公开(公告)号：US07379572B2

公开(公告)日：2008-05-27

申请号：US10270674

申请日：2002-10-16

申请人： Hiroyuki Yoshida ,  Abraham Dachman ,  Janne Nappi ,  Peter Maceneaney ,  David Rubin ,  Yoshitaka Masutani ,  Li Lan

发明人： Hiroyuki Yoshida ,  Abraham Dachman ,  Janne Nappi ,  Peter Maceneaney ,  David Rubin ,  Yoshitaka Masutani ,  Li Lan

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T7/41 ,  G06T2207/10081 ,  G06T2207/30032

摘要： A method, system, and computer program product for identifying at least one three-dimensionally extended lesion within a volumetric region encompassing an inner surface, an outer surface, and intervening tissue of a target organ. The method includes: (1) generating a set of voxels representing a total scanned volume from a set of cross-sectional images of the target organ; (2) performing segmentation to extract a set of voxels representing the volumetric region from the set of voxels representing the total scanned volume; (3) detecting a set of candidate lesions based on geometric feature values of each voxel in the set of voxels representing the volumetric region; and (4) selecting the at least one three-dimensionally extended lesion from the set of candidate lesions based on at least one of volumetric, morphologic, and texture feature values of each lesion in the set of candidate lesions.

摘要翻译： 一种用于识别包围目标器官的内表面，外表面和中间组织的体积区域内的至少一个三维延伸的病变的方法，系统和计算机程序产品。 该方法包括：（1）从目标器官的一组横截面图像生成代表总扫描体积的一组体素; （2）执行分割以从表示总扫描体积的体素组提取表示体积区域的一组体素; （3）基于代表体积区域的体素集合中的每个体素的几何特征值来检测候选病变组; 以及（4）基于所述候选病变组中的每个病变的体积，形态和纹理特征值中的至少一个，从所述候选病变组中选择所述至少一个三维延伸的病变。

公开(公告)号：US4327074A

公开(公告)日：1982-04-27

申请号：US011619

申请日：1979-02-12

申请人： David Rubin ,  David Rubin

发明人： David Rubin ,  David Rubin

IPC分类号： A61K51/04 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/50 ,  A61K49/00 ,  A61K43/00

CPC分类号： A61K51/0491 ,  A61K31/7004 ,  A61K47/48092 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/5091 ,  A61K2123/00 ,  C12Q2334/00 ,  G01N2333/924

摘要： Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or is water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention. A urine test is disclosed to determine the amount of free glucuronic acid in the urine which is an indication of the presence of a tumor in the body having high .beta.-glucuronidase activity.

摘要翻译： 具有高β-葡糖醛酸糖苷酶活性的高酸化肿瘤可以用具有对肿瘤细胞有毒性的糖苷配基的葡糖苷酸处理，其对身体的其余部分具有极大的安全性，首先以足以将非肿瘤组织的pH水平维持在足量的碱性剂 葡萄糖苷酸处理期间约7.4。 这将导致身体其余部分的β-葡萄糖醛酸酶活性失活。 公开了新的葡糖苷酸，其在酸性环境中发挥较高的毒性作用或仅在碱性环境中是水溶性的糖苷配基。 这些化合物具有上述方法的特殊用途。 通过用放射性同位素代替糖苷配基，可以进行诊断和原位放射治疗。 具有β-葡糖苷酸酶活性的细菌细胞也可以根据本发明进行诊断和治疗。 公开了尿液测试以确定尿液中游离葡萄糖醛酸的量，其表示具有高β-葡萄糖醛酸酶活性的体内肿瘤的存在。

公开(公告)号：US20110104328A1

公开(公告)日：2011-05-05

申请号：US12986952

申请日：2011-01-07

申请人： David Rubin ,  Ely Rubin ,  Tal Rubin

发明人： David Rubin ,  Ely Rubin ,  Tal Rubin

IPC分类号： C12G1/022 ,  C12G1/02

CPC分类号： C12G1/02 ,  A23G3/364 ,  A23G3/48 ,  A23G4/068 ,  A23G4/12 ,  A23K1/1612 ,  A23K20/111 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/006 ,  A61K9/0095 ,  A61K31/047 ,  A61K31/09 ,  C12G2200/21 ,  C12H1/14

摘要： Resveratrol and/or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi, as well as to deliver resveratrol to an animal. The resveratrol and/or pterostilbene are also added to red wine to preserve the polyphenols present in red wine. The resveratrol and/or pterostilbene can be added to grape must prior to fermentation and/or to fermented wine prior to bottling.

