公开(公告)号：US20070269377A1

公开(公告)日：2007-11-22

申请号：US11663962

申请日：2005-09-28

申请人： Hiroyuki Oku ,  Kazuto Omi ,  Kaisuke Kuriyama ,  Jyunya Yamamoto ,  Keiichi Yamada ,  Ryoichi Katakai ,  Kumiko Sato ,  Mamoru Suzuki ,  Shin-ichiro Kawazu ,  Shigeyuki Kano

发明人： Hiroyuki Oku ,  Kazuto Omi ,  Kaisuke Kuriyama ,  Jyunya Yamamoto ,  Keiichi Yamada ,  Ryoichi Katakai ,  Kumiko Sato ,  Mamoru Suzuki ,  Shin-ichiro Kawazu ,  Shigeyuki Kano

IPC分类号： A61K39/015 ,  A61K49/00 ,  A61P33/06 ,  C07K1/10 ,  G01N33/569

CPC分类号： G01N33/56905 ,  A61K39/00 ,  C07K14/445 ,  C12N9/88 ,  Y02A50/412

摘要： F The peptide production method of the present invention produces a peptide (SEQ ID NO: 1) of a protein from Plasmodium falciparum, which is effective as a malaria vaccine. The method produces the peptide of SEQ ID NO: 1 by linking the fragments (i) through (v) shown below: (v)Asn-Asn-Asp-Xaa;(SEQ ID NO: 2) (iv)Asp-Phe-Lys-Thr-Pro;(SEQ ID NO: 3) (iii)Asn-Lys-Thr-Tyr-Asp-Leu;(SEQ ID NO: 4) (ii)Phe-Tyr-Asn-Ser-Glu;(SEQ ID NO: 5) and (i)Xaa-Ala-Ser-Glu,(SEQ ID NO: 6) where ‘Xaa’ in (i) and (v) represents zero or any arbitrary number of amino acid residues.

公开(公告)号：US07713926B2

公开(公告)日：2010-05-11

申请号：US11663962

申请日：2005-09-28

申请人： Hiroyuki Oku ,  Kazuto Omi ,  Keisuke Kuriyama ,  Jyunya Yamamoto ,  Keiichi Yamada ,  Ryoichi Katakai ,  Kumiko Sato ,  Mamoru Suzuki ,  Shin-ichiro Kawazu ,  Shigeyuki Kano

发明人： Hiroyuki Oku ,  Kazuto Omi ,  Keisuke Kuriyama ,  Jyunya Yamamoto ,  Keiichi Yamada ,  Ryoichi Katakai ,  Kumiko Sato ,  Mamoru Suzuki ,  Shin-ichiro Kawazu ,  Shigeyuki Kano

IPC分类号： A61K38/00 ,  C07K1/00

CPC分类号： G01N33/56905 ,  A61K39/00 ,  C07K14/445 ,  C12N9/88 ,  Y02A50/412

摘要： The peptide production method of the present invention produces a peptide (SEQ ID NO: 1) of a protein from Plasmodium falciparum, which is effective as a malaria vaccine. The method produces the peptide of SEQ ID NO: 1 by linking the fragments (i) through (v) shown below: (v) Asn-Asn-Asp-Xaa (SEQ ID NO: 2); (iv) Asp-Phe-Lys-Thr-Pro (SEQ ID NO: 3); (iii) Asn-Lys-Thr-Tyr-Asp-Leu (SEQ ID NO: 4); (ii) Phe-Tyr-Asn-Ser-Glu (SEQ ID NO: 5); and (i) Xaa-Ala-Ser-Glu (SEQ ID NO: 6), where ‘Xaa’ in (i) and (v) represents zero or any arbitrary number of amino acid residues.

摘要翻译： 本发明的肽生产方法产生作为疟疾疫苗有效的来自恶性疟原虫的蛋白质的肽（SEQ ID NO：1）。 该方法通过连接如下所示的片段（i）至（v）产生SEQ ID NO：1的肽：（v）Asn-Asn-Asp-Xaa（SEQ ID NO：2）; （iv）Asp-Phe-Lys-Thr-Pro（SEQ ID NO：3）; （iii）Asn-Lys-Thr-Tyr-Asp-Leu（SEQ ID NO：4）; （ii）Phe-Tyr-Asn-Ser-Glu（SEQ ID NO：5）; 和（i）Xaa-Ala-Ser-Glu（SEQ ID NO：6），其中（i）和（v）中的“Xaa”表示0或任意数目的氨基酸残基。

公开(公告)号：US10583184B2

公开(公告)日：2020-03-10

申请号：US15531122

申请日：2015-11-27

申请人： Shigeyuki Kano

发明人： Hiroyuki Oku ,  Shigeyuki Kano ,  Kazuhiko Yano

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/015 ,  C12N9/88 ,  G01N33/53 ,  A61K38/00 ,  C07K14/445 ,  A61K47/64 ,  A61K9/16 ,  G01N33/543 ,  G01N33/569 ,  G01N33/68

摘要： The invention provides a bioactive peptide including a partial amino acid sequence of Plasmodium falciparum enolase, and having a molecular structure compatible with a specification setting for a GMP-compliant production process. The peptide has a structure in which two peptides, each having an amino acid sequence of A01-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-A02 (SEQ ID NO: 1) or A03-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-Lys-Ser-Leu-Val-Lys-Thr-A04 (SEQ ID NO: 2) are linked by amide bonds between the respective carboxy termini of the two peptides and two amino groups of Lys in a linker peptide represented by Lys-A05-Cys-A06 and arranged in the form of a two-forked branch, wherein each of A01 to A06 represents an amino acid residue in a number of an arbitrary number including 0. The peptide preferably has a dimerized structure in which two of the above described peptides are linked by an S—S bond between the Cys residues in the linker peptide sequences included in the respective two peptides.