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公开(公告)号：US09526408B2
公开(公告)日：2016-12-27
申请号：US13446721
申请日：2012-04-13
申请人： Hiroshi Yamaguchi , Takaaki Saito , Takayuki Iida
发明人： Hiroshi Yamaguchi , Takaaki Saito , Takayuki Iida
IPC分类号： A61B5/1459 , A61B1/045 , A61B1/06 , A61B1/00
CPC分类号： A61B1/0638 , A61B1/00004 , A61B1/045 , A61B1/063 , A61B1/0653
摘要： A light source device of an electronic endoscope system has first and second semiconductor lasers. In a vascular observation mode, one of the semiconductor lasers is used in a full light state (100% rated output) while the other is used in a reduced light state (for example, 10% rated output). First and second images of an internal body portion are captured with a color imaging device under illumination of two patterns, respectively. Correlation operation of pixel values of three colors is performed between the two images. Noise components, caused by the first or second semiconductor lasers in the light reduced state, are removed from the first and second images. An oxygen saturation level of blood in a blood vessel is calculated using the first and second images with the noise components removed.
摘要翻译： 电子内窥镜系统的光源装置具有第一和第二半导体激光器。 在血管观察模式中，其中一个半导体激光器在全光照状态（100％额定输出）下使用，另一个在减光条件下使用（例如，10％额定输出）。 分别在两个图案的照明下用彩色成像装置捕获内部主体部分的第一和第二图像。 在两个图像之间执行三种颜色的像素值的相关操作。 由第一或第二半导体激光器引起的光衰减状态引起的噪声分量从第一和第二图像中去除。 使用去除了噪声成分的第一和第二图像来计算血管中血液的氧饱和度水平。
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公开(公告)号：US10265004B2
公开(公告)日：2019-04-23
申请号：US13533882
申请日：2012-06-26
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： A61B5/1459 , A61B5/1455 , A61B1/06 , A61B1/04 , A61B5/00
摘要： In a blood information measuring apparatus, a plurality of types of light of a superficial layer wavelength set, a middle layer wavelength set, and a deep layer wavelength set are successively applied to a detected hypoxic region. A CCD captures an image under the light of each wavelength set, and an oxygen saturation image is produced independently from one wavelength set to another. A wavelength set determination section creates a histogram of each oxygen saturation image. The wavelength set determination section chooses one of the wavelength sets corresponding to the histogram having a maximum variance as an actual imaging wavelength set. Actual imaging operation is performed using the actual imaging wavelength set, and an oxygen saturation level of each pixel is calculated. The oxygen saturation level is reflected in the image, and the image is displayed on a monitor.
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公开(公告)号：US20120253157A1
公开(公告)日：2012-10-04
申请号：US13434924
申请日：2012-03-30
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B1/0638 , A61B1/0646 , A61B5/065 , A61B5/1459 , G06F19/00
摘要： In a special mode, a superficial wavelength set having plural types of narrow band light in a blue wavelength band of 400 to 500 nm is chosen. The plural types of narrow band light are successively applied to an internal body portion. A CCD captures images of the internal body portion under the narrow band light. A blood information calculation section calculates an oxygen saturation level of hemoglobin in a blood vessel based on an image signal. A comparison section compares the calculated oxygen saturation level with a predetermined threshold value. When the oxygen saturation level is less than the threshold value, a hypoxic region detection signal is outputted to a wavelength set switching section. The wavelength set switching section switches from the superficial wavelength set to a middle wavelength set and to a deep wavelength set, so the oxygen saturation levels at middle and deep depths are measured.
