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公开(公告)号:US5238938A
公开(公告)日:1993-08-24
申请号:US857726
申请日:1992-03-26
申请人: Hitoshi Tone , Seiji Sato , Hideaki Sato , Katsumi Tamura , Shigeharu Tamada , Kazumi Kondo , Tomoyuki Kawaguchi , Yoshimasa Nakano , Yasuyuki Kita , Shuji Akai , Hiromichi Fujioka , Yasumitsu Tamura , Katsuhide Matoba , Youichi Taniguchi , Shinji Nishitani , Satoshi Hayakawa , Toshinori Kaneyasu , Yoshihiko Ito , Masahiro Murakami
发明人: Hitoshi Tone , Seiji Sato , Hideaki Sato , Katsumi Tamura , Shigeharu Tamada , Kazumi Kondo , Tomoyuki Kawaguchi , Yoshimasa Nakano , Yasuyuki Kita , Shuji Akai , Hiromichi Fujioka , Yasumitsu Tamura , Katsuhide Matoba , Youichi Taniguchi , Shinji Nishitani , Satoshi Hayakawa , Toshinori Kaneyasu , Yoshihiko Ito , Masahiro Murakami
IPC分类号: C07D403/04 , C07D403/06
CPC分类号: C07D403/04 , C07D403/06
摘要: The novel indole derivatives and salts thereof represented by the general formula (1) ##STR1## possess, for example, an inhibitory effect against superoxide (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation and an anti-albuminuria activity against Masugi nephritis, and are useful in various clinical fields as an agent for preventing and treating diseases and cases associated with the above superoxide radical, for example, autoimmune diseases (e.g. rheumatism), arteriosclerosis, ischemic disease, ischemic encephalopathia, hepatic insufficiency and renal insufficiency, and also as an agent for preventing and treating nephritis.
摘要翻译: 由通式(1)表示的新的吲哚衍生物及其盐具有例如通过刺激和抗白蛋白尿对豚鼠巨噬细胞释放的对超氧化物(O 2 - )的抑制作用 针对Masugi肾炎的活性,并且在各种临床领域中用作预防和治疗与上述超氧化物基团相关的疾病和病例的药剂,例如自身免疫性疾病(例如风湿病),动脉硬化,缺血性疾病,缺血性脑病,肝功能不全和 肾功能不全,还可用作预防和治疗肾炎的药剂。