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47 条记录 (耗时 0.025 秒)

    Dioxolobenzizoxazole derivatives
    1.
    发明授权
    Dioxolobenzizoxazole derivatives 失效
    二氧代苯并恶唑衍生物

    公开(公告)号：US4732906A

    公开(公告)日：1988-03-22

    申请号：US840680

    申请日：1986-03-18

    申请人： Hiroshi Koga ,  Takashi Dan ,  Haruhiko Sato ,  Etsuro Onuma

    发明人： Hiroshi Koga ,  Takashi Dan ,  Haruhiko Sato ,  Etsuro Onuma

    IPC分类号： A61K31/357 ,  A61K31/42 ,  A61P7/10 ,  C07D261/00 ,  C07D317/00 ,  C07D498/04 ,  C07D261/20

    CPC分类号： C07D498/04

    摘要： Dioxolobenzisoxazole derivatives of the formula ##STR1## wherein R.sub.1 is a phenyl group which may be substituted with a halogen atom, a lower alkyl group having 1-3 carbon atoms or a lower haloalkyl group, or a thienyl group; R.sub.2 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and X and Y which may be the same or different represent a hydrogen atom or a halogen atom, as well as non-toxic salts thereof wherein R.sub.2 is a hydrogen atom, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.The derivatives have diuretic and uricosuric activities and, therefore, are useful as a drug for treating hyperuricemia or hypertension.

    摘要翻译： 其中R 1是可以被卤素原子取代的苯基，具有1-3个碳原子的低级烷基或低级卤代烷基，或噻吩基的式Ⅱ的二氧代联苯并恶唑衍生物; R2是氢原子或具有1-4个碳原子的低级烷基; 和可以相同或不同的X和Y表示氢原子或卤素原子，以及其中R2是氢原子的无毒盐，其制备方法和含有它们的药物组合物 。 衍生物具有利尿和尿酸活性，因此可用作治疗高尿酸血症或高血压的药物。

    Furobenzisoxazole derivatives
    2.
    发明授权
    Furobenzisoxazole derivatives 失效
    呋喃苯并恶唑衍生物

    公开(公告)号：US4791209A

    公开(公告)日：1988-12-13

    申请号：US860210

    申请日：1986-05-06

    申请人： Haruhiko Sato ,  Hiroshi Koga ,  Takashi Dan ,  Etsuro Onuma

    发明人： Haruhiko Sato ,  Hiroshi Koga ,  Takashi Dan ,  Etsuro Onuma

    IPC分类号： C07D498/04 ,  A61K31/42

    CPC分类号： C07D498/04

    摘要： Novel furobenzisoxazole derivatives of the formula (I): ##STR1## (wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 which may be the same or different represent a hydrogen atom, a halogen atom, or a lower alkyl group having 1-4 carbon atoms; R.sub.5 is a hydroxymethyl group, a carboxyl group or a lower alkoxy carbonyl group having 1-3 carbon atoms; and X is a sulfur atom or a --CH.dbd.CH-- group), as well as intoxic salts thereof when R.sub.5 is a carboxyl group, and process for preparing the same are disclosed.The derivatives of formula (I) and nontoxic salts thereof have hypotensive, uricosuric and diuretic activities and hence ae useful as therapeutics for treating hyperuricemia, edema and hypertension.

    摘要翻译： 式（I）的新型呋喃苯并异恶唑衍生物：其中R 1，R 2，R 3和R 4可以相同或不同，表示氢原子，卤素原子或具有1-4个碳原子的低级烷基 碳原子; R5是羟基甲基，羧基或具有1-3个碳原子的低级烷氧基羰基; X是硫原子或-CH = CH-基团），以及当其为R5时的中性盐 羧基，及其制备方法。 式（I）的衍生物及其无毒盐具有降血压，尿酸和利尿活性，因此可用作治疗高尿酸血症，水肿和高血压的治疗剂。

