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1.发明授权公开(公告)号：US07732583B2
公开(公告)日：2010-06-08
申请号：US10545421
申请日：2004-02-13
申请人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
发明人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
CPC分类号： C07D317/28 , C07C247/04 , C07H15/04 , C07H15/26
摘要： Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds.Glycolipids having the formula (I): where R3 indicates a substituted or unsubstituted C1 to C7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R8 indicates a substituted or unsubstituted C1 to C35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
摘要翻译： 新型糖脂衍生物，其中鞘氨醇碱基部分的取代基为短碳链烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，以及用于实际大量生产其的中间体的有效合成方法 可用于合成这些化合物。 具有式（I）的糖脂：其中R3表示取代或未取代的C1至C7直链烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，R8表示取代或未取代的C1至C35 烷基，取代或未取代的芳基或取代或未取代的芳烷基是化学合成的。
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2.发明申请公开(公告)号：US20060074235A1
公开(公告)日：2006-04-06
申请号：US10545421
申请日：2004-02-13
申请人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
发明人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
IPC分类号： C08B37/00
CPC分类号： C07D317/28 , C07C247/04 , C07H15/04 , C07H15/26
摘要： Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. Glycolipids having the formula (I): where R3 indicates a substituted or unsubstituted C1 to C7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R8 indicates a substituted or unsubstituted C1 to C35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
摘要翻译： 新型糖脂衍生物，其中鞘氨醇碱基部分的取代基为短碳链烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，以及用于实际大规模生产的中间体的有效合成方法 可用于合成这些化合物。 具有式（I）的糖脂：其中R 3表示取代或未取代的C 1至C 7直链烷基，取代或未取代的环烷基 基团，取代或未取代的芳基或取代或未取代的芳烷基，R 8表示取代或未取代的C 1至C 35烷基的C 1〜 取代或未取代的芳基或取代或未取代的芳烷基是化学合成的。
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3.发明授权公开(公告)号：US08034908B2
公开(公告)日：2011-10-11
申请号：US12760793
申请日：2010-04-15
申请人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
发明人： Hirokazu Annoura , Kenji Murata , Takashi Yamamura
CPC分类号： C07D317/28 , C07C247/04 , C07H15/04 , C07H15/26
摘要： Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds.Glycolipids having the formula (I): where R3 indicates a substituted or unsubstituted C1 to C7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R8 indicates a substituted or unsubstituted C1 to C35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
摘要翻译： 新型糖脂衍生物，其中鞘氨醇碱基部分的取代基为短碳链烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，以及用于实际大量生产其的中间体的有效合成方法 可用于合成这些化合物。 具有式（I）的糖脂：其中R3表示取代或未取代的C1至C7直链烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，R8表示取代或未取代的C1至C35 烷基，取代或未取代的芳基或取代或未取代的芳烷基是化学合成的。
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4.发明申请Therapeutic Drug for Suppressing Functions of NKT Cells Containing Glycolipid Derivative as Active Ingredient 审中-公开用于抑制含有糖脂衍生物作为活性成分的NKT细胞功能的治疗药物公开(公告)号：US20090048185A1
公开(公告)日：2009-02-19
申请号：US12084039
申请日：2006-10-27
IPC分类号： A61K31/7032 , C07H15/02 , A61P1/02 , A61P1/04 , A61P3/10 , A61P5/14 , A61P5/50 , A61P7/00 , A61P7/06 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/04 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P21/04 , A61P25/00 , A61P29/00 , A61P37/02
CPC分类号： A61K31/7032
摘要： A therapeutic drug for diseases, in which NKT cells or stimulus of NKT cells is involved in deterioration of disease conditions, containing, as an active ingredient, a glycolipid derivative having the formula (I): wherein R1 indicates an aldopyranose residue, R2 indicates a hydrogen atom or a hydroxy group, A indicates —CH2—, —CH(OH)—CH2— or —CH═CHCH2—, x indicates an integer of 13 to 16 and y indicates an integer of 0 to 25 or its pharmacologically acceptable hydrate or solvate.
