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    METHOD FOR MANUFACTURING A 6-SUBSTITUTED 1-METHYL-1H-BENZIMIDAZOLE DERIVATIVE AND AN INTERMEDIATE OF SAID METHOD
    2.
    发明申请
    METHOD FOR MANUFACTURING A 6-SUBSTITUTED 1-METHYL-1H-BENZIMIDAZOLE DERIVATIVE AND AN INTERMEDIATE OF SAID METHOD 审中-公开
    制备6-取代的1-甲基-1H-苯并咪唑衍生物的方法和所述方法的中间体

    公开(公告)号：US20120238759A1

    公开(公告)日：2012-09-20

    申请号：US13511190

    申请日：2010-11-25

    申请人： Yutaka Ikeuchi ,  Chiharu Satoh ,  Eiji Numagami ,  Satoru Nihei ,  Hisaki Kajino

    发明人： Yutaka Ikeuchi ,  Chiharu Satoh ,  Eiji Numagami ,  Satoru Nihei ,  Hisaki Kajino

    IPC分类号： C07D417/12 ,  C07C217/90 ,  C07C213/02 ,  C07D277/34

    CPC分类号： C07C213/02 ,  A61K31/427 ,  C07C217/90 ,  C07D277/34 ,  C07D417/12 ,  Y02P20/55

    摘要： A method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative represented by the formula (IV) wherein R3 represents a hydrogen atom or a C1-C4 alkyl group. A 4-substituted N2-methylbenzene-1,2-diamine derivative is prepared from a particular 5-substituted N-methyl-2-nitroaniline derivative, subsequently reacting the resulting compound with {4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy}acetic acid or an acid chloride or a mixed acid anhydride thereof, and subsequently subjecting the resulting compound to intramolecular dehydration condensation. A compound of the formula (II) wherein R1 represents a hydrogen atom, a C1-C4 alkyl group, or a protective group for the nitrogen atom, and R2 represents a hydrogen atom or a protective group for the nitrogen atom is prepared and used as an intermediate.

    摘要翻译： 制备由式（IV）表示的6-取代的1-甲基-1H-苯并咪唑衍生物的方法，其中R 3表示氢原子或C 1 -C 4烷基。 4-取代的N-甲基苯-1,2-二胺衍生物由特定的5-取代的N-甲基-2-硝基苯胺衍生物制备，随后将得到的化合物与{4 - [（2,4-二氧代-1,2-二氢 - 3-噻唑烷-5-基）甲基]苯氧基}乙酸或其酰氯或其混合酸酐，然后将所得化合物进行分子内脱水缩合。 制备式（II）化合物，其中R1表示氢原子，C1-C4烷基或氮原子的保护基，R2表示氢原子或氮原子的保护基，并用作 一个中间人

    Crystalline forms of thiazolidinedione compound and its manufacturing method
    5.
    发明申请
    Crystalline forms of thiazolidinedione compound and its manufacturing method 失效
    噻唑烷二酮化合物的结晶形式及其制备方法

    公开(公告)号：US20110046388A1

    公开(公告)日：2011-02-24

    申请号：US12311610

    申请日：2008-02-08

    申请人： Hisaki Kajino ,  Yutaka Ikeuchi ,  Hiroshi Miyamoto ,  Eiji Numagami ,  Satoru Nihei

    发明人： Hisaki Kajino ,  Yutaka Ikeuchi ,  Hiroshi Miyamoto ,  Eiji Numagami ,  Satoru Nihei

    IPC分类号： C07D417/12

    CPC分类号： C07D417/12

    摘要： It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I). [Formula 1]

    摘要翻译： 本发明的目的是提供作为制备过氧化物酶体增殖物激活受体（PPAR）活化剂和抗癌药物组合物的药物成分的噻唑烷二酮化合物的结晶形式。 本发明涉及5-（4 - {[6-（4-氨基-3,5-二甲基苯氧基）-1-甲基-1H苯并咪唑-2-基]甲氧基}苄基） -1,3-噻唑烷-2,4-二酮盐酸盐，由下式（I）表示。 [公式1]

    Coriolis mass flowmeter
    7.
    发明授权
    Coriolis mass flowmeter 有权
    科里奥利质量流量计

    公开(公告)号：US06895826B1

    公开(公告)日：2005-05-24

    申请号：US09485017

    申请日：1999-05-28

    申请人： Yuichi Nakao ,  Yasuichi Shiraishi ,  Satoru Nihei ,  Seiji Kobayashi ,  Yasushi Ito

    发明人： Yuichi Nakao ,  Yasuichi Shiraishi ,  Satoru Nihei ,  Seiji Kobayashi ,  Yasushi Ito

    IPC分类号： G01F1/84

    CPC分类号： G01F1/8409 ,  G01F1/8418 ,  G01F1/8422 ,  G01F1/8427 ,  G01F1/8477

    摘要： The Coriolis mass flow meter of this invention comprises two parallel curved flow tubes 1 and 2, a drive unit 15, and a pair of vibration sensors 16 and 17. An inlet-side manifold 24 dividing the flow of a fluid being measured into the two flow tubes 1 and 2 from the inlet thereof, and an outlet-side manifold 25 joining the fluid flows flowing in the two flow tubes 1 and 2 to discharge from the fluid outlet thereof are mechanically connected to a meter body 30 only at the inlet side of the inlet-side manifold 24 and at the outlet side of the outlet-side manifold 25, respectively. With this arrangement, the effects of vibration transmitted from the meter body 30 and all structures connected thereto can be reduced at the joint parts between the inlet-side and outlet-side manifolds 24 and 25 that serve as vibration fulcrums.

    摘要翻译： 本发明的科里奥利质量流量计包括两个平行的弯曲流管1和2，一个驱动单元15和一对振动传感器16和17.一个入口侧歧管24将被测流体的流动分为两个 从其入口流出流量管1和2，并且连接流过两个流管1和2的流体的出口侧歧管25从其流体出口排出，仅在入口侧机械地连接到仪表主体30 的入口侧歧管24和出口侧歧管25的出口侧。 通过这种布置，在用作振动支点的入口侧歧管24和出口侧歧管25之间的接合部处，可以减少从仪表主体30传递的振动和与其连接的所有结构的影响。