    N-(2-cyanoethyl)-6-fluoroalkyl-2h-1-benzopyran derivatives
    5.
    发明授权
    N-(2-cyanoethyl)-6-fluoroalkyl-2h-1-benzopyran derivatives 失效
    N-（2-氰基乙基）-6-氟烷基-2h -1-苯并吡喃衍生物

    公开(公告)号：US5646310A

    公开(公告)日：1997-07-08

    申请号：US448576

    申请日：1995-06-07

    申请人： Hiroshi Koga ,  Haruhiko Sato ,  Takenori Ishizawa

    发明人： Hiroshi Koga ,  Haruhiko Sato ,  Takenori Ishizawa

    IPC分类号： C07D311/58 ,  A61K31/35

    CPC分类号： C07D311/58

    摘要： Described herein are benzopyran derivatives represented by the formula: ##STR1## wherein R, X and Y represent any of the following combinations:______________________________________ R X Y ______________________________________ C.sub.2 F.sub.5 O H C.sub.2 F.sub.5 S H CF.sub.3 S F C.sub.2 F.sub.5 S F C.sub.3 F.sub.7 S F ______________________________________ and pharmaceutically acceptable salts thereof. These compounds have an excellent potassium channel activity and are also excellent from the aspect of safety.

    摘要翻译： PCT No.PCT / JP94 / 00682 Sec。 371日期：1995年6月7日 102（e）日期1995年6月7日PCT 1994年4月25日PCT PCT。 第WO94 / 25021号公报 日期：1994年11月10日描述的是下式表示的苯并吡喃衍生物：其中R，X和Y表示以下组合中的任何一种： - RXY - C2F5 OH - C2F5 SH - CF3 SF - C2F5 SF - C3F7 SF-及其药学上可接受的盐。 这些化合物具有优异的钾通道活性，并且从安全性方面也是优异的。

    Benzopyran derivatives
    6.
    发明授权
    Benzopyran derivatives 失效
    苯并吡喃衍生物

    公开(公告)号：US5614633A

    公开(公告)日：1997-03-25

    申请号：US387745

    申请日：1995-02-17

    申请人： Hiroshi Koga ,  Haruhiko Sato ,  Takenori Ishizawa ,  Hiroyuki Nabata

    发明人： Hiroshi Koga ,  Haruhiko Sato ,  Takenori Ishizawa ,  Hiroyuki Nabata

    IPC分类号： C07D311/22 ,  C07D311/68 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04 ,  G07D405/04

    CPC分类号： C07D405/04 ,  C07D311/22 ,  C07D311/68 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04

    摘要： Novel benzopyran and benzoxazine derivatives represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.

    摘要翻译： PCT No.PCT / JP93 / 01150 Sec。 371日期：1995年2月17日 102（e）日期1995年2月17日PCT 1995年3月15日PCT公布。 第WO94 / 04521号公报 日期1993年3月3日由以下通式表示的新型苯并吡喃和苯并恶嗪衍生物：其中R1和R2表示低级卤代烷基，R3表示氢原子等，R4表示杂环基或AO-，其中A表示 环状结构等，R5和R6表示低级卤代烷基，X表示= N-，N-→O等。 这些化合物显示K +通道开启活化，可广泛用作抗哮喘药，抗癫痫药等。

    Furoxanthone derivatives useful as diuretics
    7.
    发明授权
    Furoxanthone derivatives useful as diuretics 失效
    呋喃西酮衍生物可用作利尿剂