摘要翻译： 一种治疗药物，其中NKT细胞或NKT细胞的刺激参与疾病病症的恶化，其含有具有式（I）的糖脂衍生物作为活性成分：其中R1表示吡喃葡萄糖残基，R2表示 氢原子或羟基，A表示-CH 2 - ， - CH（OH）-CH 2 - 或-CH-CHCH 2 - ，x表示13〜16的整数，y表示0〜25的整数或其药理学上可接受的水合物 或溶剂化物。
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公开(公告)号：US20110220429A1
公开(公告)日：2011-09-15
申请号：US13114312
申请日：2011-05-24
IPC分类号： B60K11/00
CPC分类号： B60K11/00
摘要： An all terrain vehicle contains a partition wall which partitions a passenger space and a hood which is arranged ahead of the partition wall. When viewed from the side of the vehicle, an air outlet of an exhaust passage is opened in an upper space located between the partition wall and the hood.
摘要翻译： 全地形车辆包含分隔乘客空间的分隔壁和布置在分隔壁前方的罩。 当从车辆侧观察时，排气通道的出气口位于分隔壁和罩之间的上部空间中。
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公开(公告)号：US20100194087A1
公开(公告)日：2010-08-05
申请号：US12365541
申请日：2009-02-04
申请人： Takashi Yamamura , Motoyuki Hara
发明人： Takashi Yamamura , Motoyuki Hara
IPC分类号： B62D21/00
CPC分类号： B62D25/084
摘要： A vehicle including a main body frame having a length direction and a width direction includes a front frame carried by the main body frame. The front frame includes a first front cross frame having a generally height and extends along said main body's width direction. A second front cross frame is disposed frontward and offset from the first cross frame at an elevational height less than the first front cross frame. A first and second side frame interconnect with the first cross frame and the second cross frame to define radiator cage having an interior space. A radiator is disposed within the interior space of said radiator cage.
摘要翻译： 包括具有长度方向和宽度方向的主体框架的车辆包括由主体框架承载的前框架。 前框架包括具有大致高度并沿所述主体的宽度方向延伸的第一前横框架。 第二前横框架向前设置并且在比第一前十字架小的高度偏移处从第一横框架偏移。 第一和第二侧框架与第一横框架和第二横框架互连以限定具有内部空间的散热器保持架。 散热器设置在所述散热器笼的内部空间内。
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公开(公告)号：US20100187032A1
公开(公告)日：2010-07-29
申请号：US12362130
申请日：2009-01-29
CPC分类号： B60K11/00
摘要： An all terrain vehicle contains a partition wall which partitions a passenger space and a hood which is arranged ahead of the partition wall. When viewed from the side of the vehicle, an air outlet of an exhaust passage is opened in an upper space located between the partition wall and the hood.
摘要翻译： 全地形车辆包含分隔乘客空间的分隔壁和布置在分隔壁前方的罩。 当从车辆侧观察时，排气通道的出气口位于分隔壁和罩之间的上部空间中。
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公开(公告)号：US20090184541A1
公开(公告)日：2009-07-23
申请号：US12361605
申请日：2009-01-29
申请人： Takashi Yamamura , Craig Smith
发明人： Takashi Yamamura , Craig Smith
CPC分类号： B62D23/005 , B60N2/005 , B60N2/06 , B60N2/3011 , B60N2/305 , B60N2/686 , B60N2/803 , B62D25/04
摘要： A utility vehicle including: a vehicle body frame having a left and right side portion; a front seat affixed to the vehicle body frame; a rear seat affixed to the vehicle body frame provided to the rear of the front seat; a rear floor affixed to the vehicle body frame provided between the front seat and the rear seat; a first roof support structure including a first left member and first right pipe member that extend generally in the vertical direction from the vehicle body frame, disposed respectively at the left and right side portions of the vehicle body frame in front of the front seat; a second roof support structure including a second left member and a second right pipe member that extend generally in the vertical direction from the vehicle body frame, disposed respectively at the left and right side portions of the vehicle body frame to the rear of the front seat, wherein at least a portion of the second left pipe member and second right pipe member are positioned lower than a seating surface of a seat cushion portion of the rear seat and are angled so as to be positioned further towards the front seat; a third roof support structure including a third left member and third right pipe member that extend generally in the vertical direction from the vehicle body frame, disposed respectively at both the left and right side portions of the vehicle body frame to the rear of the rear seat, wherein at least a downward direction portion of the third left pipe member and third right pipe member are positioned lower than the seating surface of the seat cushion portion of the rear seat and are angled so as to be positioned further towards the back the higher up; and a roof member that connects to an upper portion of the first roof support structure, an upper portion of the second roof support structure, and an upper portion of the third roof support structure.
