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1.发明授权Antibiotic F-0769, process for its production, and its use as a growth accelerating and feed efficiency increasing agent and as an antitumour agent 失效抗生素F-0769，其生产方法及其作为生长促进剂和饲料效率增加剂和作为抗肿瘤剂的用途
公开(公告)号：US4904470A
公开(公告)日：1990-02-27
申请号：US21125
申请日：1987-03-03
申请人： Hideo Sugawara , Tomonori Takashina , Nobuko Takahashi , Machiko Sugiyama , Akio Seino , Yukio Miyazaki
发明人： Hideo Sugawara , Tomonori Takashina , Nobuko Takahashi , Machiko Sugiyama , Akio Seino , Yukio Miyazaki
CPC分类号： C12P1/06 , A23K20/195 , A23K50/30
摘要： An antibiotic F-0769 having the following properties:(1) Outer appearance: White or light yellow powder,(2) Melting point: 245.degree.-250.degree. C.,(3) Specific rotation: [.alpha.].sub.D.sup.25 =-37.5.degree. (c=1, methanol),(4) Solubility in solvents: Soluble in methanol, ethanol, acetone, chloroform, ethyl acetate and benzene; and insoluble in water and hexane,(5) Elementary analysis (found %): C:57.53, H:7.36, O:21.17, N:12.97,(6) Ultraviolet absorption spectrum (as measured in methanol: As shown in FIG. 1, .lambda.max(E.sub.1 cm.sup.1%)=213 nm (466), 286 nm (200)(7) Infrared absorption spectrum (as measured by KBr method): As shown in FIG. 2,(8) Nuclear magnetic resonance spectra (as measured in heavy chloroform): .sup.1 H-NMR spectrum is as shown in FIG. 3, and .sup.13 C-NMR spectrum is as shown in FIG. 4,(9) Distinction among basicity, acidity and neutrality: Neutral substance,(10) Amino acid analysis: As a result of the hydrolysis with 6N hydrochloric acid at 110.degree. C. for 18 hours, amino acids i.e. threonine, valine and leucine were detected,(11) Color reactions: Positive in the iodine reaction and in the potassium permanganate reaction; and negative in the ninhydrin reaction and in the ferric chloride reaction,(12) Thin layer chromatography (by means of silica gel, Art, 5715, manufactured by Merck Co.):______________________________________ Solvent system Rf value ______________________________________ Ethyl acetate 0.16 Ethyl acetate-methanol (5:1) 0.33 Chloroform-methanol (10:1) 0.68 Ethyl acetate-acetone (1:1) 0.31 Acetone-benzene (5:1) 0.40 ______________________________________ (13) Molecular weight (as measured by Rast method): About 745
摘要翻译： 具有以下性质的抗生素F-0769：（1）外观：白色或浅黄色粉末，（2）熔点：245〜-250℃，（3）比旋光度：αD25= -37.5° （c = 1，甲醇），（4）溶剂中的溶解度：溶于甲醇，乙醇，丙酮，氯仿，乙酸乙酯和苯; 并且不溶于水和己烷，（5）元素分析（发现％）：C：57.53，H：7.36，O：21.17，N：12.97，（6）紫外吸收光谱（在甲醇中测定： 1，λmax（E1cm1％）= 213nm（466），286nm（200）（7）红外吸收光谱（通过KBr法测定）：如图2所示，（8）核磁共振谱 如在重氯仿中测得）：1 H-NMR光谱如图3所示，13C-NMR谱如图4所示，（9）碱度，酸度和中性之间的区别：中性物质，（10）氨基 酸分析：由于6N盐酸在110℃水解18小时，检测出氨基酸，即苏氨酸，缬氨酸和亮氨酸，（11）色素反应：碘反应和高锰酸钾反应中呈阳性 ;在茚三酮反应和氯化铁反应中为负，（12）薄层色谱法（通过硅胶，Art，5715，由Merck Co.制造）： - 溶剂sy 茎Rf值乙酸乙酯0.16-乙酸乙酯 - 甲醇（5:1）0.33-氯仿 - 甲醇（10:1）0.68乙酸乙酯 - 丙酮（1:1）0.31-乙酮 - 苯（5:1）0.40- （13）分子量（用Rast法测定）：约745
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