公开(公告)号：US5832177A

公开(公告)日：1998-11-03

申请号：US426185

申请日：1995-04-21

申请人： Keisuke Shinagawa ,  Shuzo Fujimura ,  Yuuji Matoba ,  Yoshimasa Nakano ,  Tatsuya Takeuchi ,  Takeshi Miyanaga

发明人： Keisuke Shinagawa ,  Shuzo Fujimura ,  Yuuji Matoba ,  Yoshimasa Nakano ,  Tatsuya Takeuchi ,  Takeshi Miyanaga

IPC分类号： C23C16/448 ,  H01L21/00 ,  A61M33/06 ,  B05C11/00 ,  F22B29/06

CPC分类号： H01L21/67017 ,  C23C16/4485

摘要： A method for controlling an apparatus for supplying steam to an ashing process. The apparatus includes a closed water-containing vessel formed from a material having good heat conductive characteristics for evaporating water to provide steam to a vacuum chamber housing an ongoing ashing process. In accordance with the procedure, steam evaporated in a closed steam supply tank is introduced into a vacuum chamber via a pressure reducing mass-flow controller. The temperature of the water in the supply tank, the temperature of the steam in the pipes leading from the supply tank to the mass-flow controller, the temperature of the steam in the pipes from the mass-flow controller to the vacuum chamber and the temperature of the steam in the mass-flow controller itself are all independently controlled such that the temperature in the water tank is equal to or less than the temperature in the pipes leading to and from the mass-flow controller and the temperature in the pipes is less than or equal to the temperature in the mass-flow controller.

摘要翻译： 一种用于控制用于向灰化过程供应蒸汽的装置的方法。 该装置包括由具有良好导热特性的材料形成的封闭的含水容器，用于蒸发水以向容纳正在进行的灰化过程的真空室提供蒸汽。 按照该程序，在封闭的蒸汽供应罐中蒸发的蒸汽通过减压质量流量控制器引入真空室。 供水箱内水的温度，从供水箱通向质量流量控制器的管道中的蒸汽温度，从质量流量控制器到真空室的管道中的蒸汽温度以及 质量流量控制器本身的蒸汽温度都是独立控制的，使得水箱中的温度等于或小于通向质量流量控制器的管道中的温度，并且管道中的温度为 小于或等于质量流量控制器中的温度。

公开(公告)号：US5459142A

公开(公告)日：1995-10-17

申请号：US110797

申请日：1993-08-23

申请人： Hitoshi Tone ,  Seiji Sato ,  Katsumi Tamura ,  Hideaki Sato ,  Toshiki Miyazaki ,  Yoshimasa Nakano

发明人： Hitoshi Tone ,  Seiji Sato ,  Katsumi Tamura ,  Hideaki Sato ,  Toshiki Miyazaki ,  Yoshimasa Nakano

IPC分类号： A61K31/495 ,  A61P1/16 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/00 ,  C07D241/24 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D241/24 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： Novel pyrazine derivatives represented by the formula (1) and salts thereof which possess inhibitory effect against superoxide radicals (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation, and also possess anti-albuminuria activity in Masugi nephritis. ##STR1## The pyrazine derivatives (1) and salts thereof are useful agents for preventing and treating of various diseases caused by the superoxide radicals, for example, diseases of autoimmune such as rheumatoid arthritis, arteriosclerosis, ischemic heart disease, transient cerebral ischematic attack, hepatic insufficiency, renal insufficiency and the like, as well as they are useful agents for preventing and treating the nephritis in various clinical fields.

摘要翻译： 由式（1）表示的新型吡嗪衍生物及其盐，其通过刺激从豚鼠的巨噬细胞释放出具有对超氧自由基（O 2 - ）的抑制作用，并且还具有马苏吉性肾炎中的抗白蛋白尿活性。 （1）吡嗪衍生物（1）及其盐是预防和治疗由超氧化物自由基引起的各种疾病的有用试剂，例如自身免疫性疾病如类风湿性关节炎，动脉硬化，缺血性心脏病，暂时性大脑 缺血发作，肝功能不全，肾功能不全等，也是各种临床领域预防和治疗肾炎的有用药物。

公开(公告)号：US4371524A

公开(公告)日：1983-02-01

申请号：US241294

申请日：1981-03-06

申请人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

发明人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

IPC分类号： C07H15/256 ,  A61K31/70

CPC分类号： C07H15/256

摘要： A pharmaceutical composition having an anticomplementary activity comprising a therapeutically effective amount of at least one soyasapogenol B compound represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group represented by the formula: ##STR2## wherein R.sup.2 represents a hydrogen atom or a hydroxymethyl group, R.sup.3 represents a hydrogen atom or a rhamnopyranosyl group, and R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.