摘要翻译： 一种多用途车，包括：具有左右侧部的车体框架; 固定在车体框架上的前排座椅; 固定在车身框架上的后座椅，其设置在前座椅的后部; 设置在前座和后座之间的车身框架上的后地板; 第一屋顶支撑结构，其包括分别位于前座椅前方的车身框架的左侧和右侧部分的大致沿着垂直方向从车体框架延伸的第一左构件和第一右管构件; 第二屋顶支撑结构，包括第二左侧构件和第二右侧管构件，其大致沿着垂直方向从车身框架延伸，分别设置在车身框架的左侧和右侧部分到前座椅的后部 其中，所述第二左管构件和所述第二右管构件的至少一部分定位成比所述后座椅的座垫部的座面低，并且成角度以进一步朝向所述前座定位; 第三屋顶支撑结构，包括第三左侧构件和第三右侧管构件，其大致沿着垂直方向从车身框架延伸，分别设置在车身框架的左侧和右侧部分到后座椅的后部 其特征在于，所述第三左管件和所述第三右管件的至少向下方向部分位于所述后座椅的所述座垫部分的所述座表面的下方并且成角度以进一步朝向所述后方更高的位置 ; 以及屋顶构件，其连接到第一屋顶支撑结构的上部，第二屋顶支撑结构的上部和第三屋顶支撑结构的上部。
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9.发明申请Novel glycolipid and medicine for autoimmune disease containing the same as active ingredient 有权新型糖脂和含有与活性成分相同的自身免疫性疾病的药物公开(公告)号：US20060148723A1
公开(公告)日：2006-07-06
申请号：US10486948
申请日：2002-08-14
申请人： Takashi Yamamura , Sachiko Miyake
发明人： Takashi Yamamura , Sachiko Miyake
IPC分类号： A61K31/739
CPC分类号： C07H15/10 , A61K31/7028
摘要： The invention is a glycolipid useful in treating autoimmune diseases and a medicine thereof as active ingredient for autoimmune diseases, wherein R1 is an aldopyranose group, R2 is a hydrogen atom or a hydroxyl group, R3 is —CH2—, —CH(OH)—CH2— or —CH═CH—, R4 is a hydrogen atom or CH3, x is 0-35, y and z represent integers satisfying y+z=0-3.
摘要翻译： 本发明是用于治疗自身免疫性疾病的糖脂及其作为自身免疫性疾病的有效成分的药物，其中R 1为吡喃葡萄糖基，R 2为氢原子或 羟基，R 3是-CH 2 - ， - CH（OH）-CH 2 - 或-CH-CH-，R 4是氢原子或CH 3，x是0-35，y和z表示满足y + z = 0-3的整数。
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公开(公告)号：US20050253353A1
公开(公告)日：2005-11-17
申请号：US11127523
申请日：2005-05-12
IPC分类号： B60G3/18
CPC分类号： B60G3/20 , B60G7/00 , B60G2200/144 , B60G2200/422 , B60G2204/143 , B60G2204/15 , B60G2204/19 , B60G2206/60 , B60G2300/124
摘要： A vehicle includes a wheel suspension device on a right side and a wheel suspension device on a left side, with the right and left side wheel suspension devices being connected to each other through a rear frame mounted on a body frame. The right and left side wheel suspension devices include a lower arm supported at an inner end of the rear frame so as to extend outward and so as to be pivotally movable in a vertical direction. The right and left side wheel suspension devices also include an upper arm connected to the outer end of the lower arm through a wheel-supporting knuckle and so as to extend outward from the knuckle. The wheel suspension devices are provided with a rear cushion unit connected at one end to the swinging side end of one of the lower and upper arm members. At least one of the inner end of the upper arm and the other end of the rear cushion unit is supported on the rear frame so as to be pivotally movable.
摘要翻译： 车辆包括右侧的车轮悬挂装置和左侧的车轮悬挂装置，左右侧轮悬挂装置通过安装在车体框架上的后架彼此连接。 右侧和左侧悬架装置包括支撑在后框架的内端处的下臂，以便向外延伸并且能够在垂直方向上枢转地运动。 右侧和左侧车轮悬挂装置还包括通过轮支撑转向节连接到下臂的外端并且从转向节向外延伸的上臂。 车轮悬挂装置设置有后缓冲单元，其一端连接到下臂构件和上臂构件之一的摆动侧端部。 上臂的内端和后缓冲单元的另一端中的至少一个被支撑在后框架上以便可枢转地移动。
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