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公开(公告)号：US20230013602A1
公开(公告)日：2023-01-19
申请号：US17349888
申请日：2021-06-16
发明人： Jean-Baptiste BLANC , Nawaz KHAN , Christian KRAMER , Christian LERNER , Philippe PFLIEGER , Theodor STOLL , Song YANG
IPC分类号： C07D487/04 , A61P31/04 , B01J31/12
摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.-
公开(公告)号：US20230141403A1
公开(公告)日：2023-05-11
申请号：US18076383
申请日：2022-12-06
发明人： Zhanling CHENG , Xingchun HAN , Christian KRAMER , Holger KUEHNE , Christian LERNER , Mingming LI , Matthias NETTEKOVEN , Theodor STOLL , Min WANG , Song YANG
IPC分类号： C07D487/04 , A61P31/04
CPC分类号： C07D487/04 , A61P31/04
摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein:
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.-
公开(公告)号：US20230133845A1
公开(公告)日：2023-05-04
申请号：US17865192
申请日：2022-07-14
发明人： Mathis BRAENDLIN , Sandra Marie Joseph GRALL-ULSEMER , Xingchun HAN , Christian LERNER , Mingming LI , Yongqiang LIU , Sébastien SCHMITT , Jianhua WANG , Yongguang WANG , Min WANG , Song YANG , Chengang ZHOU
IPC分类号： C07D401/14 , C07D403/10 , C07D403/14 , A61P31/04
摘要： The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
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公开(公告)号：US20230012368A1
公开(公告)日：2023-01-12
申请号：US17349832
申请日：2021-06-16
发明人： Jean-Baptiste BLANC , Zhanling CHENG , Xingchun HAN , Nawaz KHAN , Christian KRAMER , Holger KUEHNE , Christian LERNER , Matthias NETTEKOVEN , Philippe PFLIEGER , Bernd PUELLMANN , Sebastien SCHMITT , Theodor STOLL , Jianhua WANG , Yongguang WANG , Song YANG
IPC分类号： C07D487/04 , C07F9/6561 , C07D519/00 , C07H9/06 , A61P31/04
摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.-
公开(公告)号：US20230141600A1
公开(公告)日：2023-05-11
申请号：US18076274
申请日：2022-12-06
发明人： Zhanling CHENG , Christian KRAMER , Christian LERNER , Yongqiang LIU , Matthias NETTEKOVEN , Philippe PFLIEGER , Sébastien SCHMITT , Theodor STOLL , Jianhua WANG , Yongguang WANG , Song YANG , Chengang ZHOU
IPC分类号： C07D487/04 , C07D519/00 , A61P31/04 , A61K9/20 , A61K9/48 , A61K9/08 , A61K47/12 , A61K47/40
CPC分类号： C07D487/04 , C07D519/00 , A61P31/04 , A61K9/2054 , A61K9/2059 , A61K9/2009 , A61K9/4866 , A61K9/4858 , A61K9/485 , A61K9/08 , A61K47/12 , A61K47/40
摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein:
or pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.-
公开(公告)号：US20230017532A1
公开(公告)日：2023-01-19
申请号：US17349862
申请日：2021-06-16
发明人： Zhanling CHENG , Nawaz KHAN , Christian KRAMER , Christian LERNER , Matthias NETTEKOVEN , Philippe PFLIEGER , Bernd PUELLMANN , Sebastien SCHMITT , Theodor STOLL , Jianhua WANG , Song YANG
IPC分类号： C07D487/04 , C07D519/00
摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.-
公开(公告)号：US20230011869A1
公开(公告)日：2023-01-12
申请号：US17349800
申请日：2021-06-16
发明人： Zhanling CHENG , Nawaz KHAN , Christian KRAMER , Christian LERNER , Philippe PFLIEGER , Theodor STOLL , Jianhua WANG , Min WANG , Yongguang WANG , Song YANG
IPC分类号： C07D487/04 , C07D519/00
摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
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公开(公告)号：US20230022724A1
公开(公告)日：2023-01-26
申请号：US17349760
申请日：2021-06-16
发明人： Zhanling CHENG , Nawaz KHAN , Christian KRAMER , Christian LERNER , Philippe PFLIEGER , Theodor STOLL , Jianhua WANG , Yongguang WANG , Song YANG
IPC分类号： C07D487/04 , A61P31/04
摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.-
公开(公告)号：US20220396565A1
公开(公告)日：2022-12-15
申请号：US17869755
申请日：2022-07-20
发明人： Zhanling CHENG , Xingchun HAN , Christian KRAMER , Christian LERNER , Yongqiang LIU , Matthias NETTEKOVEN , Philippe PFLIEGER , Bernd PUELLMANN , Jianhua WANG , Lisha WANG , Min WANG , Yongguang WANG , Song YANG , Chengang ZHOU
IPC分类号： C07D403/12 , C07D233/90 , C07D403/14 , C07D487/10 , C07D401/14
摘要： Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
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