摘要翻译： 一种具有抗补体活性的药物组合物，其包含治疗有效量的由通式（I）表示的至少一种大豆皂草酚B化合物：其中R 1表示氢原子或由下式表示的基团：其中R2表示氢原子或羟甲基，R3表示氢原子或鼠李糖吡喃糖基，R4表示氢原子或碳原子数1〜6的烷基或其药学上可接受的盐和药学上可接受的载体。

公开(公告)号：US6115538A

公开(公告)日：2000-09-05

申请号：US462561

申请日：1995-06-05

申请人： Keisuke Shinagawa ,  Shuzo Fujimura ,  Yuuji Matoba ,  Yoshimasa Nakano ,  Tatsuya Takeuchi ,  Takeshi Miyanaga

发明人： Keisuke Shinagawa ,  Shuzo Fujimura ,  Yuuji Matoba ,  Yoshimasa Nakano ,  Tatsuya Takeuchi ,  Takeshi Miyanaga

IPC分类号： C23C16/448 ,  H01L21/00 ,  A61H33/06 ,  A61H33/12

CPC分类号： H01L21/67017 ,  C23C16/4485 ,  H01L21/6715

摘要： A steam supplying apparatus for supplying steam to an ashing process. The apparatus includes a closed water-containing vessel formed from a material having good heat conductive characteristics for evaporating water to provide steam to a vacuum chamber housing an on going ashing process. The closed vessel has a maximum horizontal cross sectional water evaporation area M and a minimum horizontal cross sectional water evaporation area S. The vessel is configured so that M/S

摘要翻译： 一种用于向灰化过程供应蒸汽的蒸汽供应装置。 该装置包括由具有良好导热特性的材料形成的封闭含水容器，用于蒸发水以将蒸汽提供到容纳进行灰化过程的真空室。 密闭容器具有最大水平横截面水蒸发面积M和最小水平横截面水蒸发面积S.容器被配置为使得M / S <8，并且密封容器具有浸没的内表面，其被涂覆有 树脂。 封闭的含水容器在其中的水表面上方的位置处设置有与其连接的蒸汽出口。 该装置还包括用于封闭含水容器的温度控制液槽，并且容器至少部分地浸没在液槽中。

公开(公告)号：US5174153A

公开(公告)日：1992-12-29

申请号：US858680

申请日：1992-03-27

申请人： Yoshimasa Nakano

发明人： Yoshimasa Nakano

IPC分类号： G01F23/22 ,  G01F23/24

CPC分类号： G01F23/22 ,  G01F23/246

摘要： The detecting device according to the present invention is provided with a case, a first and second detecting pads which juts from the case and which can be closely attached to the outer wall of the receptacle, supports which are connected to the first and second detecting pads in a thermal-conducting manner, a first thermistor and heater embedded in the support of the first detecting pad, a second thermistor embedded in the support of the second detecting pad, and a detector circuit which measures the quantity of heat transmitted from the first detecting pad into the receptacle in accordance with a change in the output of the first thermistor when the first detecting pad and the support thereof are heated by the heater to a preset temperature which is above the reference temperature of the second detecting pad and the support thereof, thus detecting the level of a liquid in the receptacle from the measured quantity of heat transmitted.

摘要翻译： 根据本发明的检测装置设置有壳体，第一和第二检测垫，其从壳体突出并且可以紧密地附接到容器的外壁，支撑件连接到第一和第二检测垫 以导热方式，嵌入在第一检测焊盘的支撑体中的第一热敏电阻和加热器，嵌入在第二检测焊盘的支撑体中的第二热敏电阻，以及检测电路，其测量从第一检测焊盘传递的热量 当第一检测焊盘及其支撑体被加热器加热到高于第二检测焊盘及其支撑件的基准温度的预设温度时，根据第一热敏电阻器的输出的变化，焊盘插入插座中， 从而从所测量的热量传输来检测容器中的液体的水平。

公开(公告)号：US4831053A

公开(公告)日：1989-05-16

申请号：US81581

申请日：1987-08-03

申请人： Masanao Shinohara ,  Hirotsugu Kaise ,  Yoshimasa Nakano ,  Taketoshi Izawa ,  Yasuo Oshiro ,  Wasei Miyazaki

发明人： Masanao Shinohara ,  Hirotsugu Kaise ,  Yoshimasa Nakano ,  Taketoshi Izawa ,  Yasuo Oshiro ,  Wasei Miyazaki

IPC分类号： C07D307/94 ,  A61K31/34 ,  A61K31/365 ,  A61P1/16 ,  C07D493/10

CPC分类号： A61K31/34 ,  Y10S514/892

摘要： A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or (II) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.

