摘要:
[Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analog thereof being replaced with a glycosylated amino acid.
摘要:
[Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analog thereof being replaced with a glycosylated amino acid.
摘要:
[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids.
摘要:
[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids.
摘要:
Disclosed is a synthetic AILIM extracellular domain which has high ligand-binding ability and a quality sufficient for a pharmaceutical product. Also disclosed is a method for synthesizing the synthetic AILIM extracellular domain. Specifically disclosed is a sugar chaim-added AILIM extracellular domain wherein a sugar chain is bound at a position corresponding to the 69-position of the amino acid sequence of human AILIM extracellular domain, said amino acid sequence being depicted in SEQ ID NO: 7, and no sugar chain is added at positions corresponding to the 3-position and the 90-position of the amino acid sequence.
摘要翻译:公开了具有高配体结合能力和足够用于药物产品的质量的合成的AILIM细胞外结构域。 还公开了合成AILIM胞外结构域的方法。 具体公开的是加入糖链的AILIM细胞外结构域,其中糖链在对应于人AILIM细胞外结构域的氨基酸序列的69位的位置上结合,所述氨基酸序列如SEQ ID NO:7所示, 并且在对应于氨基酸序列的3-位和90位的位置处不添加糖链。
摘要:
Disclosed is a glucagon-like peptide-1 (GLP-1) analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity. Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid.
摘要:
A process for making a relief printing plate is provided that includes (1) a step of crosslinking by means of heat and/or light a relief-forming layer formed from a resin composition containing (Component A) a compound having a hydrolyzable silyl group and/or a silanol group, (Component B) a thermoplastic elastomer, and (Component C) a polymerizable compound, and (2) a step of forming a relief layer by laser-engraving the crosslinked relief-forming layer.
摘要:
A relief printing plate precursor for laser engraving, including a relief forming layer formed by thermally crosslinking a resin composition including (A) a polymer having an ethylenically unsaturated bond in a side chain wherein the polymer is an acrylic resin or a polyvinyl acetal, (B) carbon black, and (C) a thermopolymerization initiator.
摘要:
There are provided a resin composition for laser engraving that can give a relief printing plate having excellent hardness, film elasticity, printing durability, and aqueous ink transfer properties and that has excellent rinsing properties for engraving residue generated when laser-engraving a printing plate and excellent engraving sensitivity in laser engraving, a relief printing plate precursor employing the resin composition for laser engraving, a process for producing a relief printing plate employing the same, and a relief printing plate obtained thereby.
摘要:
The invention provides a resin composition for laser engraving, containing at least (A) a polymerizable compound having two or more ethylenic unsaturated bonds, a carbon-sulfur bond being contained at the site where two among the two or more ethylenic unsaturated bonds are connected and (B) a binder polymer. The invention further provides an image forming material containing the resin composition, a relief printing plate precursor having a relief forming layer which contains the resin composition, a relief printing plate precursor having a relief forming layer which contains a product formed by subjecting the resin composition to cross-linking, a method for manufacturing a relief printing plate including subjecting the relief printing plate precursor having the relief forming layer which contains the resin composition to cross-linking, and a relief printing plate manufactured by the manufacturing method.