Benzothiazole derivatives
    1.
    发明授权
    Benzothiazole derivatives 失效
    苯并噻唑衍生物

    公开(公告)号:US5900426A

    公开(公告)日:1999-05-04

    申请号:US624746

    申请日:1996-03-27

    IPC分类号: C07D277/64 A61K31/415

    CPC分类号: C07D277/64

    摘要: Benzothiazole derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component possess a lipid lowering activity and are useful pharmaceuticals for the treatment of hyperlipemia. The lipid lowering agents are of the formula: ##STR1## wherein R.sub.1 is halogen, trifluoromethyl, acetamido or --OX.sub.1 ; X.sub.1 is hydrogen, alkyl or acyl; R.sub.2 is hydrogen, halogen, alkyl, hydroxyalkyl, trifluoromethyl, nitro, amino which may be substituted with alkyl or acyl, carboxy which may be esterified with alkyl, or --OX.sub.2 ; X.sub.2 is hydrogen, alkyl, acyl, carboxyalkyl which may be esterified with alkyl; n is an integer from 1 to 3 denoting the number of substituents R.sub.2 ; and plural R.sub.2 may be the same or different when n is 2 or 3; with the proviso that R.sub.1 is a group other than halogen when R.sub.2 is hydrogen. The benzothiazole derivatives and their pharmaceutically acceptable salts significantly decrease cholesterol, triglyceride and low-density lipoprotein in blood.

    摘要翻译: 苯并噻唑衍生物,其药学上可接受的盐和含有所述化合物作为有效成分的治疗剂具有降脂活性,并且是用于治疗高脂血症的有用药物。 降脂剂具有下式:其中R1是卤素,三氟甲基,乙酰氨基或-OX1; X1是氢,烷基或酰基; R 2是氢,卤素,烷基,羟基烷基,三氟甲基,硝基,可被烷基或酰基取代的氨基,可以被烷基或-OX 2酯化的羧基; X 2是可以被烷基酯化的氢,烷基,酰基,羧基烷基; n是1至3的整数,表示取代基R2的数目; 当n为2或3时,多个R2可以相同或不同; 条件是当R 2为氢时,R 1为卤素以外的基团。 苯并噻唑衍生物及其药学上可接受的盐显着降低血液中的胆固醇,甘油三酯和低密度脂蛋白。

    Openable roof apparatus
    3.
    发明授权
    Openable roof apparatus 失效
    OPENABLE屋顶装置

    公开(公告)号:US5117594A

    公开(公告)日:1992-06-02

    申请号:US502613

    申请日:1990-03-30

    IPC分类号: E04B1/343 E04B1/344 E04B7/16

    摘要: In an openable roof apparatus for a space, a stationary support structure is arranged about the space. A movable roof structure is supported by the stationary support structure and is movable with respect thereto. The movable roof structure having a first movable roof section and a second swing roof section. The second swing roof section is movable angularly about the central axis of the space with respect to the first movable roof section and is capable of being overlapped therewith. A guide arrangement is arranged on the stationary support structure and extends perpendicularly to a central axis of the space. The first movable roof section and the second swing roof section, which are overlapped with each other, are movable along the guide arrangement toward and away from the space.

    摘要翻译: 在用于空间的可开启屋顶装置中,围绕该空间设置固定支撑结构。 可移动屋顶结构由固定支撑结构支撑并且可相对于其移动。 所述可动屋顶结构具有第一可移动顶部和第二摆动顶部。 第二摆动屋顶部分可相对于第一可移动屋顶部分围绕空间的中心轴线成角度地移动并且能够与其重叠。 引导装置布置在固定支撑结构上并且垂直于该空间的中心轴线延伸。 彼此重叠的第一活动屋顶部分和第二摆动屋顶部分可沿导向装置移动并朝向空间移动。

    Openable roof apparatus
    5.
    发明授权
    Openable roof apparatus 失效
    OPENABLE屋顶装置

    公开(公告)号:US5063730A

    公开(公告)日:1991-11-12

    申请号:US502170

    申请日:1990-03-29

    IPC分类号: E04B1/343 E04B1/344 E04B7/16

    摘要: In an openable roof apparatus for a space, a first and a second movable roof structures have their respective both ends which are supported respectively by a pair of stationary support structures for movement therealong. A pair of guide arrangements are arranged respectively on the pair of stationary support structures. The first and second movable roof structures are movable toward and away from each other along the guide arrangements. The first movable roof structure includes a plurality of movavble roof units having their respective axes which extend perpendicularly to the guide arrangements. The first and second movable roof structures are movable between a closed position where the movable roof units of the first movable roof structure cooperate with the second movable roof structure to close the space, and an open position where the movable roof units of the first movable roof structure are moved away from the second movable roof structure to open the space. In the open position, the movable roof units of the first movable roof structure are overlapped with each other.

    摘要翻译: 在用于空间的可开启的屋顶装置中,第一和第二可移动屋顶结构的相应的两端分别由用于在其上移动的一对固定支撑结构支撑。 一对引导装置分别布置在一对固定支撑结构上。 第一和第二可移动屋顶结构沿着引导装置可彼此移动并远离彼此。 第一活动屋顶结构包括多个具有垂直于导向装置延伸的各自的轴的活动屋顶单元。 第一和第二可移动屋顶结构可在关闭位置之间移动,在该关闭位置,第一可移动屋顶结构的可动屋顶单元与第二可移动屋顶结构配合以封闭空间;以及打开位置,第一可移动屋顶的可动屋顶单元 结构被移动离开第二可动屋顶结构以打开空间。 在打开位置,第一可移动屋顶结构的可动屋顶单元彼此重叠。