for producing a difluorocyclopropane compound under milder reaction conditions and with high selectivity and high yield. The method for producing a difluorocyclopropane compound of the present invention is characterized by using sodium bromodifluoroacetate as a difluorocyclopropanation agent. With the disclosed method, a difluorocyclopropane compound can be produced under milder reaction conditions and with a higher conversion rate and a higher yield compared to conventional art. Further, by-products can be reduced significantly, thus allowing waste to be greatly reduced. Accordingly, the production method of the present invention is easy to implement industrially (can be employed on an industrial scale) and is thus extremely practical and useful.
摘要翻译： 本发明提供了在较温和的反应条件下以高选择性和高产率制备二氟环丙烷化合物的方法。 本发明的二氟环丙烷化合物的制造方法的特征在于使用溴二氟乙酸钠作为二氟环丙烷化剂。 利用所公开的方法，与常规技术相比，可以在较温和的反应条件下和更高的转化率和更高的收率下制备二氟环丙烷化合物。 此外，可以显着降低副产物，从而允许废物大大减少。 因此，本发明的制造方法在工业上容易实施（可以在工业规模上使用），因此是非常实用和有用的。
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公开(公告)号：US08729320B2
公开(公告)日：2014-05-20
申请号：US13520691
申请日：2010-10-26
IPC分类号： C07C23/04
CPC分类号： C07F7/1892 , C07C17/272 , C07C49/235 , C07C49/567 , C07C67/293 , C07C67/347 , C07C2601/02 , C07C2602/20 , C07C23/28 , C07C23/04 , C07C23/18 , C07C25/18 , C07C69/63 , C07C69/007 , C07C69/74
摘要： Provided is a method for producing a difluorocyclopropane compound under milder reaction conditions and with high selectivity and high yield. The method for producing a difluorocyclopropane compound of the present invention is characterized by using sodium bromodifluoroacetate as a difluorocyclopropanation agent. With the disclosed method, a difluorocyclopropane compound can be produced under milder reaction conditions and with a higher conversion rate and a higher yield compared to conventional art. Further, by-products can be reduced significantly, thus allowing waste to be greatly reduced. Accordingly, the production method of the present invention is easy to implement industrially (can be employed on an industrial scale) and is thus extremely practical and useful.
摘要翻译： 本发明提供了在较温和的反应条件下以高选择性和高产率制备二氟环丙烷化合物的方法。 本发明的二氟环丙烷化合物的制造方法的特征在于使用溴二氟乙酸钠作为二氟环丙烷化剂。 利用所公开的方法，与常规技术相比，可以在较温和的反应条件下和更高的转化率和更高的收率下制备二氟环丙烷化合物。 此外，可以显着降低副产物，从而允许废物大大减少。 因此，本发明的制造方法在工业上容易实施（可以在工业规模上使用），因此是非常实用和有用的。
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