摘要翻译： 将白藜芦醇和/或蝶啶二烯加入到葡萄酒中以保护葡萄酒免于氧化，细菌和真菌，并将白藜芦醇递送至动物。 白藜芦醇和/或or芪烯也加入到红葡萄酒中以保存红葡萄酒中存在的多酚。 在发酵前可以将白藜芦醇和/或蝶啶二苯乙烯加入到葡萄中，和/或在装瓶之前将葡萄酒发酵。

公开(公告)号：US07442818B2

公开(公告)日：2008-10-28

申请号：US11373994

申请日：2006-03-14

申请人： David Rubin ,  Eyal Rubin

发明人： David Rubin ,  Eyal Rubin

IPC分类号： C11C1/00

CPC分类号： C07C67/03 ,  C07C69/52 ,  C07C69/24

摘要： Esters of organic acids are produced by a transesterification reaction by reacting a first ester with an alcohol to form a second ester in the presence of a catalyst comprising a mixture of DCC and DMAP.

摘要翻译： 有机酸的酯通过酯交换反应通过使第一酯与醇反应以在含有DCC和DMAP的混合物的催化剂存在下形成第二酯而产生。

公开(公告)号：US07153989B2

公开(公告)日：2006-12-26

申请号：US11053891

申请日：2005-02-10

申请人： David Rubin ,  Eyal Rubin

发明人： David Rubin ,  Eyal Rubin

IPC分类号： C11B3/00

CPC分类号： C07C51/353 ,  C07C57/12

摘要： Trans-9,cis-11-octadecadienoic acid is produced by forming a urea inclusion complex with cis-linoleic acid, treating the complex with a catalytic amount of a base, and recovering the trans-9,cis-11 octadecadienoic acid. Tans-10,cis-12-octadecadienoic acid is produced by iodinating cis-linoleic acid at temperatures of about −5–20° C. A mixture of trans-9,cis-11 octadecadienoic acid and trans-10,cis-12-octadecadienoic acid comprising is produced by iodinating cis-linoleic acid at temperatures ranging from about 50 to about 90° C.

摘要翻译： 反式9，顺式-11-十八碳二烯酸通过与顺式亚油酸形成尿素包合配合物，用催化量的碱处理该配合物，并回收反式9，顺式-11-十八碳二烯酸来制备。 通过在约-5-20℃的温度下碘化顺式亚油酸生产Tans-10，顺式-12-十八碳二烯酸。反式-9，顺式-11-十八碳二烯酸和反式-10-顺式-12-十八碳二烯酸的混合物， 包含的十八碳二烯酸通过在约50至约90℃的温度范围内碘化顺式亚油酸产生。

公开(公告)号：US20060178521A1

公开(公告)日：2006-08-10

申请号：US11053891

申请日：2005-02-10

申请人： David Rubin ,  Eyal Rubin

发明人： David Rubin ,  Eyal Rubin

IPC分类号： C07C51/347

CPC分类号： C07C51/353 ,  C07C57/12

摘要： Trans-9,cis-11-octadecadienoic acid is produced by forming a urea inclusion complex with cis-linoleic acid, treating the complex with a catalytic amount of a base, and recovering the trans-9,cis-11 octadecadienoic acid. Tans-10,cis-12-octadecadienoic acid is produced by iodinating cis-linoleic acid at temperatures of about −5-20° C. A mixture of trans-9,cis-11 octadecadienoic acid and trans-10,cis-12-octadecadienoic acid comprising is produced by iodinating cis-linoleic acid at temperatures ranging from about 50 to about 90° C.

