公开(公告)号：US20080311571A1

公开(公告)日：2008-12-18

申请号：US11791041

申请日：2005-11-21

申请人： Hiroshi Jikihara ,  Shintaro Kawai ,  Takanori Oka

发明人： Hiroshi Jikihara ,  Shintaro Kawai ,  Takanori Oka

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C12Q1/6876 ,  C12Q1/6881 ,  C12Q2525/161 ,  C12Q2600/156

摘要： A nucleic acid fragment set according to the present invention comprises a plural number of nucleic acid fragments capable of individually hybridizing with a plural number of target sequences, in which each nucleic acid fragment has a region ligatable with each other and the affinity between such ligatable regions is adjusted to a higher level than the affinity between the target sequence and the nucleic acid fragment. The nucleic acid fragment according to the present invention is for use in a nucleic acid fragment kit. The nucleic acid fragment of the present invention can be used as a probe for detecting nucleic acid or a competitor for detecting nucleic acid. According to the present invention, human leukocyte antigen (HLA) genes, T-cell receptor genes, red blood cell group determining genes, and Rh antigen genes, and the like can be detected at a high accuracy level.

摘要翻译： 根据本发明的核酸片段包含能够与多个靶序列单独杂交的多个核酸片段，其中每个核酸片段具有彼此可连接的区域，并且该可连接区域之间的亲合力 被调节到比靶序列和核酸片段之间的亲和力更高的水平。 根据本发明的核酸片段用于核酸片段试剂盒。 本发明的核酸片段可用作检测核酸的探针或用于检测核酸的竞争者。 根据本发明，可以以高精度水平检测人白细胞抗原（HLA）基因，T细胞受体基因，红细胞群决定基因和Rh抗原基因等。

公开(公告)号：US07424260B2

公开(公告)日：2008-09-09

申请号：US11281914

申请日：2005-11-16

申请人： Ryuji Nishiyama ,  Shintaro Kawai

发明人： Ryuji Nishiyama ,  Shintaro Kawai

IPC分类号： G03G15/20

CPC分类号： G03G15/2042

摘要： The contact rate between a heater 1 and a heater holder 2 is made higher at both ends in the longitudinal direction of the heater than at the center. Alternatively, the per-unit-length volume of the heater holder 2 in the longitudinal direction is made larger at the both ends in the longitudinal direction of the heater. In this configuration, the heat generated by the heater can easily escape into the heater holder side at the both ends but cannot easily escape into the heater holder side at the center. Although the per-unit-length heat amount in the longitudinal direction of the heater may be even, it is also possible to set the heat amount distribution in such a way that the heat amount at the both ends is larger than that at the center. The present invention prevents an improper fixing problem generated by an insufficient temperature at a particular position of a recording material and, at the same time, prevents an increase in the temperature of the non-paper-passage part that occurs when a narrow recording material is used.

摘要翻译： 加热器1和加热器支架2之间的接触率在加热器的纵向方向的两端比在中心处更高。 或者，加热器保持件2在长度方向上的每单位长度的体积在加热器的纵向方向上的两端处较大。 在这种结构中，加热器产生的热量可以容易地逸出到两端的加热器保持器侧，但是不能容易地逸出到中心的加热器支架侧。 尽管加热器的纵向方向上的每单位长度的热量可以是均匀的，但是也可以设定热量分布，使得两端的热量大于中心的热量分布。 本发明防止由于在记录材料的特定位置处的温度不足而产生的不正确的固定问题，并且同时防止当狭窄的记录材料是非纸张通道部分时出现的非纸通道部分的温度升高 用过的。

