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    Method for diagnosing malignant tumor
    1.
    发明授权
    Method for diagnosing malignant tumor 有权
    诊断恶性肿瘤的方法

    公开(公告)号：US09097714B2

    公开(公告)日：2015-08-04

    申请号：US13512903

    申请日：2010-12-15

    申请人： Hiroyuki Ebinuma ,  Kohei Takubo ,  Masanao Matsuo ,  Isamu Fukamachi ,  Hideaki Bujo ,  Chiaki Nakaseko ,  Yasushi Saito

    发明人： Hiroyuki Ebinuma ,  Kohei Takubo ,  Masanao Matsuo ,  Isamu Fukamachi ,  Hideaki Bujo ,  Chiaki Nakaseko ,  Yasushi Saito

    IPC分类号： G01N33/574 ,  G01N21/64 ,  G01N21/47 ,  G01N21/76 ,  G01N33/92

    CPC分类号： G01N33/574 ,  G01N33/57426 ,  G01N33/92 ,  G01N2800/52 ,  G01N2800/54

    摘要： To provide a method and a diagnostic kit for determining the presence of a malignant tumor or the severity thereof, a method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or a method for estimating the risk of recurrence of the malignant tumor or determining the presence or absence of the recurrence.The method for determining the presence of a malignant tumor or the severity thereof, method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or method for estimating the risk of recurrence of the malignant tumor or the presence or absence of the recurrence is characterized by including 1) a step of measuring the concentration and/or quantity of soluble LR11 in a sample originating from a subject and 2) a step of comparing the value measured above with a measurement value of soluble LR11 obtained from a healthy subject group.

    摘要翻译： 为了提供用于确定恶性肿瘤的存在或其严重性的方法和诊断试剂盒，选择其治疗方法或评价治疗方法的效果的方法或估计恶性肿瘤复发风险的方法 确定复发的存在或不存在。 用于确定恶性肿瘤的存在或其严重性的方法，用于选择其治疗方法或评估治疗方法的效果的方法，或用于估计恶性肿瘤复发风险的方法或是否存在恶性肿瘤 复发的特征在于包括1）测量源自受试者的样品中可溶性LR11的浓度和/或量的步骤，以及2）将上述测定值与从健康受试者获得的可溶性LR11的测定值进行比较的步骤 组。

    METHOD FOR DIAGNOSING MALIGNANT TUMOR
    2.
    发明申请
    METHOD FOR DIAGNOSING MALIGNANT TUMOR 有权
    诊断恶性肿瘤的方法

    公开(公告)号：US20130029363A1

    公开(公告)日：2013-01-31

    申请号：US13512903

    申请日：2010-12-15

    申请人： Hiroyuki Ebinuma ,  Kohei Takubo ,  Masanao Matsuo ,  Isamu Fukamachi ,  Hideaki Bujo ,  Chiaki Nakaseko ,  Yasushi Saito

    发明人： Hiroyuki Ebinuma ,  Kohei Takubo ,  Masanao Matsuo ,  Isamu Fukamachi ,  Hideaki Bujo ,  Chiaki Nakaseko ,  Yasushi Saito

    IPC分类号： G01N33/574 ,  G01N21/64 ,  G01N21/47 ,  G01N21/76

    CPC分类号： G01N33/574 ,  G01N33/57426 ,  G01N33/92 ,  G01N2800/52 ,  G01N2800/54

    摘要： To provide a method and a diagnostic kit for determining the presence of a malignant tumor or the severity thereof, a method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or a method for estimating the risk of recurrence of the malignant tumor or determining the presence or absence of the recurrence.The method for determining the presence of a malignant tumor or the severity thereof, method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or method for estimating the risk of recurrence of the malignant tumor or the presence or absence of the recurrence is characterized by including 1) a step of measuring the concentration and/or quantity of soluble LR11 in a sample originating from a subject and 2) a step of comparing the value measured above with a measurement value of soluble LR11 obtained from a healthy subject group.

    摘要翻译： 为了提供用于确定恶性肿瘤的存在或其严重性的方法和诊断试剂盒，选择其治疗方法或评价治疗方法的效果的方法或估计恶性肿瘤复发风险的方法 确定复发的存在或不存在。 用于确定恶性肿瘤的存在或其严重性的方法，用于选择其治疗方法或评估治疗方法的效果的方法，或用于估计恶性肿瘤复发风险的方法或是否存在恶性肿瘤 复发的特征在于包括1）测量源自受试者的样品中可溶性LR11的浓度和/或量的步骤，以及2）将上述测定值与从健康受试者获得的可溶性LR11的测定值进行比较的步骤 组。

    METHOD FOR IMMUNOLOGICALLY MEASURING SOLUBLE LR11
    5.
    发明申请
    METHOD FOR IMMUNOLOGICALLY MEASURING SOLUBLE LR11 有权
    免疫测定方法LR11

    公开(公告)号：US20140080158A1

    公开(公告)日：2014-03-20

    申请号：US14116683

    申请日：2012-05-09

    申请人： Kohei Takubo ,  Hiroyuki Ebinuma ,  Isamu Fukamachi ,  Hideaki Bujo ,  Yasushi Saito

    发明人： Kohei Takubo ,  Hiroyuki Ebinuma ,  Isamu Fukamachi ,  Hideaki Bujo ,  Yasushi Saito

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/92

    摘要： To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample).The method of the invention for immunologically assaying soluble LR11 present in a biological sample, characterized in that the method includes treating the sample with at least one surfactant selected from among one or more sulfobetaine amphoteric surfactants and one or more amidosulfobetaine amphoteric surfactants.