摘要翻译： 在特殊模式中，选择具有400〜500nm的蓝色波段的多种类型的窄带光的浅表波长组。 多个类型的窄带光被连续施加到内部主体部分。 CCD在窄带光下拍摄内部主体部分的图像。 血液信息计算部根据图像信号计算血管中血红蛋白的氧饱和度水平。 比较部分将计算的氧饱和度水平与预定阈值进行比较。 当氧饱和度低于阈值时，将低氧区域检测信号输出到波长设定切换部。 波长设置切换部分从表面波长集合切换到中间波长集合到深波长集合，从而测量中深度和深深处的氧饱和度水平。
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公开(公告)号：US09014772B2
公开(公告)日：2015-04-21
申请号：US13434924
申请日：2012-03-30
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： A61B5/1455 , A61B1/06 , A61B5/06 , A61B5/1459
CPC分类号： A61B5/14551 , A61B1/0638 , A61B1/0646 , A61B5/065 , A61B5/1459 , G06F19/00
摘要： In a special mode, a superficial wavelength set having plural types of narrow band light in a blue wavelength band of 400 to 500 nm is chosen. The plural types of narrow band light are successively applied to an internal body portion. A CCD captures images of the internal body portion under the narrow band light. A blood information calculation section calculates an oxygen saturation level of hemoglobin in a blood vessel based on an image signal. A comparison section compares the calculated oxygen saturation level with a predetermined threshold value. When the oxygen saturation level is less than the threshold value, a hypoxic region detection signal is outputted to a wavelength set switching section. The wavelength set switching section switches from the superficial wavelength set to a middle wavelength set and to a deep wavelength set, so the oxygen saturation levels at middle and deep depths are measured.
摘要翻译： 在特殊模式中，选择具有400〜500nm的蓝色波段的多种类型的窄带光的浅表波长组。 多个类型的窄带光被连续施加到内部主体部分。 CCD在窄带光下拍摄内部主体部分的图像。 血液信息计算部根据图像信号计算血管中血红蛋白的氧饱和度水平。 比较部分将计算的氧饱和度水平与预定阈值进行比较。 当氧饱和度低于阈值时，将低氧区域检测信号输出到波长设定切换部。 波长设置切换部分从表面波长集合切换到中间波长集合到深波长集合，从而测量中深度和深深处的氧饱和度水平。
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公开(公告)号：US09044163B2
公开(公告)日：2015-06-02
申请号：US13306135
申请日：2011-11-29
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： H04N7/18 , A61B5/1455 , A61B5/1459 , A61B1/00 , A61B1/06
CPC分类号： A61B1/0653 , A61B1/00009 , A61B1/063 , A61B1/0638 , A61B5/14551 , A61B5/1459
摘要： The endoscope apparatus includes an illumination unit for irradiating at least three kinds of illumination light having different wavelengths including standard light, first and second reference light onto a biological object, a switching unit for periodically switching the illumination light, an imaging unit for capturing image data by the illumination light in each imaging frame, and an acquisition unit for acquiring biological function information from the captured image data. The irradiation order of illumination light is switched at least in order of the first reference light, the standard light and the second reference light, a standard image by the standard light and reference images by the reference light are acquired, and the biological function information is calculated based on the standard image and the reference images.
摘要翻译： 所述内窥镜装置包括照射单元，用于将具有标准光，第一和第二参考光的不同波长的至少三种照明光照射到生物体上，用于周期性地切换照明光的切换单元，用于捕获图像数据的成像单元 通过每个成像帧中的照明光，以及用于从捕获的图像数据获取生物功能信息的获取单元。 照射光的照射次序至少按照第一参考光，标准光和第二参照光的顺序切换，通过标准光进行标准图像，并且获取参考光的参考图像，生物学功能信息是 基于标准图像和参考图像计算。
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公开(公告)号：US20130053703A1
公开(公告)日：2013-02-28
申请号：US13562059
申请日：2012-07-30
CPC分类号： A61B1/0638 , A61B1/00006 , A61B1/00009 , A61B1/043 , A61B1/05 , A61B1/063 , A61B1/0653
摘要： An endoscopic diagnosis system includes a light source unit for emitting green and red light, blue and green light, or white light and excitation light having different central wavelengths for causing an autofluorescent substance to emit autofluorescence, an imaging unit for receiving reflected light from the observation region to acquire a reflected light image when the observation region is illuminated with the illumination light emitted, and receiving autofluorescence that is emitted from the autofluorescent substance, absorbed by blood, and decreases according to the amount of the blood to acquire an autofluorescence image when the observation region is irradiated with the excitation light emitted, and an image correction unit for correcting the autofluorescence image based on the reflected light image.