公开(公告)号：US20060153605A1

公开(公告)日：2006-07-13

申请号：US11281914

申请日：2005-11-16

申请人： Ryuji Nishiyama ,  Shintaro Kawai

发明人： Ryuji Nishiyama ,  Shintaro Kawai

IPC分类号： G03G15/20

CPC分类号： G03G15/2042

摘要： The contact rate between a heater 1 and a heater holder 2 is made higher at both ends in the longitudinal direction of the heater than at the center. Alternatively, the per-unit-length volume of the heater holder 2 in the longitudinal direction is made larger at the both ends in the longitudinal direction of the heater. In this configuration, the heat generated by the heater can easily escape into the heater holder side at the both ends but cannot easily escape into the heater holder side at the center. Although the per-unit-length heat amount in the longitudinal direction of the heater may be even, it is also possible to set the heat amount distribution in such a way that the heat amount at the both ends is larger than that at the center. The present invention prevents an improper fixing problem generated by an insufficient temperature at a particular position of a recording material and, at the same time, prevents an increase in the temperature of the non-paper-passage part that occurs when a narrow recording material is used.

摘要翻译： 加热器1和加热器支架2之间的接触率在加热器的纵向方向的两端比在中心处更高。 或者，加热器保持件2在长度方向上的每单位长度的体积在加热器的纵向方向上的两端处较大。 在这种结构中，加热器产生的热量可以容易地逸出到两端的加热器保持器侧，但是不能容易地逸出到中心的加热器支架侧。 尽管加热器的纵向方向上的每单位长度的热量可以是均匀的，但是也可以设定热量分布，使得两端的热量大于中心的热量分布。 本发明防止由于在记录材料的特定位置处的温度不足而产生的不正确的固定问题，并且同时防止当狭窄的记录材料是非纸张通道部分时出现的非纸通道部分的温度升高 用过的。

公开(公告)号：US5939542A

公开(公告)日：1999-08-17

申请号：US931072

申请日：1997-09-15

申请人： Shintaro Kawai ,  Shinji Maekawajiri ,  Hirotaka Nakamoto

发明人： Shintaro Kawai ,  Shinji Maekawajiri ,  Hirotaka Nakamoto

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6881

摘要： A probe set is provided which can assay larger amounts of samples in a simpler manner and enables typing of all HLA-DR types currently known to be present in Japanese. The probe set comprises part or all of oligonucleotides having the following sequences 1 to 16 or complementary strands thereof:sequence 1: CGGTTGCTCGGAAAGATGCATCsequence 2: ACACTCCCTCTTTGGCTGsequence 3: GGCCGGGTGGACAACTACsequence 4: ATGTTTAACCTGCTCCAAsequence 5: CCTGATGAGGAGTACTGGAAsequence 6: AGCTACTGCGCTTCGACsequence 7: CGTAGAGTACTCCAAGAAsequence 8: CTTATACTTACCCTGCCAsequence 9: AGACAGGCGGGCCCTsequence 10: TCAAACTTATCCTGCTTCsequence 11: AAACTTAACCTCCTCCAAsequence 12: ACTCTACGTCTGAGTGTCsequence 13: ACGGGTGAGTGTTATTTCsequence 14: GACCTCCTGGAAGACAGGsequence 15: ACATCCTGGAAGACGAGCsequence 16: CCCGTAGTTGTGTCTGCA.

摘要翻译： 提供了一种探针组，其可以以更简单的方式测定更大量的样品，并且能够打印目前已知以日语存在的所有HLA-DR类型。 探针组包含具有以下序列1至16或其互补链的部分或全部寡核苷酸：序列1：CGGTTGCTCGGAAAGATGCATC序列2：ACACTCCCTCTTTGGCTG序列3：GGCCGGGTGGACAACTAC序列4：ATGTTTAACCTGCTCCAA序列5：CCTGATGAGGAGTACTGGAA序列6：AGCTACTGCGCTTCGAC序列7：CGTAGAGTACTCCAAGAA序列 8：CTTATACTTACCCTGCCA序列9：AGACAGGCGGGCCCT序列10：TCAAACTTATCCTGCTTC序列11：AAACTTAACCTCCTCCAA序列12：ACTCTACGTCTGAGTGTC序列13：ACGGGTGAGTGTTATTTC序列14：GACCTCCTGGAAGACAGG序列15：ACATCCTGGAAGACGAGC序列16：CCCGTAGTTGTGTCTGCA。