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13 条记录 (耗时 0.022 秒)

    NUCLEIC ACID DRUG FOR TREATMENT OF ALLERGIC DISEASE
    1.
    发明申请
    NUCLEIC ACID DRUG FOR TREATMENT OF ALLERGIC DISEASE 审中-公开
    用于治疗过敏性疾病的核酸药物

    公开(公告)号：US20110300182A1

    公开(公告)日：2011-12-08

    申请号：US13119080

    申请日：2009-03-12

    申请人： Hiroo Yokozeki ,  Kazuki Hosoya ,  Takahiro Satoh ,  Yasuhisa Nemoto

    发明人： Hiroo Yokozeki ,  Kazuki Hosoya ,  Takahiro Satoh ,  Yasuhisa Nemoto

    IPC分类号： A61K31/713 ,  C12N15/63 ,  A61P29/00 ,  A61P37/08 ,  A61P17/00 ,  A61P11/06 ,  C07H21/02 ,  A61K48/00

    CPC分类号： C12N15/113 ,  C12N2310/14

    摘要： This invention provides double-stranded (ds) RNA capable of suppressing the expression of STAT6 related to allergic diseases mediated by Th2-type cytokines via RNA interference and a pharmaceutical composition for prevention or treatment of allergic diseases comprising such dsRNA. Such dsRNA is a double-stranded RNA (dsRNA) molecule targeting mRNA of the STAT6 gene composed of (a) or (b): (a) a sense strand identical to a sequence having 15 to 50 continuous nucleotides in the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand; or (b) a sense strand comprising a sequence derived from the sequence comprising 15 to 50 continuous nucleotides of the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 by deletion, substitution, or addition of 1 or several nucleotides and capable of hybridizing to the STAT6 gene and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand.

    摘要翻译： 本发明提供能够通过RNA干扰抑制由Th2型细胞因子介导的过敏性疾病的STAT6表达的双链（ds）RNA和用于预防或治疗包含这种dsRNA的过敏性疾病的药物组合物。 这种dsRNA是靶向由（a）或（b）组成的STAT6基因mRNA的双链RNA（dsRNA）分子：（a）与在STAT6基因序列中具有15至50个连续核苷酸的序列相同的有义链代表 通过SEQ ID NO：1或3和包含与有义链的核苷酸序列互补的核苷酸序列的反义链; 或（b）含有由SEQ ID NO：1或3表示的STAT6基因序列的15〜50个连续核苷酸的序列衍生的有义链，通过缺失，取代或添加1个或几个核苷酸并且能够杂交 到STAT6基因和包含与有义链的核苷酸序列互补的核苷酸序列的反义链。

    Modification process of synthetic silica powder and its quartz glass product
    3.
    发明授权
    Modification process of synthetic silica powder and its quartz glass product 有权
    合成二氧化硅粉及其石英玻璃制品的改性工艺

    公开(公告)号：US08053080B2

    公开(公告)日：2011-11-08

    申请号：US12768904

    申请日：2010-04-28

    申请人： Masanori Fukui ,  Takahiro Satoh

    发明人： Masanori Fukui ,  Takahiro Satoh

    IPC分类号： B32B13/04 ,  B32B17/06 ,  A47G19/22

    CPC分类号： C30B35/002 ,  C03B19/1065 ,  C03B2201/04 ,  C03B2201/20 ,  C03C1/026 ,  C30B15/10 ,  Y10T117/10 ,  Y10T428/13 ,  Y10T428/131 ,  Y10T428/1317

    摘要： A modification process of the synthetic quartz powder, which can make a quartz glass product hardly having bubbles at the time of fusing, is provided, along with a modification process of the synthetic quartz powder and a glass product using said modified quartz powder are provided, wherein the synthetic quartz powder is kept in helium atmosphere at least in the temperature falling process, when the amorphous synthetic quartz powder produced by the sol-gel method is carried out by heat treatment in a vacuum furnace at more than the degas temperature and less than the baking temperature, wherein the highest temperature in the helium atmosphere is preferably set to from more than 700° C. to less than 1400° C., and the helium atmosphere is kept to less than 400° C.