摘要翻译： 内窥镜诊断系统包括用于发射绿色和红色光，蓝色和绿色光的光源单元或具有不同中心波长的白光和激发光，用于使自发荧光物质发射自发荧光;成像单元，用于接收来自观察的反射光 区域，当观察区域被发射的照明光照射时获取反射光图像，并且接收从自发荧光物质发射的自发荧光，被血液吸收的自发荧光，并且当根据血液的量减少以获得自发荧光图像，当获得自发荧光图像时 用发射的激发光照射观察区域，以及图像校正单元，用于基于反射光图像校正自发荧光图像。
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公开(公告)号：US20130018242A1
公开(公告)日：2013-01-17
申请号：US13533882
申请日：2012-06-26
申请人： Hiroshi YAMAGUCHI , Takaaki Saito
发明人： Hiroshi YAMAGUCHI , Takaaki Saito
IPC分类号： A61B5/1459
CPC分类号： A61B5/14551 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0037 , A61B5/0084 , A61B5/1459 , A61B5/489
摘要： In a blood information measuring apparatus, a plurality of types of light of a superficial layer wavelength set, a middle layer wavelength set, and a deep layer wavelength set are successively applied to a detected hypoxic region. A CCD captures an image under the light of each wavelength set, and an oxygen saturation image is produced independently from one wavelength set to another. A wavelength set determination section creates a histogram of each oxygen saturation image. The wavelength set determination section chooses one of the wavelength sets corresponding to the histogram having a maximum variance as an actual imaging wavelength set. Actual imaging operation is performed using the actual imaging wavelength set, and an oxygen saturation level of each pixel is calculated. The oxygen saturation level is reflected in the image, and the image is displayed on a monitor.
摘要翻译： 在血液信息测量装置中，对检测到的缺氧区域依次应用表面层波长集合，中间层波长集合和深层波长集合的多种类型的光。 CCD在每个波长集合的光下拍摄图像，并且独立地从一个波长设置到另一个波长产生氧饱和度图像。 波长组确定部分创建每个氧饱和度图像的直方图。 波长组确定部选择与具有最大方差的直方图对应的波长集合中的一个作为实际成像波长组。 使用实际成像波长设置来执行实际成像操作，并且计算每个像素的氧饱和度水平。 氧饱和度水平反映在图像中，图像显示在监视器上。
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公开(公告)号：US20120253158A1
公开(公告)日：2012-10-04
申请号：US13436179
申请日：2012-03-30
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： A61B5/1455 , A61B1/06 , A61B6/00 , A61B5/145
CPC分类号： A61B5/1459 , A61B1/0638 , A61B1/0646 , A61B5/065 , A61B5/14551 , G06F19/00
摘要： In a special mode, a superficial layer wavelength set, a middle layer wavelength set, and a deep layer wavelength set are selected successively. Each wavelength set is composed of 3 different types of narrowband light applied successively to an internal body portion. A wavelength set table specifies the number of repetitions of each wavelength set. A controller controls a wavelength band switching element to apply every type of the narrowband light of each wavelength set, and to apply each wavelength set for the number of repetitions specified by the wavelength set table. A CCD captures images of the internal body portion under illumination of the narrowband light of the respective wavelength sets. A blood information calculation section calculates oxygen saturation levels of hemoglobin in blood vessels in the superficial, middle, and deep layers based on image signals, respectively. This provides information on cancer progression.