    公开(公告)号：US4661607A

    公开(公告)日：1987-04-28

    申请号：US775240

    申请日：1985-09-12

    申请人： Hiroshi Koga ,  Takashi Mori ,  Takashi Dan ,  Michitaka Akima

    发明人： Hiroshi Koga ,  Takashi Mori ,  Takashi Dan ,  Michitaka Akima

    IPC分类号： A61K31/35 ,  C07D311/86 ,  C07D493/04

    CPC分类号： C07D493/04 ,  C07D311/86 ,  Y10S514/869

    摘要： Xanthone derivatives of the formula (I): ##STR1## (wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is hydrogen atom or together with Z forms a --CH.sub.2 -- group which binds to a phenyl carbon adjacent the phenyl carbon to which the oxygen of the group ##STR2## is attached to form a cyclic methylene chain; B is a hydroxymethyl group, a lower alkoxycarbonyl group having 1 to 4 carbon atoms, or a carboxyl group, provided that W is neither a hydrogen atom nor a 7-position methyl group when X, Y and Z are each a hydrogen atom, and A is a hydrogen atom and B is a carboxyl group or a lower alkoxycarbonyl group), as well as non-toxic salts thereof when B is a carboxyl group, and a process for preparing the same are disclosed.The compounds of formula (I) in accordance with the present invention are useful as diuretics having uricosuric activity and can be used in the treatment of edema or hypertension.

    摘要翻译： 式（I）的呫吨酮衍生物：其中W，X，Y和Z可以相同或不同，表示氢原子，卤素原子或碳原子数1〜4的低级烷基 ; A是氢原子或与Z一起形成-CH 2 - 基团，其结合与苯基碳相邻的苯基碳，所述基团的氧连接到其上以形成环状亚甲基链; B是羟甲基， 具有1至4个碳原子的低级烷氧基羰基或羧基，条件是当X，Y和Z各自为氢原子时，W既不是氢原子也不是7-位甲基，A为氢原子， B为羧基或低级烷氧基羰基），以及B为羧基时的无毒性盐，以及其制备方法。 根据本发明的式（I）化合物可用作具有尿酸活性的利尿剂，并且可用于治疗水肿或高血压。

    Xanthone derivatives and process for producing the same
    8.
    发明授权
    Xanthone derivatives and process for producing the same 失效
    呫吨衍生物及其制备方法

    公开(公告)号：US4816479A

    公开(公告)日：1989-03-28

    申请号：US937101

    申请日：1986-12-02

    申请人： Hiroshi Koga ,  Takashi Mori ,  Takashi Dan ,  Michitaka Akima

    发明人： Hiroshi Koga ,  Takashi Mori ,  Takashi Dan ,  Michitaka Akima

    IPC分类号： A61K31/35 ,  C07D311/86 ,  C07D493/04

    CPC分类号： C07D493/04 ,  C07D311/86 ,  Y10S514/869

    摘要： Xanthone derivatives of the formula (I): ##STR1## wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is a hydrogen atom B is a hydroxymethyl group, a lower alkoxycarbonyl group having 1 to 4 carbon atoms, or a carboxyl group, provided that a --O--CH.sub.2 --B group is bonded to the 2- or 3-position of the xanthone ring and that there is no case in which X, Y, and Z are each a hydrogen atom concurrently; as well as intoxic salts thereof when B is a carboxyl group, and a process for preparing the same are disclosed.The compounds of formula (I) in accordance with the present invention are useful as diuretics having uricosuric activity and can be used in the treatment of edema or hypertension.

    Automatic authentication method and system in print process
    9.
    发明授权
    Automatic authentication method and system in print process 有权

    公开(公告)号：US08522026B2

    公开(公告)日：2013-08-27

    申请号：US11842931

    申请日：2007-08-21

    申请人： Hiroshi Koga

    发明人： Hiroshi Koga

    IPC分类号： G06F21/00

    CPC分类号： G06F21/608

    摘要： This invention provides an automatic authentication method and system in a print process, which can obviate the need for user's input operations of the user ID and password and can improve security since authentication is automatically done based on print information embedded in a file or information from an application program without any user's input.In a print process that requires user authentication, a printer driver extracts information related to an application and/or a document for the print process as attribute information, and user authentication is made by comparing the attribute information with information stored in a user registration information database of a server. If user authentication has succeeded, the printer driver controls a printer to print, and the server manages and stores accounting information and the like for respective departments in a department management information database.