-
公开(公告)号：US20050130302A1
公开(公告)日：2005-06-16
申请号：US10952460
申请日：2004-09-28
IPC分类号： A61K35/12 , A61K48/00 , C07K14/82 , C07K16/28 , C12N5/076 , C12N5/0789 , C12N5/0797 , C12N5/08
CPC分类号： C12N5/061 , A61K48/00 , A61K2035/124 , C07K14/82 , C07K16/28 , C12N5/0623 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2501/998
摘要： A method and substance for regulating expansion of a stem cell, such as a hematopoietic stem cell, is provided. Therefore, a method is provided for regulating expansion of a stem cell, such as a hematopoietic stem cell, a germ line stem cell, or a neural stem cell, comprising the steps of (A) providing, to the stem cell, Bmi-1 or a variant or fragment thereof and/or a Bmi-1 regulating agent in an amount sufficient for regulation of the expansion of the stem cell and (B) culturing the stem cell for a time sufficient for the regulation of expansion.
摘要翻译： 提供了用于调节干细胞扩增的方法和物质，例如造血干细胞。 因此，提供了一种用于调节干细胞如造血干细胞，胚系干细胞或神经干细胞的扩增的方法，包括以下步骤：（A）向干细胞提供Bmi-1 或其变体或片段和/或Bmi-1调节剂，其量足以调节干细胞的扩增，和（B）培养干细胞足以调节扩张的时间。
-
公开(公告)号：US20060177932A1
公开(公告)日：2006-08-10
申请号：US10534386
申请日：2003-10-23
申请人： Hiromitsu Nakauchi , Atsushi Iwama
发明人： Hiromitsu Nakauchi , Atsushi Iwama
IPC分类号： A61K38/17 , C12N15/867 , C12N5/08
CPC分类号： C12N5/0647 , C07K14/4705 , C12N2501/125 , C12N2501/145 , C12N2501/26
摘要： The present invention relates to a method and substance for maintaining the pluripotency and self-replication ability of a stem cell, such as a hematopoietic stem cell, while keeping it undifferentiated. Specifically, the present invention provides a composition for maintaining the expansion or pluripotency of a stem cell, comprising active STAT5, and a method using the same. STAT5 may be in the form of a protein or a nucleic acid. The composition may contain a cellular physiologically active substance (e.g., SCF, TPO, Flt-3L, etc.). The present invention also relates to a cell, a tissue and an organ prepared from the stem cell.
摘要翻译： 本发明涉及一种保持干细胞如造血干细胞的多能性和自我复制能力的方法和物质，同时保持其未分化。 具体地，本发明提供了用于维持包含活性STAT5的干细胞的扩增或多能性的组合物及其使用方法。 STAT5可以是蛋白质或核酸的形式。 组合物可以含有细胞生理活性物质（例如SCF，TPO，Flt-3L等）。 本发明还涉及从干细胞制备的细胞，组织和器官。
-
公开(公告)号：US09187728B2
公开(公告)日：2015-11-17
申请号：US13704424
申请日：2011-06-13
申请人： Taito Nishino , Atsushi Iwama
发明人： Taito Nishino , Atsushi Iwama
IPC分类号： A61K38/00 , C12N5/00 , C12N5/0789 , A61K31/122 , A61K31/352
CPC分类号： C12N5/0647 , A61K31/122 , A61K31/352 , C12N2500/62 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2501/72 , C12N2501/727 , C12N2501/999
摘要： An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided.A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R6 are as defined in the description).
摘要翻译： 提供了用作造血干细胞和/或造血祖细胞的扩增剂，其用作各种造血疾病的治疗，并且可用于提高基因转移到造血干细胞中用于基因治疗的效率。 一种产生造血干细胞和/或造血祖细胞的方法，其包括通过在下列通式（I）表示的化合物存在下体外培养造血干细胞来扩大造血干细胞，其中所述化合物的互变异构体或药学上可接受的盐 化合物或其溶剂合物（其中R1至R6如说明书中所定义）。
-
公开(公告)号：US20130095085A1
公开(公告)日：2013-04-18
申请号：US13704424
申请日：2011-06-13
申请人： Taito Nishino , Atsushi Iwama
发明人： Taito Nishino , Atsushi Iwama
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K31/122 , A61K31/352 , C12N2500/62 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2501/72 , C12N2501/727 , C12N2501/999
摘要： An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided.A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R6 are as defined in the description).
摘要翻译： 提供了用作造血干细胞和/或造血祖细胞的扩增剂，其用作各种造血疾病的治疗，并且可用于提高基因转移到造血干细胞中用于基因治疗的效率。 一种产生造血干细胞和/或造血祖细胞的方法，其包括通过在下列通式（I）表示的化合物存在下体外培养造血干细胞来扩大造血干细胞，其中所述化合物的互变异构体或药学上可接受的盐 化合物或其溶剂合物（其中R1至R6如说明书中所定义）。
-
-
-
搜索结果
4 条记录 (耗时 0.014 秒)