摘要翻译： 在特殊模式中，依次选择表面层波长集合，中间层波长集合和深层波长集合。 每个波长组由连续施加到内部主体部分的3种不同类型的窄带光构成。 波长集表指定每个波长集合的重复次数。 控制器控制波长带开关元件以应用每种波长集合的每种类型的窄带光，并且对波长设置表指定的重复次数应用每个波长集合。 CCD在相应波长组的窄带光照射下捕获内部主体部分的图像。 血液信息计算部分基于图像信号计算表层，中层和深层血管中血红蛋白的氧饱和度水平。 这提供了癌症进展的信息。
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公开(公告)号：US08996087B2
公开(公告)日：2015-03-31
申请号：US13436179
申请日：2012-03-30
申请人： Hiroshi Yamaguchi , Takaaki Saito
发明人： Hiroshi Yamaguchi , Takaaki Saito
IPC分类号： A61B5/1455 , A61B5/1459 , A61B1/06 , A61B5/06
CPC分类号： A61B5/1459 , A61B1/0638 , A61B1/0646 , A61B5/065 , A61B5/14551 , G06F19/00
摘要： In a special mode, a superficial layer wavelength set, a middle layer wavelength set, and a deep layer wavelength set are selected successively. Each wavelength set is composed of 3 different types of narrowband light applied successively to an internal body portion. A wavelength set table specifies the number of repetitions of each wavelength set. A controller controls a wavelength band switching element to apply every type of the narrowband light of each wavelength set, and to apply each wavelength set for the number of repetitions specified by the wavelength set table. A CCD captures images of the internal body portion under illumination of the narrowband light of the respective wavelength sets. A blood information calculation section calculates oxygen saturation levels of hemoglobin in blood vessels in the superficial, middle, and deep layers based on image signals, respectively. This provides information on cancer progression.
摘要翻译： 在特殊模式中，依次选择表面层波长集合，中间层波长集合和深层波长集合。 每个波长组由连续施加到内部主体部分的3种不同类型的窄带光构成。 波长集表指定每个波长集合的重复次数。 控制器控制波长带开关元件以施加每种波长组的每种类型的窄带光，并且对波长设置表指定的重复次数应用每个波长集合。 CCD在相应波长组的窄带光照射下捕获内部主体部分的图像。 血液信息计算部分基于图像信号计算表层，中层和深层血管中血红蛋白的氧饱和度水平。 这提供了癌症进展的信息。
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公开(公告)号：US20130041218A1
公开(公告)日：2013-02-14
申请号：US13562149
申请日：2012-07-30
CPC分类号： A61B1/0638 , A61B1/00006 , A61B1/00009 , A61B1/00045 , A61B1/04 , A61B1/063 , A61B1/0653 , A61B1/0661 , A61B5/489 , A61B5/7257
摘要： An endoscopic device that irradiates a plurality of illuminating light having different spectrums from each other onto a subject at a front edge of an endoscope inserting module and captures the subject to obtain an observation image The endoscopic device includes an illuminating module, an imaging module, a light intensity ratio control module, and a color tone correcting module. The illuminating module generates the plurality of illuminating light. The imaging module captures the subject and output an image signal of the observation image. The light intensity ratio control module controls the illuminating module to irradiate the plurality of illuminating light onto the subject with a set light intensity ratio by setting the light intensity ratio of the plurality of illuminating light. The color tone correcting module corrects the color tone to obtain the observation image with substantially the same color tone even though the light intensity ratio is changed.
摘要翻译： 一种内窥镜装置，其将具有不同光谱的多个照明光照射到内窥镜插入模块的前端的被检体上并捕捉被检体以获得观察图像。内窥镜装置包括照明模块，摄像模块， 光强比控制模块和色调校正模块。 照明模块生成多个照明光。 成像模块捕获被摄体并输出观察图像的图像信号。 光强度控制模块通过设定多个照明光的光强度比例，控制照明模块以设定的光强度比将多个照明光照射到被摄体上。 色调校正模块校正色调以获得具有基本上相同色调的观察图像，即使光强比改变。
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