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1.发明申请T-butoxycarbonylaminoethylamine for the Synthesis of PNA Monomer Units, Amino Acid Derivatives, Intermediates Thereof, and Processes for Productions of Them 审中-公开用于合成PNA单体单元，氨基酸衍生物及其中间体的叔丁氧基羰基氨基乙胺及其制备方法公开(公告)号：US20080167491A1
公开(公告)日：2008-07-10
申请号：US12028622
申请日：2008-02-08
申请人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
发明人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
IPC分类号： C07C227/02
CPC分类号： C07C255/60 , B01D15/362 , B01J39/04 , B01J39/26 , C07C235/38 , C07C269/06 , C07C271/20 , C07K1/062
摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
摘要翻译： 由下列通式（I）表示的氨基酸衍生物的方法：（其中R 1表示氢原子或具有1-5个碳原子的直链或支链烷基），其具有 目的是提供式（I）的氨基酸衍生物及其合成中间体叔丁氧基羰基氨基 - 乙胺的方法，其不需要繁琐的程序，产率也良好，并且其在批量生产中的应用容易， 并提供式（IV）的新型氨基酸衍生物及其合成中间体及其方法，其特征在于，其包括通过水解所述通式（I）所示化合物的方法获得通式（I）所示的氨基酸衍生物的步骤 下式（II）：其中R 1具有与上述相同的含义，R 2表示具有1-4个碳原子的直链或支链烷基 原子）以及由通式（IV）表示的氨基酸衍生物：（其中R
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2.发明申请T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them 失效用于合成PNA单体单元的叔丁氧基羰基氨基乙胺，氨基酸衍生物，其中间体及其制备方法公开(公告)号：US20050187402A1
公开(公告)日：2005-08-25
申请号：US11111022
申请日：2005-04-21
申请人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
发明人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
IPC分类号： B01D15/36 , B01J39/04 , B01J39/26 , C07C235/38 , C07C255/60 , C07C269/06 , C07C271/20 , C07K1/06 , C07C271/02
CPC分类号： C07C255/60 , B01D15/362 , B01J39/04 , B01J39/26 , C07C235/38 , C07C269/06 , C07C271/20 , C07K1/062
摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
摘要翻译： 由下列通式（I）表示的氨基酸衍生物的方法：（其中R 1表示氢原子或具有1-5个碳原子的直链或支链烷基），其具有 目的是提供式（I）的氨基酸衍生物及其合成中间体叔丁氧基羰基氨基 - 乙胺的方法，其不需要繁琐的程序，产率也良好，其在批量生产中的应用容易， 并提供式（IV）的新型氨基酸衍生物及其合成中间体及其方法，其特征在于，其包括通过水解所述通式（I）所示化合物的方法获得通式（I）所示的氨基酸衍生物的步骤 下式（II）：其中R 1具有与上述相同的含义，R 2表示具有1-4个碳原子的直链或支链烷基 原子）以及由通式（IV）表示的氨基酸衍生物：（其中R
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3.发明授权T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them 失效用于合成PNA单体单元的叔丁氧基羰基氨基乙胺，氨基酸衍生物，中间体及其制备方法公开(公告)号：US07351852B2
公开(公告)日：2008-04-01
申请号：US11111022
申请日：2005-04-21
申请人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
发明人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
IPC分类号： C07C261/00
CPC分类号： C07C255/60 , B01D15/362 , B01J39/04 , B01J39/26 , C07C235/38 , C07C269/06 , C07C271/20 , C07K1/062
摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
摘要翻译： 由下列通式（I）表示的氨基酸衍生物的方法：（其中R 1表示氢原子或具有1-5个碳原子的直链或支链烷基），其具有 目的是提供式（I）的氨基酸衍生物及其合成中间体叔丁氧基羰基氨基 - 乙胺的方法，其不需要繁琐的程序，产率也良好，并且其在批量生产中的应用容易， 并提供式（IV）的新型氨基酸衍生物及其合成中间体及其方法，其特征在于，其包括通过水解所述通式（I）所示化合物的方法获得通式（I）所示的氨基酸衍生物的步骤 下式（II）：其中R 1具有与上述相同的含义，R 2表示具有1-4个碳原子的直链或支链烷基 原子）以及由通式（IV）表示的氨基酸衍生物：（其中R
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公开(公告)号：US06919476B2
公开(公告)日：2005-07-19
申请号：US10398621
申请日：2001-09-05
申请人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
发明人： Hisafumi Ikeda , Isao Saito , Yushin Nakamura
IPC分类号： B01D15/36 , B01J39/04 , B01J39/26 , C07C235/38 , C07C255/60 , C07C269/06 , C07C271/20 , C07K1/06 , C07C261/00
CPC分类号： C07C255/60 , B01D15/362 , B01J39/04 , B01J39/26 , C07C235/38 , C07C269/06 , C07C271/20 , C07K1/062
摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
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