摘要翻译： 公开了一种用于肝炎的预防或治疗组合物，其包含预防或治疗有效量的由式（I）或（II）表示的倍半萜烯化合物或其药学上可接受的盐作为 活性成分和药学上可接受的载体。

公开(公告)号：US5238938A

公开(公告)日：1993-08-24

申请号：US857726

申请日：1992-03-26

申请人： Hitoshi Tone ,  Seiji Sato ,  Hideaki Sato ,  Katsumi Tamura ,  Shigeharu Tamada ,  Kazumi Kondo ,  Tomoyuki Kawaguchi ,  Yoshimasa Nakano ,  Yasuyuki Kita ,  Shuji Akai ,  Hiromichi Fujioka ,  Yasumitsu Tamura ,  Katsuhide Matoba ,  Youichi Taniguchi ,  Shinji Nishitani ,  Satoshi Hayakawa ,  Toshinori Kaneyasu ,  Yoshihiko Ito ,  Masahiro Murakami

发明人： Hitoshi Tone ,  Seiji Sato ,  Hideaki Sato ,  Katsumi Tamura ,  Shigeharu Tamada ,  Kazumi Kondo ,  Tomoyuki Kawaguchi ,  Yoshimasa Nakano ,  Yasuyuki Kita ,  Shuji Akai ,  Hiromichi Fujioka ,  Yasumitsu Tamura ,  Katsuhide Matoba ,  Youichi Taniguchi ,  Shinji Nishitani ,  Satoshi Hayakawa ,  Toshinori Kaneyasu ,  Yoshihiko Ito ,  Masahiro Murakami

IPC分类号： C07D403/04 ,  C07D403/06

CPC分类号： C07D403/04 ,  C07D403/06

摘要： The novel indole derivatives and salts thereof represented by the general formula (1) ##STR1## possess, for example, an inhibitory effect against superoxide (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation and an anti-albuminuria activity against Masugi nephritis, and are useful in various clinical fields as an agent for preventing and treating diseases and cases associated with the above superoxide radical, for example, autoimmune diseases (e.g. rheumatism), arteriosclerosis, ischemic disease, ischemic encephalopathia, hepatic insufficiency and renal insufficiency, and also as an agent for preventing and treating nephritis.

摘要翻译： 由通式（1）表示的新的吲哚衍生物及其盐具有例如通过刺激和抗白蛋白尿对豚鼠巨噬细胞释放的对超氧化物（O 2 - ）的抑制作用 针对Masugi肾炎的活性，并且在各种临床领域中用作预防和治疗与上述超氧化物基团相关的疾病和病例的药剂，例如自身免疫性疾病（例如风湿病），动脉硬化，缺血性疾病，缺血性脑病，肝功能不全和 肾功能不全，还可用作预防和治疗肾炎的药剂。

公开(公告)号：US07331716B2

公开(公告)日：2008-02-19

申请号：US10492136

申请日：2003-03-11

申请人： Yoshimasa Nakano ,  Tadaaki Kurosu ,  Shinichi Inoue ,  Etsuko Hattori

发明人： Yoshimasa Nakano ,  Tadaaki Kurosu ,  Shinichi Inoue ,  Etsuko Hattori

IPC分类号： B65D33/00 ,  B65D65/26

CPC分类号： B65D75/48 ,  B65D75/52 ,  B65D75/5816

摘要： There are provided a flexible container capable of realizing facilitation of opening and uniformization of the shape of an opening that is obtained by opening, a method of forming the flexible container, a seal-breaking guide of the flexible container, a method of enclosing a liquid in the flexible container, and the liquid enclosed in the flexible container. The invention relates to the flexible container which is openable by tearing, the method of forming the flexible container, the seal-breaking guide of the flexible container, the method of enclosing a liquid in the flexible container, and the liquid enclosed in the flexible container, and has seal parts (a center seal part 4, a top seal part 6, a bottom seal part 8) for sealing a holding part (2) formed of a flexible material (3), cuts (12, 14) formed in the seal parts and a seal-breaking guide of the flexible container (16) formed in the seal parts for giving guidance for a direction of tearing of the holding part which is openable by tearing, thereby realizing facilitation of opening and uniformization of the shape of an opening that is obtained by opening.