    摘要翻译： 为了提供用于测定生物样品中可溶性LR11的方法，该方法通过免疫学手段实现了样品中存在的可溶性LR11的简单且准确的测定，而不需要从生物样品（例如血清样品）分离可溶性LR11。 用于免疫测定存在于生物样品中的可溶性LR11的本发明的方法，其特征在于所述方法包括用选自一种或多种磺基甜菜碱两性表面活性剂和一种或多种氨基磺基甜菜碱两性表面活性剂中的至少一种表面活性剂处理样品。

    Method for immunologically measuring soluble LR11
    6.
    发明授权
    Method for immunologically measuring soluble LR11 有权
    免疫测定可溶性LR11的方法

    公开(公告)号：US09541550B2

    公开(公告)日：2017-01-10

    申请号：US14116683

    申请日：2012-05-09

    申请人： Kohei Takubo ,  Hiroyuki Ebinuma ,  Isamu Fukamachi ,  Hideaki Bujo ,  Yasushi Saito

    发明人： Kohei Takubo ,  Hiroyuki Ebinuma ,  Isamu Fukamachi ,  Hideaki Bujo ,  Yasushi Saito

    IPC分类号： G01N33/543 ,  G01N33/92

    CPC分类号： G01N33/54393 ,  G01N33/92

    摘要： To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample).The method of the invention for immunologically assaying soluble LR11 present in a biological sample, characterized in that the method includes treating the sample with at least one surfactant selected from among one or more sulfobetaine amphoteric surfactants and one or more amidosulfobetaine amphoteric surfactants.

    摘要翻译： 用于免疫测定存在于生物样品中的可溶性LR11的本发明的方法，其特征在于所述方法包括用选自一种或多种磺基甜菜碱两性表面活性剂和一种或多种氨基磺基甜菜碱两性表面活性剂中的至少一种表面活性剂处理样品。

    METHOD FOR PRE-TREATING SAMPLE CONTAINING GLYCATED HEMOGLOBIN
    8.
    发明申请
    METHOD FOR PRE-TREATING SAMPLE CONTAINING GLYCATED HEMOGLOBIN 有权
    用于预处理含有糖化血红蛋白的样品的方法

    公开(公告)号：US20110318765A1

    公开(公告)日：2011-12-29

    申请号：US13139239

    申请日：2009-12-10

    申请人： Osamu Miyazaki ,  Syunsuke Kurashita ,  Kohei Takubo

    发明人： Osamu Miyazaki ,  Syunsuke Kurashita ,  Kohei Takubo

    IPC分类号： G01N33/72 ,  G01N1/00 ,  C07K14/805

    CPC分类号： G01N33/723 ,  G01N2400/02 ,  G01N2440/38

    摘要： There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time; and an method for an immunological assay of glycated hemoglobin using this technique.A method for pre-treating a glycated hemoglobin-containing sample for an immunological assay of glycated hemoglobin, the method includes treating a glycated hemoglobin-containing sample with a pre-treatment solution containing (A) guanidine or a salt thereof and (B) a nonionic surfactant and/or a nitrite.

    摘要翻译： 提供了含有糖化血红蛋白的样品的预处理技术，其是简单且方便的处理，在储存稳定性和环境方面没有问题，并且能够在短时间内充分暴露表位; 以及使用该技术的糖化血红蛋白的免疫测定方法。 一种用于对糖化血红蛋白的免疫学测定进行预处理的糖化血红蛋白样品的方法，所述方法包括用含有（A）胍或其盐的预处理溶液处理含糖血红蛋白的样品，和（B） 非离子表面活性剂和/或亚硝酸盐。

    Method for pre-treating sample containing glycated hemoglobin
    9.
    发明授权
    Method for pre-treating sample containing glycated hemoglobin 有权
    预处理含有糖化血红蛋白的样品的方法

    公开(公告)号：US09341633B2

    公开(公告)日：2016-05-17

    申请号：US13139239

    申请日：2009-12-10

    申请人： Osamu Miyazaki ,  Syunsuke Kurashita ,  Kohei Takubo

    发明人： Osamu Miyazaki ,  Syunsuke Kurashita ,  Kohei Takubo

    IPC分类号： G01N33/72

    CPC分类号： G01N33/723 ,  G01N2400/02 ,  G01N2440/38

    摘要： There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time; and an method for an immunological assay of glycated hemoglobin using this technique.A method for pre-treating a glycated hemoglobin-containing sample for an immunological assay of glycated hemoglobin, the method includes treating a glycated hemoglobin-containing sample with a pre-treatment solution containing (A) guanidine or a salt thereof and (B) a nonionic surfactant and/or a nitrite.

    摘要翻译： 提供了含有糖化血红蛋白的样品的预处理技术，其是简单且方便的处理，在储存稳定性和环境方面没有问题，并且能够在短时间内充分暴露表位; 以及使用该技术的糖化血红蛋白的免疫测定方法。 一种用于对糖化血红蛋白的免疫学测定进行预处理的糖化血红蛋白样品的方法，所述方法包括用含有（A）胍或其盐的预处理溶液处理含糖血红蛋白的样品，和（B） 非离子表面活性剂和/或亚硝酸盐。