    摘要翻译： 本发明提供可以使石英玻璃制品在熔融时几乎不具有气泡的合成石英粉末的改性方法，以及使用所述改性石英粉末的合成石英粉末和玻璃制品的改性方法， 至少在降温过程中，将合成石英粉保存在氦气氛中，当通过溶胶 - 凝胶法制造的无定形合成石英粉末在真空炉中通过在脱气温度下进行热处理并且小于 烘烤温度，其中氦气氛中的最高温度优选设定为大于700℃至小于1400℃，氦气保持在小于400℃。

    Power control apparatus
    4.
    发明授权
    Power control apparatus 失效
    电源控制装置

    公开(公告)号：US06756549B2

    公开(公告)日：2004-06-29

    申请号：US10164590

    申请日：2002-06-10

    申请人： Mika Suzuki ,  Takayoshi Endo ,  Hironori Kondo ,  Goro Nakamura ,  Norihiro Ohashi ,  Takahiro Satoh

    发明人： Mika Suzuki ,  Takayoshi Endo ,  Hironori Kondo ,  Goro Nakamura ,  Norihiro Ohashi ,  Takahiro Satoh

    IPC分类号： H01H1900

    CPC分类号： H01H19/566 ,  H01H1/2041 ,  H01H1/365 ,  H01H3/26 ,  H01H9/38

    摘要： A rotating terminal (16) has a circumferential outer peripheral surface (21a, 24a) having its center disposed at an axis (13, 21b) of rotation of the rotating terminal, and has electrically conductive areas and non-electrically conductive areas alternately arranged on the outer peripheral surface in the circumferential direction. At least one pair of fixed terminals (17, 18) are fixed and disposed outwardly of a path of rotation of the outer peripheral surface of the rotating terminal. In accordance with a rotating position of the rotating terminal, the pair of fixed terminals can be switched between an electrically-conducting condition, in which the pair of fixed terminals are electrically connected together through the rotating terminal, and an interrupting condition in which the pair of fixed terminals are not electrically connected together through the rotating terminal.

    摘要翻译： 旋转端子（16）具有周向外周面（21a，24a），其中心设置在旋转端子的旋转轴线（13,21b）上，并且具有交替布置在其上的导电区域和非导电区域 外周面在圆周方向上。 至少一对固定端子（17,18）固定并设置在旋转端子的外周面的旋转路径的外侧。 根据旋转端子的旋转位置，一对固定端子可以在一对固定端子通过旋转端子电连接在一起的导电状态之间切换，并且其中该对 的固定端子不通过旋转端子电连接在一起。

    Push-in type fuse
    5.
    发明授权
    Push-in type fuse 失效
    推入式保险丝

    公开(公告)号：US06529113B2

    公开(公告)日：2003-03-04

    申请号：US09849973

    申请日：2001-05-08

    申请人： Takayoshi Endo ,  Hiroki Kondo ,  Goro Nakamura ,  Norihiro Ohashi ,  Takahiro Satoh

    发明人： Takayoshi Endo ,  Hiroki Kondo ,  Goro Nakamura ,  Norihiro Ohashi ,  Takahiro Satoh

    IPC分类号： H01H85153

    CPC分类号： H01H85/0417

    摘要： A presser spring (43) is separately formed with a fuse body (33), and therefore may be formed of a material having a high spring characteristic. The presser spring (43) is attached to a portion of peripheral wall portions (41b) to which a back plate portion (41a) is opposed, so that a mating tab terminal (39), inserted in an engagement space (45), is pressed against the back plate portion (41a) by the presser spring (43).

    摘要翻译： 压脚弹簧（43）分别形成有熔断体（33），因此可以由具有高弹簧特性的材料形成。 压脚弹簧（43）安装在背板部（41a）相对的周壁部（41b）的一部分上，使插入接合空间（45）的配合翼片端子（39）为 通过压脚弹簧（43）压靠背板部（41a）。