公开(公告)号：US20180280300A1

公开(公告)日：2018-10-04

申请号：US15766641

申请日：2016-10-06

申请人： Hiroki HAMADA ,  Yoshio SHIMIZU ,  ENSUIKO SUGAR REFINING CO., LTD. ,  National University Corporation Okayama University

发明人： Hiroki HAMADA ,  Masaharu SENO ,  Tomonari KASAI ,  Tsukasa SHIGEHIRO ,  Koji HARA ,  Tetsuya ITO ,  Ichiro FUJIWARA

IPC分类号： A61K9/127 ,  A61K31/337 ,  A61K31/7048 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34

摘要： An object of the present invention is to provide a method for encapsulating a poorly water-soluble pharmacologically active substance in a liposome with high efficiency.The present invention provides a composition comprising a lipid having a phosphatidylcholine group, a cholesterol compound, a lipid having a phosphatidylethanolamine group, and a poorly water-soluble pharmacologically active substance, wherein the molar ratio of the lipid having a phosphatidylcholine group, the cholesterol compound, the lipid having a phosphatidylethanolamine group, and the poorly water-soluble pharmacologically active substance is 3 to 8:2 to 7:0.1 to 3:0.001 to 5, respectively.

公开(公告)号：US20160256566A2

公开(公告)日：2016-09-08

申请号：US14386855

申请日：2013-03-22

申请人： ENSUIKO SUGAR REFINING CO., LTD. ,  Hiroki HAMADA ,  Ichiro FUJIWARA ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki HAMADA ,  Ichiro FUJIWARA ,  Masaharu SENO ,  Tomonari KASAI ,  Tsukasa SHIGEHIRO ,  Masaharu MURAKAMI ,  Katsuhiko MIKUNI

IPC分类号： A61K47/48 ,  A61K31/337

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.