公开(公告)号：US20180280300A1

公开(公告)日：2018-10-04

申请号：US15766641

申请日：2016-10-06

申请人： Hiroki HAMADA ,  Yoshio SHIMIZU ,  ENSUIKO SUGAR REFINING CO., LTD. ,  National University Corporation Okayama University

发明人： Hiroki HAMADA ,  Masaharu SENO ,  Tomonari KASAI ,  Tsukasa SHIGEHIRO ,  Koji HARA ,  Tetsuya ITO ,  Ichiro FUJIWARA

IPC分类号： A61K9/127 ,  A61K31/337 ,  A61K31/7048 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34

摘要： An object of the present invention is to provide a method for encapsulating a poorly water-soluble pharmacologically active substance in a liposome with high efficiency.The present invention provides a composition comprising a lipid having a phosphatidylcholine group, a cholesterol compound, a lipid having a phosphatidylethanolamine group, and a poorly water-soluble pharmacologically active substance, wherein the molar ratio of the lipid having a phosphatidylcholine group, the cholesterol compound, the lipid having a phosphatidylethanolamine group, and the poorly water-soluble pharmacologically active substance is 3 to 8:2 to 7:0.1 to 3:0.001 to 5, respectively.

公开(公告)号：US20160256566A2

公开(公告)日：2016-09-08

申请号：US14386855

申请日：2013-03-22

申请人： ENSUIKO SUGAR REFINING CO., LTD. ,  Hiroki HAMADA ,  Ichiro FUJIWARA ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki HAMADA ,  Ichiro FUJIWARA ,  Masaharu SENO ,  Tomonari KASAI ,  Tsukasa SHIGEHIRO ,  Masaharu MURAKAMI ,  Katsuhiko MIKUNI

IPC分类号： A61K47/48 ,  A61K31/337

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

公开(公告)号：US20150079626A1

公开(公告)日：2015-03-19

申请号：US14218253

申请日：2014-03-18

申请人： LSIP, LLC ,  National University Corporation Okayama University

发明人： Masaharu SENO ,  Akifumi MIZUTANI ,  Tomonari KASAI

IPC分类号： G01N33/50 ,  C12N5/095

CPC分类号： G01N33/5011 ,  A61K35/13 ,  A61K35/545 ,  C12N5/0693 ,  C12N5/0695 ,  C12N2501/40 ,  C12N2501/905 ,  C12N2502/30 ,  C12N2506/45 ,  G01N33/5073 ,  G01N2500/04

摘要： The present invention relates to a method of obtaining a cell population containing cancer stem cells, which comprises culturing iPS cells in the presence of culture supernatant of cancer cells.

摘要翻译： 本发明涉及一种获得含有癌干细胞的细胞群的方法，该方法包括在癌细胞的培养物上清液存在下培养iPS细胞。