摘要翻译： 提供了一种灵活的容器，其能够实现打开时获得的开口形状的开放均匀化，柔性容器的形成方法，柔性容器的密封破坏导向器，封闭液体的方法 在柔性容器中，以及封闭在柔性容器中的液体。 本发明涉及通过撕裂可开启的柔性容器，形成柔性容器的方法，柔性容器的密封破坏导向器，将柔性容器中的液体封闭的方法以及封装在柔性容器中的液体 并且具有用于密封由柔性材料（3）形成的保持部（2）的密封部（中心密封部4，顶部密封部6，底部密封部8），形成在上述密封部 密封部件和形成在密封部分中的柔性容器（16）的密封部件和密封件引导件，用于引导可撕裂的保持部件的撕裂方向，从而实现打开和均匀化的形状 开放是通过开放获得的。

公开(公告)号：US4217345A

公开(公告)日：1980-08-12

申请号：US25518

申请日：1979-03-30

申请人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

发明人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

IPC分类号： C07J63/00 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K36/48 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/00 ,  C07H15/256 ,  C12P7/00 ,  C12P19/56 ,  C07H15/20 ,  C07H15/24

CPC分类号： C12R1/645 ,  C07H15/256 ,  C12P19/56 ,  Y10S514/885

摘要： 3-0-(.beta.-D-Glucuronopyranosyl)-soyasapogenol B represented by the formula (I): ##STR1## and salts thereof and process for preparing the same are disclosed. The compound represented by the formula (I) and salts thereof have anticomplementary activity and are useful as therapeutic agents for autoimmune diseases, collagen diseases, and rheumatic diseases.

摘要翻译： 公开了由式（I）表示的3-0-（β-D-葡萄糖醛酸吡喃糖基） - 邻磺基苯甲酸：其中，其盐及其制备方法。 由式（I）表示的化合物及其盐具有抗补体活性，可用作自身免疫性疾病，胶原性疾病和风湿性疾病的治疗剂。

公开(公告)号：US5607934A

公开(公告)日：1997-03-04

申请号：US397043

申请日：1995-03-10

申请人： Hitoshi Tone ,  Masatoshi Morisue ,  Katsumi Tamura ,  Toshiki Miyazaki ,  Yoshimasa Nakano

发明人： Hitoshi Tone ,  Masatoshi Morisue ,  Katsumi Tamura ,  Toshiki Miyazaki ,  Yoshimasa Nakano

IPC分类号： A61K31/505 ,  A61P3/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07D209/20 ,  C07D241/08 ,  C07D403/06 ,  C07D405/12 ,  C07D417/12 ,  A61K31/495 ,  C07D241/02 ,  C07D241/04 ,  C07D403/02

CPC分类号： C07D403/06 ,  C07D241/08 ,  C07D405/12 ,  C07D417/12

摘要： Piperazine compounds and salts thereof having inhibitory effect against superoxide radicals (O.sub.2.sup.-). The piperazine compounds have the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group;R.sup.2 is a phenyl-lower alkyl group which may have 1 to 3 substituents, on the phenyl ring, selected from the group consisting of a hydroxyl group, a phenyl-lower alkoxy group, a lower alkyl group, a lower alkoxy group and a halogen atom;R.sup.3 is a hydrogen atom, a lower alkyl group or a phenyl-lower alkyl group; andR.sup.4 is a hydroxyl group, a phenyl-lower alkoxy group or a tetrahydropyranyloxy group.

摘要翻译： PCT No.PCT / JP94 / 01071 Sec。 371 1995年3月10日 102（e）1995年3月10日PCT PCT 1994年7月1日PCT公布。 公开号WO95 / 02593 日期1995年1月26日具有对超氧化物基（O 2 - ）具有抑制作用的哌嗪化合物及其盐。 哌嗪化合物具有以下通式：其中R 1是低级烷基; R2是在苯环上可以具有1至3个取代基的苯基 - 低级烷基，其选自羟基，苯基 - 低级烷氧基，低级烷基，低级烷氧基和卤素 原子; R3是氢原子，低级烷基或苯基 - 低级烷基; R4是羟基，苯基 - 低级烷氧基或四氢吡喃氧基。