公开(公告)号：US20050122916A1

公开(公告)日：2005-06-09

申请号：US11040673

申请日：2005-01-21

申请人： David Rubin ,  Anthony Kolodzinski

发明人： David Rubin ,  Anthony Kolodzinski

IPC分类号： H04M3/22 ,  H04M3/30 ,  H04B3/36

CPC分类号： H04M3/30 ,  H04M3/2209 ,  H04M3/305

摘要： The invention provides a system and method for testing a telephone or communications line to determine if the line qualifies for a particular type or class of communications service, for example DSL service. In accordance with one embodiment, a potential customer can download a software program. The program first performs a DSL distance qualification calculation. If the customer' line passes this step, the program determines whether the line coupled between the customer and a central office servicing that customer is electrically qualified for DSL communications. A series of tests to measure signal levels, noise, and other characteristics are performed by a test server, which generally include local loop tests to determine the presence of bridged taps, load coils, and subscriber line concentrators. After the tests are completed, the customer can receive the results, order completion and other instructions.

摘要翻译： 本发明提供一种用于测试电话或通信线路以确定线路是否符合特定类型或类别的通信服务（例如DSL服务）的系统和方法。 根据一个实施例，潜在顾客可以下载软件程序。 该程序首先执行DSL距离限定计算。 如果客户线通过此步骤，该程序将确定客户与为该客户提供服务的中心局之间的线路是否符合DSL通信的电气条件。 用于测量信号电平，噪声和其他特性的一系列测试由测试服务器执行，测试服务器通常包括本地环路测试以确定桥接抽头，负载线圈和用户线集线器的存在。 测试完成后，客户可以收到结果，订单完成和其他说明。

公开(公告)号：US06846942B2

公开(公告)日：2005-01-25

申请号：US10441266

申请日：2003-05-20

申请人： David Rubin

发明人： David Rubin

IPC分类号： C07C51/487 ,  C11C1/00 ,  C11C1/08 ,  C11B7/00

CPC分类号： C11C1/08 ,  C07C51/487 ,  C11C1/005 ,  C07C57/03

摘要： Pure DHA and pure EPA can be obtained from a mixture of EPA and DHA in a solution by forming salts of DHA and EPA which have different solubilities in the solvent, cooling the solution until the salt of EPA is formed, filtering the solution to recover the salt of EPA, and acidifying the EPA salt and the DHA salt to obtain pure EPA and pure DHA.

摘要翻译： 纯DHA和纯EPA可以通过在溶液中通过形成具有不同溶解度的DHA和EPA的盐形式从EPA和DHA的混合物中获得，冷却溶液直到形成EPA盐，过滤溶液以回收 EPA的盐，并酸化EPA盐和DHA盐以获得纯EPA和纯DHA。

公开(公告)号：US06407071B1

公开(公告)日：2002-06-18

申请号：US09694679

申请日：2000-10-24

申请人： David Rubin

发明人： David Rubin

IPC分类号： A61K3170

CPC分类号： A61K45/06 ,  A61K31/70 ,  A61K2300/00

摘要： A composition for treating tumors comprising a combination of at least one oxidizing agent and at least one aldehyde or precursor thereof, which aldehyde forms an insoluble thiazoline with cysteine. Optionally a compound which inhibits glutathione-s-transferase is included.

摘要翻译： 一种用于治疗肿瘤的组合物，其包含至少一种氧化剂和至少一种醛或其前体的组合，所述醛与半胱氨酸形成不溶性噻唑啉。 包括抑制谷胱甘肽-S-转移酶的化合物。

公开(公告)号：US5059603A

公开(公告)日：1991-10-22

申请号：US364289

申请日：1989-06-12

申请人： David Rubin

发明人： David Rubin

IPC分类号： A61K9/00 ,  A61K31/52

CPC分类号： A61K9/0034 ,  A61K31/52 ,  Y10S514/947

摘要： A composition for treating impotence contains a vasodilator, a vasoconstrictor, and a penetration enhancing ingredient in a pharmaceutically acceptable carrier for topical application. The composition is applied topically to treat impotence.

摘要翻译： 用于治疗阳A的组合物在用于局部应用的药学上可接受的载体中含有血管扩张剂，血管收缩剂和渗透促进成分。 组合物局部施用以治疗阳。。